DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17646 and abcg2c

DIOPT Version :9

Sequence 1:	NP_608618.1	Gene:	CG17646 / 33354	FlyBaseID:	FBgn0264494	Length:	766	Species:	Drosophila melanogaster
Sequence 2:	XP_005156580.1	Gene:	abcg2c / 569858	ZFINID:	ZDB-GENE-050517-37	Length:	640	Species:	Danio rerio

Alignment Length:	688	Identity:	178/688 - (25%)
Similarity:	309/688 - (44%)	Gaps:	142/688 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 ELSIDETSSTSSRGS--CELTSKVTNDLNGFQSPNYHQAVAHANFDHCDPVDIQFADVRYTVKK- 117
            |:.::|.|||.:..|  |            ||:|.              |. :.|..:||.:|:
Zfish    10 EVVVNEQSSTDADESVPC------------FQTPG--------------PT-VTFHQIRYRIKER 47

  Fly   118 ---FSFPERKFVTKEILHGLNGSFRSGELTAIMGPSGAGKSTLLNVMSG-------------FCS 166
               ||...|:   |:||..::|....| :.|||||:|:||::||:|::|             ..:
Zfish    48 LGMFSCQWRE---KDILKDVSGIMNPG-MNAIMGPTGSGKTSLLDVIAGRKDPKGLKSGQVLVDN 108

  Fly   167 TGVSGDIRVNRKPMAPSSERFRQMLC--YIHQDDLLRPQLLVGEIMLLAAHLKLGFKVTKAYKMD 229
            |.|:.|:|                ||  |:.|:|:|...|.|.|.:..:|:|:|..|...:...:
Zfish   109 TIVTSDLR----------------LCSAYVVQNDILMGTLTVRENLAFSANLRLSLKEYSSSDKE 157

  Fly   230 L-IKHILSLLGLDHRYNVPTGKL-----SGGQKKRLAIALELISNPPVLYLDEPTTGLDSSSCSS 288
            : :..::..|||....:...|.:     |||:|||.:|.:|||::|.:|:|||||||||:::.:|
Zfish   158 MRVNSVIQELGLKDCADTKIGTMFLRGVSGGEKKRCSIGMELITSPSLLFLDEPTTGLDANTANS 222

  Fly   289 CVALLKKLASQGHTIVCTIHQPSALIFEMFDKLYTVVDGHCMYQGPVRELVPFLADQQLVCPSYH 353
            .:.||:.::.:|.|::.:||||...||..||.|..:..|..:|.|...:.:.:..|....|..::
Zfish   223 IMELLQNISKKGKTVIFSIHQPRYSIFRQFDHLTLMNKGEIIYAGAADKAIIYFEDLGYKCEPFN 287

  Fly   354 NPADYLLEVAVGEHQRDLNELIHAANKKYYEDVDRHRYMSSDDMARLVESIKENMGGKAVVKTSE 418
            ||||:.|:|..|                   .:..|:  ||::::....|.:|      :|....
Zfish   288 NPADFFLDVTNG-------------------TIRPHK--SSNNISEKCSSSEE------MVDNEN 325

  Fly   419 ALAAFAAAQFSSFDYVKPSPQELALEE-IKALSGGPESADPDLLEKNLRPQPQPLAKAGELARPP 482
            .||..          .:.||....|:: :..:|.|   .||::.:.:         |.| .|.|
Zfish   326 PLAVM----------YRKSPYFTKLKDRLTEISDG---LDPEVTKGD---------KIG-YATP- 366

  Fly   483 NAIRSASFLMQYVLLMQRILICAKRNYFLLLARIFSHIFIGVVFGYLYMNVGNNAQSVLGNYVYL 547
                   |..|.:|:..|.:....||.....|::|.:||.|::.|.:|..:.:.....|.|....
Zfish   367 -------FYYQLLLVSGRTIRNILRNPQTSYAQLFLNIFFGILVGLIYYQIPHTLPEALQNRTGA 424

  Fly   548 YGSTLLLVYTGKMAVVLTFPLEIDMLTREHFNRWYKLGPYFLSLISFE-IPFQSLCTAMYIIISV 611
            :...::.:..|.::.|..|..|.::...|:.:.:|:...||||.:..: ||.:.|...::..|..
Zfish   425 FFFLVINMVFGNLSAVELFVSERELFIHENSSGFYRTSAYFLSKVFADLIPNRILPVFIFSAIPY 489

  Fly   612 HLTG-NDATDSFRIYYFMLLGIMASLSAQAWGFFVGATLPT-KLAVFLGPILAVMFSVF-GFCTR 673
            .:.| ....::|.:|...:  .|.||||.:..|.|.|::.: .:|..|..:..|...|| ||...
Zfish   490 FMMGLKPEVEAFFLYCVTM--SMVSLSAVSLAFLVSASVGSFAMANILIALPYVFMMVFGGFLVN 552

  Fly   674 YIDITPLFRWMWHLSYFRAGFHG-ALNAIYGMDRPFLE 710
            ...:.....|:...|.||.|::. |:|.:  .|:.|.:
Zfish   553 LNSMLSGLSWLKWASIFRYGYNALAINEL--KDQVFTD 588

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17646	NP_608618.1	ABCG_EPDR	103..333	CDD:213180	83/254 (33%)
		3a01204	123..765	CDD:273361	161/615 (26%)
		ABC2_membrane	497..698	CDD:279410	49/205 (24%)
abcg2c	XP_005156580.1	ABCG_EPDR	34..267	CDD:213180	82/253 (32%)
		3a01204	37..638	CDD:273361	167/634 (26%)
		ABC2_membrane	377..579	CDD:279410	50/203 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X52
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.820