DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17646 and ABCG4

DIOPT Version :9

Sequence 1:	NP_608618.1	Gene:	CG17646 / 33354	FlyBaseID:	FBgn0264494	Length:	766	Species:	Drosophila melanogaster
Sequence 2:	NP_001135977.1	Gene:	ABCG4 / 64137	HGNCID:	13884	Length:	646	Species:	Homo sapiens

Alignment Length:	734	Identity:	263/734 - (35%)
Similarity:	373/734 - (50%)	Gaps:	113/734 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 GC-LGINCCTTAASSELSIDETSSTSSRGSCELTSKVTNDLNGFQSPNYHQAVAHANFDHC---D 102
            || ||......|.:.|...:....|:.      ..||.|.:...|           .|.|.   .
Human    10 GCGLGPGAVAMAVTLEDGAEPPVLTTH------LKKVENHITEAQ-----------RFSHLPKRS 57

  Fly   103 PVDIQFADVRYTVKKFSFPERKFVTKEILHGLNGSFRSGELTAIMGPSGAGKSTLLNVMSGFCST 167
            .|||:|.::.|:|::... .||...|.:|..|:|.|...||..|||||||||||.:|:::|:..:
Human    58 AVDIEFVELSYSVREGPC-WRKRGYKTLLKCLSGKFCRRELIGIMGPSGAGKSTFMNILAGYRES 121

  Fly   168 GVSGDIRVNRKPMAPSSERFRQMLCYIHQDDLLRPQLLVGEIMLLAAHLKLGFKVTKAYKMDLIK 232
            |:.|.|.||.:|.  ....||:|.|||.|||:|.|.|.|.|.|:::|:|||..|  :..|.:|:.
Human   122 GMKGQILVNGRPR--ELRTFRKMSCYIMQDDMLLPHLTVLEAMMVSANLKLSEK--QEVKKELVT 182

  Fly   233 HILSLLGLDHRYNVPTGKLSGGQKKRLAIALELISNPPVLYLDEPTTGLDSSSCSSCVALLKKLA 297
            .||:.|||....:..|..|||||:|||||||||::||||::.||||:||||:||...|:|:|.||
Human   183 EILTALGLMSCSHTRTALLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKSLA 247

  Fly   298 SQGHTIVCTIHQPSALIFEMFDKLYTVVDGHCMYQGPVRELVPFLADQQLVCPSYHNPADYLLEV 362
            ..|.||:||||||||.:||||||||.:..|.|:::|.|..|:|:|....|.||:||||||:::||
Human   248 QGGRTIICTIHQPSAKLFEMFDKLYILSQGQCIFKGVVTNLIPYLKGLGLHCPTYHNPADFIIEV 312

  Fly   363 AVGEHQRDLNELIHAANKKYYEDVDRHRYMSSDDMARLVESIKENMGGKAVVKTSEALAAFAAAQ 427
            |.||: .|||.::..|                                     ....|.|.|..
Human   313 ASGEY-GDLNPMLFRA-------------------------------------VQNGLCAMAEK- 338

  Fly   428 FSSFDYVKPSPQELALEEIKALSGGPESADPDLLEKNLRPQPQPLAKAGELARPP--NAIRSASF 490
                   |.||                       |||..|.|.|..       ||  :.|.|.:|
Human   339 -------KSSP-----------------------EKNEVPAPCPPC-------PPEVDPIESHTF 366

  Fly   491 ----LMQYVLLMQRILICAKRNYFLLLARIFSHIFIGVVFGYLYMNVGNNAQSVLGNYVYLYGST 551
                |.|:.:|.:|..:...|:..|...|..||:.|||:.|.||:::|::|..|..|...|:.|.
Human   367 ATSTLTQFCILFKRTFLSILRDTVLTHLRFMSHVVIGVLIGLLYLHIGDDASKVFNNTGCLFFSM 431

  Fly   552 LLLVYTGKMAVVLTFPLEIDMLTREHFNRWYKLGPYFLSLISFEIPFQSLCTAMYIIISVHLTGN 616
            |.|::...|..|||||||:.:..|||.|.||.|..|:|:....::|||.:|..:|..|...:||.
Human   432 LFLMFAALMPTVLTFPLEMAVFMREHLNYWYSLKAYYLAKTMADVPFQVVCPVVYCSIVYWMTGQ 496

  Fly   617 DATDSFRIYYFMLLGIMASLSAQAWGFFVGATLPT-KLAVFLGPILAVMFSVF-GFCTRYIDITP 679
            .|..| |...|..|....:|.||:.|..:||...: ::|.|:||:.|:...:| ||...:..|..
Human   497 PAETS-RFLLFSALATATALVAQSLGLLIGAASNSLQVATFVGPVTAIPVLLFSGFFVSFKTIPT 560

  Fly   680 LFRWMWHLSYFRAGFHGALNAIYGMDRPFLECPETAMYCHFRSPKVFLKYMMISDVHMSDCLILM 744
            ..:|..:|||.|.||.|.:..||||:|..|.|.|..  |.||.|:..|:.:.:.|..:....:::
Human   561 YLQWSSYLSYVRYGFEGVILTIYGMERGDLTCLEER--CPFREPQSILRALDVEDAKLYMDFLVL 623

  Fly   745 GIVIGVMHVLTLITLWHKL 763
            ||....:.:|..:.|.:::
Human   624 GIFFLALRLLAYLVLRYRV 642

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17646	NP_608618.1	ABCG_EPDR	103..333	CDD:213180	116/229 (51%)
		3a01204	123..765	CDD:273361	244/649 (38%)
		ABC2_membrane	497..698	CDD:279410	74/202 (37%)
ABCG4	NP_001135977.1	3a01204	44..646	CDD:273361	253/694 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177791at33208
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48041
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X52
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.920