DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17646 and ABCG2

DIOPT Version :9

Sequence 1:	NP_608618.1	Gene:	CG17646 / 33354	FlyBaseID:	FBgn0264494	Length:	766	Species:	Drosophila melanogaster
Sequence 2:	NP_181272.1	Gene:	ABCG2 / 818312	AraportID:	AT2G37360	Length:	755	Species:	Arabidopsis thaliana

Alignment Length:	785	Identity:	193/785 - (24%)
Similarity:	328/785 - (41%)	Gaps:	167/785 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 DETSSTSSRGSCELTSKVTNDLNGFQSPNYHQAVAHANFDHCDPVDIQFADVRYTV---KKF--- 118
            ||::|:.:.|   :.|.:.:..:.|.|    .|.|.|:.....|..:.|.|:.|:|   |||
plant    59 DESASSRALG---IASPINSAASSFNS----WASAPASSISSSPFVLSFTDLTYSVKIQKKFNPL 116

  Fly   119 -----SFPERKFVTKEILHGLNGSFRSGELTAIMGPSGAGKSTLLNVMSG-FCSTGVSGDIRVNR 177
                 |..:....||.:|:|::|..|.||:.|::|.||:|||||::.::. .....:.|.|.:|.
plant   117 ACCRRSGNDSSVNTKILLNGISGEAREGEMMAVLGASGSGKSTLIDALANRIAKDSLRGSITLNG 181

  Fly   178 KPMAPSSERFRQMLCYIHQDDLLRPQLLVGEIMLLAAHLKLGFKVTKAYKMDLIKHILSLLGLDH 242
            :.:..|.::.  :..|:.|||||.|.|.|.|.::.:|..:|...::|..|...::.::..|||..
plant   182 EVLESSMQKV--ISAYVMQDDLLFPMLTVEETLMFSAEFRLPRSLSKKKKKARVQALIDQLGLRS 244

  Fly   243 RYNVPTGK-----LSGGQKKRLAIALELISNPPVLYLDEPTTGLDSSSCSSCVALLKKLASQGHT 302
            ......|.     :|||:::|::|..::|.:|.:|:|||||:||||:|....:.:|:::|..|..
plant   245 AAKTVIGDEGHRGVSGGERRRVSIGNDIIHDPIILFLDEPTSGLDSTSAYMVIKVLQRIAQSGSI 309

  Fly   303 IVCTIHQPSALIFEMFDKLYTVVDGHCMYQGPVRELVPFLADQQLVCPSYHNPADYLLEVAVGEH 367
            ::.:|||||..|..:.|:|..:..|:.:|.|....|..|.::.:...|...|..::.|
plant   310 VIMSIHQPSYRIMGLLDQLIFLSKGNTVYSGSPTHLPQFFSEFKHPIPENENKTEFAL------- 367

  Fly   368 QRDLNELIHAANKKYYEDVDRHRYMSSDDMARLVESIKE---------NMGGKAVVKTSEALAAF 423
                             |:.|....|::....|||..|:         |...|.....|....|.
plant   368 -----------------DLIRELEYSTEGTKPLVEFHKQWRAKQAPSYNNNNKRNTNVSSLKEAI 415

  Fly   424 AAAQFSSFDYVKPSPQELALEEIKALSGGPESADPDLLEKNLRPQPQPLAKAGELARPPNAIRSA 488
            .|                ::...|.:||...:.     ..||.|..|..|.
plant   416 TA----------------SISRGKLVSGATNNN-----SSNLTPSFQTFAN-------------- 445

  Fly   489 SFLMQYVLLMQRILICAKRNYFLLLARIFSHIFIGVVFGYLYMNVGNN---AQSVLGNYVYLYGS 550
            .|.::.:::.:|.::.::|...||..|:.:.:..|::...::.|:.|:   ||..||.:.:...:
plant   446 PFWIEMIVIGKRAILNSRRQPELLGMRLGAVMVTGIILATMFTNLDNSPKGAQERLGFFAFAMST 510

  Fly   551 TLLLVYTGKMAVVLTFPLEIDMLTREHFNRWYKLGPYFLSLISFEIPFQSLCTAMYIIISVHLTG 615
            |.   ||...|:.: |..|..:..||.....|:...|.||.....||...:.:|.:...:....|
plant   511 TF---YTCAEAIPV-FLQERYIFMRETAYNAYRRSSYVLSQSIISIPALIVLSASFAATTFWAVG 571

  Fly   616 ND-ATDSFRIYYFMLLGIMASLSAQAWGFFVGATLPTKLA-----VFLG-----PILA--VMFSV 667
            .| ..:.|..:||.:|.          .|:.|::..|.|:     |.||     .|||  ::||.
plant   572 LDGGANGFFFFYFTILA----------SFWAGSSFVTFLSGVIPNVMLGFTVVVAILAYFLLFSG 626

  Fly   668 FGFCTRYIDITPLFRWMW--HLSYFRAGFHGAL-NAIYGMDR------------PFLECPE---- 713
            | |.:|  |..|:: |:|  ::|..:..:.|.| |......|            |..|.|.
plant   627 F-FISR--DRIPVY-WLWFHYISLVKYPYEGVLQNEFQNPTRCFARGVQLFDNSPLGEFPNDVKV 687

  Fly   714 --------------TAMYCHFRSPKVFLKYMMISDVHMSDCL---ILMGIVIGVMHVLTLITLWH 761
                          ||..|......: ||...|:|:...:||   :..|....|:...||  |..
plant   688 NLLKSMSGVLGTNVTAETCVTTGIDI-LKQQGITDISKWNCLWITVAWGFFFRVLFYFTL--LIG 749

  Fly   762 KLNKR 766
            ..|||
plant   750 SKNKR 754

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17646	NP_608618.1	ABCG_EPDR	103..333	CDD:213180	79/246 (32%)
		3a01204	123..765	CDD:273361	171/708 (24%)
		ABC2_membrane	497..698	CDD:279410	54/218 (25%)
ABCG2	NP_181272.1	3a01204	95..754	CDD:273361	181/740 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48041
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.920