DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17712 and gfod1

DIOPT Version :9

Sequence 1:	NP_608619.1	Gene:	CG17712 / 33356	FlyBaseID:	FBgn0027597	Length:	384	Species:	Drosophila melanogaster
Sequence 2:	XP_009295943.1	Gene:	gfod1 / 556899	ZFINID:	ZDB-GENE-091118-89	Length:	391	Species:	Danio rerio

Alignment Length:	398	Identity:	181/398 - (45%)
Similarity:	256/398 - (64%)	Gaps:	26/398 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLPGVGVFGTGEIANVLVPLLREKGFEVRAIWGRTLKEAKETATTQNVQFHTNVIDDVLLRKDVD 65
            ||||||||||...|.|::|||:.:||.|:|:||||.:||:|.|...||.|:||.||||||..|||
Zfish     1 MLPGVGVFGTSLTARVIIPLLKGEGFSVKALWGRTQEEAEELARDMNVPFYTNRIDDVLLHPDVD 65

  Fly    66 LVFIVCQPFLHAEISVKALGIGKHVVCDKPAGLHQQDALKMVRASQYYPTLISLVNHPLRFLPAF 130
            ||.|...|.|..:|:||.|||||:|:||:.|  ...||.:|:.|:||||.|:|::.:.|||||||
Zfish    66 LVCINLPPPLTRQIAVKTLGIGKNVICDRTA--TPLDAFRMMSAAQYYPKLLSIMGNVLRFLPAF 128

  Fly   131 THMRRCLQEELIGSIGDVVLMDVRVQMGTLFPEKYNWMCDAQMGGGALNLVGS-VVDLVTFLLQQ 194
            ..|:..|:|   |.||::::.:.:|..|:|..:||||.||..||||.|:.||| ::||:|||..:
Zfish   129 VRMKELLEE---GYIGELMVCEAQVHSGSLLGKKYNWSCDDLMGGGGLHSVGSYIIDLLTFLTGR 190

  Fly   195 QAIRVHGVLRSYTKTTPAINGIRQITAPDFCNFQMELASGTLVTVALHSHTVPAKAFSQEVLIYG 259
            :|.:|||.|:::.|.|..|.||||||:.|||.|||.|..|...||.| :..||.: |.|||::.|
Zfish   191 RAAKVHGFLKTFVKQTDHIRGIRQITSDDFCTFQMVLEGGACCTVTL-NFNVPGE-FRQEVVVVG 253

  Fly   260 SKGHLVVRGGDLFVLK-EGQPKEEAVYVDVQDLHFATNNSL-------LPRPYIKGLCKMVGALK 316
            :.|.|.|.|.||:..| :|:..:|.:   ::|.....|.||       :|.||:.|...||.|::
Zfish   254 TAGRLKVCGTDLYGQKNDGECGQELL---LKDKTAIGNASLPDKAFRDIPSPYLTGTICMVQAVR 315

  Fly   317 EAFGSKES--SWVKAPVSTAATFEDGLYVQAVVEAIRKSNETRQWQRVQLSTDSP-----LNHDQ 374
            :||..::.  :|...|::.||||||.||...||:.|:|||:..:||.:::.|:.|     ....:
Zfish   316 QAFQDQDDRRTWDGRPLTMAATFEDCLYALCVVDTIKKSNQCGEWQNIEVMTEEPEVSPAYLISE 380

  Fly   375 IIRYARMS 382
            .:|.:|||
Zfish   381 AMRRSRMS 388

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17712	NP_608619.1	MviM	5..364	CDD:223745	171/369 (46%)
gfod1	XP_009295943.1	MviM	5..>260	CDD:223745	133/261 (51%)
		GFO_IDH_MocA	5..117	CDD:279716	63/113 (56%)
		GFO_IDH_MocA_C	132..>195	CDD:304482	28/65 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590289
Domainoid	1	1.000	189	1.000	Domainoid score	I3226
eggNOG	1	0.900	-	-		E1_COG0673
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H49581
Inparanoid	1	1.050	314	1.000	Inparanoid score	I2550
OMA	1	1.010	-	-		QHG48581
OrthoDB	1	1.010	-	-		D356632at33208
OrthoFinder	1	1.000	-	-		FOG0001912
OrthoInspector	1	1.000	-	-		otm24384
orthoMCL	1	0.900	-	-		OOG6_104973
Panther	1	1.100	-	-	O	PTHR43818
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1924
SonicParanoid	1	1.000	-	-		X2601
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800