DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wry and dner

DIOPT Version :9

Sequence 1:	NP_995611.2	Gene:	wry / 33361	FlyBaseID:	FBgn0051665	Length:	1157	Species:	Drosophila melanogaster
Sequence 2:	NP_001269415.1	Gene:	dner / 100332110	ZFINID:	ZDB-GENE-130502-1	Length:	744	Species:	Danio rerio

Alignment Length:	630	Identity:	183/630 - (29%)
Similarity:	255/630 - (40%)	Gaps:	146/630 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   476 LLKALTPPKSVDKSTASPSSTTSTSTSTTTTMATLLATARTRPSAANPTKTASKPIARPRILSRL 540
            |.::|.|..:...:.|:|::||.....||....|          .|.||....:|.|..|:|..|
Zfish   142 LAESLVPEHATPATPATPATTTQVLQPTTVLTTT----------QAPPTLEPWQPRAGQRVLEIL 196

  Fly   541 ---QEKINSLECEIPNVPQDSHLWRGNETHELLLPIVTTEHCKPDEHCVPNVLTWRGE-AEIQSG 601
               |:..|..||                                       |.|..|| |.:.|.
Zfish   197 WDDQQITNEAEC---------------------------------------VSTAGGESAGMMSI 222

  Fly   602 DILIVEINDAMLNPSHEPNNTSSAVHATQVYQVTRSGHEHCDVTEGVLLDITPLVVDGRKLVTLY 666
            .:.:.|.....|    ..|.:.|||    :::|..||:|.|.|.:|.::    ......:.:.|.
Zfish   223 SLELAEETAVKL----VGNVSGSAV----LWRVGASGYEQCSVADGTIM----WFQQSSEGLVLP 275

  Fly   667 DKDLTEGVN---LLIVVSELWGAQCVRLKVTTKTDNCGE------NADCSGKGVCYSNSGMEEYE 722
            |:.|..|.|   .|:|.|.......:||.:..||:||.|      :..|||||.|.:.|.::.:.
Zfish   276 DQSLPLGHNYFITLLVGSPSGPEVTLRLHLLVKTNNCMEPGSAFSDPQCSGKGKCVTQSSVDTFY 340

  Fly   723 CQCCSGFAGPHCEEIDACNPSPCTNNGICVDLSQGHEGNSYQCLCPYGYAGKNCQ---------- 777
            |:|..|::|..|||.|||:..||.|||.|.||.|..||.:|.|.|..|:.|:.||
Zfish   341 CRCDDGYSGIFCEEFDACHLKPCENNGSCADLRQRDEGQNYTCTCQTGFEGERCQSLVDHCVSGP 405

  Fly   778 ---------------------YES-------DPCNPAECMNGGSC--VGNSTHFRCDCAPGFTGP 812
                                 |:.       |||....|.|..||  .|....|.|.|..|||||
Zfish   406 CRNGATCSSSLEGPHCYCAEGYQGIMCEQKIDPCASGPCHNNASCSPQGAGLGFSCTCPAGFTGP 470

  Fly   813 LCQHSLNECESSPCVHGICVDQEDGFRCFCQPGFAGELCNFEYNECESNPCQNGGECIDHIGSYE 877
            .|...::.|..:||.||||......:||.|.||:.|..|..|||||.|.||||...|.|.|.:||
Zfish   471 TCAQLVDFCALNPCAHGICRSIGTSYRCLCVPGYHGLYCEEEYNECLSAPCQNYATCRDLINAYE 535

  Fly   878 CRCTKGFSGNRCQIKVDFCANKPCPEGHRCIDHGNDFSCECPGGRNGPDCNQMPRTYFQQCNVNP 942
            |.|...|:|..|:|..|.|....|..|..|...|.:.||.||.|..|.:|    .....:|..||
Zfish   536 CICASQFTGKHCEIYKDPCLKLRCQNGGHCESGGRNASCVCPPGYMGENC----EVDVNECESNP 596

  Fly   943 CTHGGTCWSSGDSFYCACRPGYTGTMCEDEF---VVETVVSSSEFIVDDANARNFNDKTFGSSVV 1004
            |.|||||....:.:.|.|.||:.|..||...   :.:.|.|.:.
Zfish   597 CHHGGTCIDQSNGYTCHCPPGWVGGSCEIHLQWKMAQPVDSLTN--------------------- 640

  Fly  1005 LKSPIELHNAYFAAGVLAAAIFIVAVVVTICHCKVNQTYRKFSTR 1049
                :..|:.|...|.|..|..::.:::.:..|::::...:.|:|
Zfish   641 ----MPRHSLYIIIGALCVAFVLMLIILIVGICRISRIEYQGSSR 681

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wry	NP_995611.2	EGF_CA	737..777	CDD:238011	19/39 (49%)
		EGF	783..812	CDD:278437	12/30 (40%)
		EGF_CA	819..851	CDD:238011	13/31 (42%)
		EGF_CA	856..890	CDD:238011	17/33 (52%)
		EGF_CA	893..927	CDD:238011	12/33 (36%)
		EGF_CA	<941..970	CDD:238011	13/28 (46%)
dner	NP_001269415.1	PHA03099	<99..>126	CDD:165381
		EGF_CA	398..433	CDD:238011	1/34 (3%)
		EGF_CA	436..472	CDD:238011	16/35 (46%)
		EGF_CA	476..510	CDD:238011	13/33 (39%)
		EGF_CA	514..548	CDD:238011	17/33 (52%)
		EGF_CA	<559..586	CDD:238011	11/30 (37%)
		EGF_CA	588..624	CDD:238011	14/35 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D199127at33208
OrthoFinder	1	1.000	-	-		FOG0008370
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6356
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920