DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17646 and Abcg8

DIOPT Version :9

Sequence 1:	NP_608618.1	Gene:	CG17646 / 33354	FlyBaseID:	FBgn0264494	Length:	766	Species:	Drosophila melanogaster
Sequence 2:	NP_080456.1	Gene:	Abcg8 / 67470	MGIID:	1914720	Length:	673	Species:	Mus musculus

Alignment Length:	695	Identity:	162/695 - (23%)
Similarity:	283/695 - (40%)	Gaps:	109/695 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 IQFADVRYTV------------KKFSFPERKFVTKEI----LHGLNGSFRSGELTAIMGPSGAGK 154
            ::..|:.|.|            .:|..|.|...:::.    :..|:...|||::.||:|.||.|:
Mouse    48 LEVRDLTYQVDIASQVPWFEQLAQFKIPWRSHSSQDSCELGIRNLSFKVRSGQMLAIIGSSGCGR 112

  Fly   155 STLLNVMSGFCSTG--VSGDIRVNRKPMAPSSERFRQMLCYIHQDDLLRPQLLVGEIMLLAAHLK 217
            ::||:|::|....|  .||.|.:|.:|..|  :..|:.:.::.|.|.|.|.|.|.|.:...|.::
Mouse   113 ASLLDVITGRGHGGKMKSGQIWINGQPSTP--QLVRKCVAHVRQHDQLLPNLTVRETLAFIAQMR 175

  Fly   218 LGFKVTKAYKMDLIKHILSLLGLDHRYNVPTGK-----LSGGQKKRLAIALELISNPPVLYLDEP 277
            |....::|.:...::.:::.|.|....|...|.     :|||:::|::|.::|:.||.:|.||||
Mouse   176 LPRTFSQAQRDKRVEDVIAELRLRQCANTRVGNTYVRGVSGGERRRVSIGVQLLWNPGILILDEP 240

  Fly   278 TTGLDSSSCSSCVALLKKLASQGHTIVCTIHQPSALIFEMFDKLYTVVDGHCMYQGPVRELVPFL 342
            |:||||.:..:.|..|.:||.....::.::|||.:.||.:||.:..:..|..:|.|..:::|.:.
Mouse   241 TSGLDSFTAHNLVTTLSRLAKGNRLVLISLHQPRSDIFRLFDLVLLMTSGTPIYLGAAQQMVQYF 305

  Fly   343 ADQQLVCPSYHNPADYLLEVAVGEHQRDLNELIHAANKKYYEDVDRHRYMSSDDMARLVESIKEN 407
            ......||.|.||||:.:::.                     .:||..              ||.
Mouse   306 TSIGHPCPRYSNPADFYVDLT---------------------SIDRRS--------------KER 335

  Fly   408 MGGKAVVKTSEALAAFAAAQFSSFDYVKPSPQELALEEIKALSGGPESADPDLLEKNLRPQPQPL 472
              ..|.|:.:::|||....:...||      ..|...|.|.|:....:....|.:.
Mouse   336 --EVATVEKAQSLAALFLEKVQGFD------DFLWKAEAKELNTSTHTVSLTLTQD--------- 383

  Fly   473 AKAGELARPPNAIRSASFLMQYVLLMQRILICAKRNYFLLLARIFSHIFIGVVFGYLYMNVGNNA 537
            ...|.....|..|.      |:..|::|.:....|:...||........:.::.|:||...|...
Mouse   384 TDCGTAVELPGMIE------QFSTLIRRQISNDFRDLPTLLIHGSEACLMSLIIGFLYYGHGAKQ 442

  Fly   538 QSVLGNYVYLYGSTLLLVYTGKMAVVLTFPLEIDMLTREHFNRWYKLGPYFLSLISFEIPFQSLC 602
            .|.:.....|:....|:.:...:.||.....|..||..|..:..|..||||.:.|..|:|.....
Mouse   443 LSFMDTAALLFMIGALIPFNVILDVVSKCHSERSMLYYELEDGLYTAGPYFFAKILGELPEHCAY 507

  Fly   603 TAMYIIISVHLTGNDATDSFRIYYFMLLGIMASLSAQAWGFFVGATLPT--KLAVFLGPILAVMF 665
            ..:|.:....||.........:.:|:|:.::. ...:.......|.|||  ..:.|...:....:
Mouse   508 VIIYAMPIYWLTNLRPVPELFLLHFLLVWLVV-FCCRTMALAASAMLPTFHMSSFFCNALYNSFY 571

  Fly   666 SVFGFCTRYIDITPLFRWMWHLSYFRAGFHGALNAIYGMDRPFLECPETAMYCHFRSPKV----- 725
            ...||.....::..:..|:..||:.|..|.|.:...:.              .|..:.::
Mouse   572 LTAGFMINLDNLWIVPAWISKLSFLRWCFSGLMQIQFN--------------GHLYTTQIGNFTF 622

  Fly   726 -FLKYMMIS--DVHMSDCLILMGIVIGVMH-VLTLITLWHKLNKR 766
             .|...|||  |::......:..||||:.: .|.|..|..||.|:
Mouse   623 SILGDTMISAMDLNSHPLYAIYLIVIGISYGFLFLYYLSLKLIKQ 667

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17646	NP_608618.1	ABCG_EPDR	103..333	CDD:213180	73/249 (29%)
		3a01204	123..765	CDD:273361	156/663 (24%)
		ABC2_membrane	497..698	CDD:279410	44/202 (22%)
Abcg8	NP_080456.1	ABCG_White	71..296	CDD:213201	70/226 (31%)
		3a01204	89..664	CDD:273361	153/649 (24%)
		ABC2_membrane	402..606	CDD:279410	44/204 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X52
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.820