DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17646 and ABCG2

DIOPT Version :9

Sequence 1:	NP_608618.1	Gene:	CG17646 / 33354	FlyBaseID:	FBgn0264494	Length:	766	Species:	Drosophila melanogaster
Sequence 2:	NP_001335914.1	Gene:	ABCG2 / 9429	HGNCID:	74	Length:	655	Species:	Homo sapiens

Alignment Length:	723	Identity:	192/723 - (26%)
Similarity:	323/723 - (44%)	Gaps:	140/723 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 TNDLNGFQSPNYHQAVAHANFDHCDPVDIQFADVRYTVK-KFSF-PERKFVTKEILHGLNGSFRS 140
            :|||..|                .:...:.|.::.|.|| |..| |.||.|.||||..:||..:.
Human    25 SNDLKAF----------------TEGAVLSFHNICYRVKLKSGFLPCRKPVEKEILSNINGIMKP 73

  Fly   141 GELTAIMGPSGAGKSTLLNVMSGFCS-TGVSGDIRVNRKPMAPSSERFRQMLCYIHQDDLLRPQL 204
            | |.||:||:|.|||:||:|::.... :|:|||:.:|.   ||....|:....|:.|||::...|
Human    74 G-LNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLING---APRPANFKCNSGYVVQDDVVMGTL 134

  Fly   205 LVGEIMLLAAHLKLGFKVTKAYKMDLIKHILSLLGLDHRYNVPTGK-----LSGGQKKRLAIALE 264
            .|.|.:..:|.|:|...:|...|.:.|..::..||||...:...|.     :|||::||.:|.:|
Human   135 TVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGTQFIRGVSGGERKRTSIGME 199

  Fly   265 LISNPPVLYLDEPTTGLDSSSCSSCVALLKKLASQGHTIVCTIHQPSALIFEMFDKLYTVVDGHC 329
            ||::|.:|:|||||||||||:.::.:.|||:::.||.||:.:||||...||::||.|..:..|..
Human   200 LITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSIFKLFDSLTLLASGRL 264

  Fly   330 MYQGPVRELVPFLADQQLVCPSYHNPADYLLEVAVGEHQRDLNELIHAANKKYYEDVDRHRYMSS 394
            |:.||.:|.:.:.......|.:|:||||:.|::..|:      ....|.|::  ||.
Human   265 MFHGPAQEALGYFESAGYHCEAYNNPADFFLDIINGD------STAVALNRE--EDF-------- 313

  Fly   395 DDMARLVESIKENMGGKAVVKTSEALAAFAAAQFSSFDYVKPSPQELALEEIKALSGGPESADPD 459
                :..|.|:.:...|.::   |.||..         ||..|..:....|:..|||
Human   314 ----KATEIIEPSKQDKPLI---EKLAEI---------YVNSSFYKETKAELHQLSG-------- 354

  Fly   460 LLEKNLRPQPQPLAKAGELARPPNAIRSASFLMQYVLLMQRILICAKRNYFLLL-------ARIF 517
                            ||..:.....:..|:...:...::.:   :||::..||       |:|.
Human   355 ----------------GEKKKKITVFKEISYTTSFCHQLRWV---SKRSFKNLLGNPQASIAQII 400

  Fly   518 SHIFIGVVFGYLYMNVGNNAQSVLGNYVYLYGSTLLLVYTGKMAVVLTFPLEIDMLTREHFNRWY 582
            ..:.:|:|.|.:|..:.|::..:......|:..|....::...||.| |.:|..:...|:.:.:|
Human   401 VTVVLGLVIGAIYFGLKNDSTGIQNRAGVLFFLTTNQCFSSVSAVEL-FVVEKKLFIHEYISGYY 464

  Fly   583 KLGPYFL-SLISFEIPFQSLCTAMYIIISVHLTG-NDATDSFRIYYFMLLGIMASLSAQAWGFFV 645
            ::..||| .|:|..:|.:.|.:.::..|...:.| ....|:|.:..|.|:.:..|.|:.|.....
Human   465 RVSSYFLGKLLSDLLPMRMLPSIIFTCIVYFMLGLKPKADAFFVMMFTLMMVAYSASSMALAIAA 529

  Fly   646 GATLPTKLAVFLGPILAVMFSVFGFCTRYIDITPLFRWMWHLSYF---RAGF----HG------- 696
            |.:: ..:|..|..|..|...:|.  ...:::|.:..|:..|.||   |.||    |.
Human   530 GQSV-VSVATLLMTICFVFMMIFS--GLLVNLTTIASWLSWLQYFSIPRYGFTALQHNEFLGQNF 591

  Fly   697 --ALNAIYGMDRPFLECPETAMYCHFRSPKVFLKYMMISDVHMSD-----------CLILMGIVI 748
              .|||.......:..|...             :|::...:.:|.           |:|::.:.|
Human   592 CPGLNATGNNPCNYATCTGE-------------EYLVKQGIDLSPWGLWKNHVALACMIVIFLTI 643

  Fly   749 GVMHVLTL 756
            ..:.:|.|
Human   644 AYLKLLFL 651

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17646	NP_608618.1	ABCG_EPDR	103..333	CDD:213180	95/237 (40%)
		3a01204	123..765	CDD:273361	181/676 (27%)
		ABC2_membrane	497..698	CDD:279410	51/225 (23%)
ABCG2	NP_001335914.1	3a01204	55..649	CDD:273361	179/673 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X52
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.820