DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment c-cup and PGRMC2

DIOPT Version :9

Sequence 1:	NP_608623.2	Gene:	c-cup / 33360	FlyBaseID:	FBgn0031367	Length:	201	Species:	Drosophila melanogaster
Sequence 2:	NP_006311.3	Gene:	PGRMC2 / 10424	HGNCID:	16089	Length:	223	Species:	Homo sapiens

Alignment Length:	127	Identity:	31/127 - (24%)
Similarity:	56/127 - (44%)	Gaps:	21/127 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 TLEELTAFDGS-SPSLPIYTALNGLIYDLSPGREKFSSHGPYSLLAGCNANKVLNIAC------- 143
            :||:|..:||| :|.  |..|:||.::|::.|.:.:...|||.:.||.:|::.|...|
Human   104 SLEQLRQYDGSRNPR--ILLAVNGKVFDVTKGSKFYGPAGPYGIFAGRDASRGLATFCLDKDALR 166

  Fly   144 ------SSMGVCAANVISRWEQSLRAEFKVVGYLVDADIDIISGSPVKHTNSAIGEQMEKSD 199
                  |.:.......:..||...:.::..||.|:..     ...|.::|:....:...|.|
Human   167 DEYDDLSDLNAVQMESVREWEMQFKEKYDYVGRLLKP-----GEEPSEYTDEEDTKDHNKQD 223

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
c-cup	NP_608623.2	Cyt-b5	87..>115	CDD:295147	12/28 (43%)
PGRMC2	NP_006311.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..33
PGRMC2	NP_006311.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	202..223		3/25 (12%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910