DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17646 and Abcg1

DIOPT Version :9

Sequence 1:	NP_608618.1	Gene:	CG17646 / 33354	FlyBaseID:	FBgn0264494	Length:	766	Species:	Drosophila melanogaster
Sequence 2:	NP_445954.2	Gene:	Abcg1 / 85264	RGDID:	620294	Length:	666	Species:	Rattus norvegicus

Alignment Length:	758	Identity:	274/758 - (36%)
Similarity:	403/758 - (53%)	Gaps:	107/758 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 AACCVGGANSDASSSSGVCSLKGHHGDPDSGCLGINCCTTAASSELSIDETSSTSSRGSCELTSK 76
            ||..||.|.:.::.|:.:.       :|.|.|:.::   ...||  ::||..:....|..:   |
  Rat     6 AAFSVGTAMNASNYSAAMT-------EPKSVCVSVD---EVVSS--NVDELETDLLNGHLK---K 55

  Fly    77 VTNDLNGFQSPNYHQAVAHANFDHCDPVDIQFADVRYTVKKFSFPE----RKFVTKEILHGLNGS 137
            |.|        |:.:|...::......|:|:|.|:.|:|     ||    ||...|.:|.|::|.
  Rat    56 VDN--------NFTEAQRFSSLPRRAAVNIEFKDLSYSV-----PEGPWWRKKGYKTLLKGISGK 107

  Fly   138 FRSGELTAIMGPSGAGKSTLLNVMSGFCSTGVSGDIRVNRKPMAPSSERFRQMLCYIHQDDLLRP 202
            |.||||.|||||||||||||:|:::|:..||:.|.:.:|..|.  ....||::.|||.|||:|.|
  Rat   108 FNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGMPR--DLRCFRKVSCYIMQDDMLLP 170

  Fly   203 QLLVGEIMLLAAHLKLGFKVTKAYKMDLIKHILSLLGLDHRYNVPTGKLSGGQKKRLAIALELIS 267
            .|.|.|.|:::|||||..|  ...:.:::|.||:.|||....|..||.|||||:|||||||||::
  Rat   171 HLTVQEAMMVSAHLKLQEK--DEGRREMVKEILTALGLLPCANTRTGSLSGGQRKRLAIALELVN 233

  Fly   268 NPPVLYLDEPTTGLDSSSCSSCVALLKKLASQGHTIVCTIHQPSALIFEMFDKLYTVVDGHCMYQ 332
            ||||::.||||:||||:||...|:|:|.||..|.:||||||||||.:||:||:||.:..|.|:|:
  Rat   234 NPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIVCTIHQPSAKLFELFDQLYVLSQGQCVYR 298

  Fly   333 GPVRELVPFLADQQLVCPSYHNPADYLLEVAVGEHQRDLNELIHAANKKYYEDVDRHRYMSSDDM 397
            |.|..|||:|.|..|.||:||||||:::|||.||:                          .|..
  Rat   299 GKVSNLVPYLRDLGLNCPTYHNPADFVMEVASGEY--------------------------GDQN 337

  Fly   398 ARLVESIKENMGGKAVVKTSEALAAFAAAQFSSFDYVKPSPQELALEEIKALSGGPESADPDLLE 462
            :|||.:::|.|                    ...||    .:||         ||....:|.|..
  Rat   338 SRLVRAVREGM--------------------CDSDY----KREL---------GGDGDVNPFLWH 369

  Fly   463 KNLRPQPQPLAKAGELARPPNAIRSASFLMQYVLLMQRILICAKRNYFLLLARIFSHIFIGVVFG 527
            :........:......        |||.|.|:.:|.:|..:...|:..|...||.|||.||::.|
  Rat   370 RPAEEDSASMEGCHSF--------SASCLTQFCILFKRTFLSIMRDSVLTHLRITSHIGIGLLIG 426

  Fly   528 YLYMNVGNNAQSVLGNYVYLYGSTLLLVYTGKMAVVLTFPLEIDMLTREHFNRWYKLGPYFLSLI 592
            .||:.:||.|:.||.|..:|:.|.|.|::...|..|||||||:.:..|||.|.||.|..|:|:..
  Rat   427 LLYLGIGNEAKKVLSNSGFLFFSMLFLMFAALMPTVLTFPLEMSVFLREHLNYWYSLKAYYLAKT 491

  Fly   593 SFEIPFQSLCTAMYIIISVHLTGNDATDSFRIYYFMLLGIMASLSAQAWGFFVG-ATLPTKLAVF 656
            ..::|||.:....|..|...:| :..:|:.|...|..||.|.||.||:.|..:| |:...::|.|
  Rat   492 MADVPFQIMFPVAYCSIVYWMT-SQPSDAVRFVLFAALGTMTSLVAQSLGLLIGAASTSLQVATF 555

  Fly   657 LGPILAVMFSVF-GFCTRYIDITPLFRWMWHLSYFRAGFHGALNAIYGMDRPFLECPETAMYCHF 720
            :||:.|:...:| ||...:..|....:||.::||.|.||.|.:.:|||:||..|.| :.|..|||
  Rat   556 VGPVTAIPVLLFSGFFVSFDTIPTYLQWMSYISYVRYGFEGVILSIYGLDREDLHC-DIAETCHF 619

  Fly   721 RSPKVFLKYMMISDVHMSDCLILMGIVIGVMHVLTLITLWHKL 763
            :..:..|:.:.:.:..:....|::||....:.::....|.:|:
  Rat   620 QKSEAILRELDVENAKLYLDFIVLGIFFISLRLIAYFVLRYKI 662

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17646	NP_608618.1	ABCG_EPDR	103..333	CDD:213180	121/233 (52%)
		3a01204	123..765	CDD:273361	247/643 (38%)
		ABC2_membrane	497..698	CDD:279410	77/202 (38%)
Abcg1	NP_445954.2	3a01204	60..666	CDD:273361	256/681 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48041
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X52
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	8	7.880