DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17646 and ADP1

DIOPT Version :9

Sequence 1:	NP_608618.1	Gene:	CG17646 / 33354	FlyBaseID:	FBgn0264494	Length:	766	Species:	Drosophila melanogaster
Sequence 2:	NP_009937.2	Gene:	ADP1 / 850369	SGDID:	S000000604	Length:	1049	Species:	Saccharomyces cerevisiae

Alignment Length:	714	Identity:	194/714 - (27%)
Similarity:	330/714 - (46%)	Gaps:	119/714 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 IQFADVRYTVKKFSFPERKFVTKEILHGLNGSFRSGELTAIMGPSGAGKSTLLNVMSGFCSTG-V 169
            :.|.::.|:|...:   ...|.:.:|:.::|..:.|::.||||.|||||:|||::::....|| |
Yeast   384 LSFENITYSVPSIN---SDGVEETVLNEISGIVKPGQILAIMGGSGAGKTTLLDILAMKRKTGHV 445

  Fly   170 SGDIRVNRKPMAPSSERFRQMLCYIHQDDLLRPQLLVGEIMLLAAHLK----LGFKVTKA--YKM 228
            ||.|:||...|...|  |.:::.::.|||.|.|.|.|.|.:|.:|.|:    |.|:..||  ||
Yeast   446 SGSIKVNGISMDRKS--FSKIIGFVDQDDFLLPTLTVFETVLNSALLRLPKALSFEAKKARVYK- 507

  Fly   229 DLIKHILSLLGLDHRY--NVPTGKLSGGQKKRLAIALELISNPPVLYLDEPTTGLDSSSCSSCVA 291
              :...|.::.:..|.  |.....:|||:|:|::||.||:::|.||:|||||:|||:|:.::.:.
Yeast   508 --VLEELRIIDIKDRIIGNEFDRGISGGEKRRVSIACELVTSPLVLFLDEPTSGLDASNANNVIE 570

  Fly   292 LLKKLASQ-GHTIVCTIHQPSALIFEMFDKLYTVVDGHCMYQGPVRELVPFLADQQLVCPSYHNP 355
            .|.:|:|. ..|:|.:||||.:.||.:||||..:..|..:|.|..:::..||.::..:||..:|.
Yeast   571 CLVRLSSDYNRTLVLSIHQPRSNIFYLFDKLVLLSKGEMVYSGNAKKVSEFLRNEGYICPDNYNI 635

  Fly   356 ADYLLEVA-------------------VGEHQRDLNELIH--------AANKKYYEDVDRHRYMS 393
            ||||:::.                   .|....|::..||        ...::.:..:..||
Yeast   636 ADYLIDITFEAGPQGKRRRIRNISDLEAGTDTNDIDNTIHQTTFTSSDGTTQREWAHLAAHR--- 697

  Fly   394 SDDMARLV--ESIKENMGGKAVVKTSEALAAFAAAQFSSFDYVKPSPQELALEEIKALSGGPESA 456
             |::..|:  |...|...|:......:........::....|.....||  :||:  ||.|.|
Yeast   698 -DEIRSLLRDEEDVEGTDGRRGATEIDLNTKLLHDKYKDSVYYAELSQE--IEEV--LSEGDE-- 755

  Fly   457 DPDLLEKNLRPQPQPLAKAGELARPPNAIRSASFLMQYVLLMQRILICAKRNYFLLLARIFSHIF 521
                 |.|:        ..|:|   |...:||.||.|..:|..|......||..|||......|.
Yeast   756 -----ESNV--------LNGDL---PTGQQSAGFLQQLSILNSRSFKNMYRNPKLLLGNYLLTIL 804

  Fly   522 IGVVFGYLYMNVGNNA---QSVLGNYVYLYGSTLLLVYTGKMAVVLTFPLEIDMLTREHFNRWYK 583
            :.:..|.||.||.|:.   |:.:|.:.::......:.:||    :.:|.||..:..:|..|.:|.
Yeast   805 LSLFLGTLYYNVSNDISGFQNRMGLFFFILTYFGFVTFTG----LSSFALERIIFIKERSNNYYS 865

  Fly   584 LGPYFLSLISFE-IPFQSLCTAMYIIISVHLTGNDATDSFRIYYFMLLGIM------ASLSAQAW 641
            ...|::|.|..| :|.:.:...:..:|...:||.:..|:   .:|..:||:      .||.....
Yeast   866 PLAYYISKIMSEVVPLRVVPPILLSLIVYPMTGLNMKDN---AFFKCIGILILFNLGISLEILTI 927

  Fly   642 GFF---VGATLPTKLAVFLGPILAVMFSVFGFCTRYIDITPL-FRWMWHLSYFRAGFHGAL-NAI 701
            |..   :..::...:.|.||.:|   ||  |......:||.: |:::.:.|.|...:...| |.:
Yeast   928 GIIFEDLNNSIILSVLVLLGSLL---FS--GLFINTKNITNVAFKYLKNFSVFYYAYESLLINEV 987

  Fly   702 ---------YGMDRPFLECPETAMYCHFRSPKVFLKYMMISDVHMSDCLILMGIVIGVMHVLTL 756
                     ||::   :|.|...:...|.    |:...::.|:.:   |.|..:|..:|..|.|
Yeast   988 KTLMLKERKYGLN---IEVPGATILSTFG----FVVQNLVFDIKI---LALFNVVFLIMGYLAL 1041

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17646	NP_608618.1	ABCG_EPDR	103..333	CDD:213180	88/236 (37%)
		3a01204	123..765	CDD:273361	191/697 (27%)
		ABC2_membrane	497..698	CDD:279410	51/214 (24%)
ADP1	NP_009937.2	EGF_CA	<70..>90	CDD:419698
ADP1	NP_009937.2	3a01204	402..1042	CDD:273361	190/693 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	1	1.000	-	-		otm46658
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X52
TreeFam	0	0.000	Not matched by this tool.
	5	4.810