DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17646 and abcg4a

DIOPT Version :9

Sequence 1:	NP_608618.1	Gene:	CG17646 / 33354	FlyBaseID:	FBgn0264494	Length:	766	Species:	Drosophila melanogaster
Sequence 2:	XP_687685.2	Gene:	abcg4a / 564842	ZFINID:	ZDB-GENE-050517-39	Length:	641	Species:	Danio rerio

Alignment Length:	720	Identity:	263/720 - (36%)
Similarity:	379/720 - (52%)	Gaps:	102/720 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 SSELSIDETSSTSSRGSCELT--SKVTNDLNGFQSPNYHQAVAHANFDHC---DPVDIQFADVRY 113
            |..:.::||..... .:..||  .||.|.:...|           .|.|.   ..||::|.::.|
Zfish    10 SVSIPMEETKRAGG-DAAMLTHLKKVENHITEAQ-----------RFSHLPRRSTVDLEFTELSY 62

  Fly   114 TVKKF-SFPERKFVTKEILHGLNGSFRSGELTAIMGPSGAGKSTLLNVMSGFCSTGVSGDIRVNR 177
            |:::. .:..|.|  |.:|..|:|.|.|.||..||||||||||||:|:::|:..||:.|.|.||.
Zfish    63 TIREGPCWRRRGF--KALLKCLSGKFCSRELIGIMGPSGAGKSTLMNILAGYRETGMKGQILVNG 125

  Fly   178 KPMAPSSERFRQMLCYIHQDDLLRPQLLVGEIMLLAAHLKLGFKVTKAYKMDLIKHILSLLGLDH 242
            :|.  ....||:|.|||.|||:|.|.|...|.|:::|:|||...:  ..|.:|:..||:.|||..
Zfish   126 RPR--DLRTFRKMSCYIMQDDMLLPHLTTREAMMVSANLKLNENM--EVKKELVNEILTALGLQE 186

  Fly   243 RYNVPTGKLSGGQKKRLAIALELISNPPVLYLDEPTTGLDSSSCSSCVALLKKLASQGHTIVCTI 307
            .....|..|||||.|||||||||::||||::.||||:||||:||...|:|:|.||..|.||:|||
Zfish   187 CAQTRTISLSGGQCKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKSLAQGGRTIICTI 251

  Fly   308 HQPSALIFEMFDKLYTVVDGHCMYQGPVRELVPFLADQQLVCPSYHNPADYLLEVAVGEHQRDLN 372
            |||||.:||||||||.:..|.|:|:|.|..|:|:|.:..|.||:||||||:::|||.||: .|||
Zfish   252 HQPSAKLFEMFDKLYILSQGQCIYKGTVPYLIPYLKNLGLHCPTYHNPADFIIEVASGEY-GDLN 315

  Fly   373 ELIHAANKKYYEDVDRHRYMSSDDMARLVESIKENMGGKAVVKTSEALAAFAAAQFSSFDYVKPS 437
            .::       :|.|...  :.|||.       |:|...|....||
Zfish   316 PVL-------FEAVQGG--LCSDDS-------KKNSSDKNDPTTS-------------------- 344

  Fly   438 PQELALEEIKALSGGPESADPD--LLEKNLRPQPQPLAKAGELARPPNAIRSASFLMQYVLLMQR 500
                          .|....||  .:||:                    ..:.|.|.|:.:|.:|
Zfish   345 --------------CPSQCYPDSGYIEKH--------------------TFATSTLTQFCILFKR 375

  Fly   501 ILICAKRNYFLLLARIFSHIFIGVVFGYLYMNVGNNAQSVLGNYVYLYGSTLLLVYTGKMAVVLT 565
            ..|...|:..|...|:.||:.|||:.|.||:|:||:|..|..|..:|:.|.|.|::...|..|||
Zfish   376 TFITICRDVVLTHLRVMSHLCIGVLIGLLYLNIGNDASKVFNNTGFLFFSMLFLMFAALMPTVLT 440

  Fly   566 FPLEIDMLTREHFNRWYKLGPYFLSLISFEIPFQSLCTAMYIIISVHLTGNDATDSFRIYYFMLL 630
            ||||:.:..|||.|.||.|..|:|:....:||||.:|..||..|...:| ....::.|...||.|
Zfish   441 FPLEMGVFIREHLNYWYSLKAYYLAKTMADIPFQVICPIMYCSIVYWMT-EQPPEAGRYLLFMAL 504

  Fly   631 GIMASLSAQAWGFFVG-ATLPTKLAVFLGPILAVMFSVF-GFCTRYIDITPLFRWMWHLSYFRAG 693
            ....:|.||:.|..:| |:...::|.|:||:.|:...:| ||...:..|....:|..::||.|.|
Zfish   505 STSTALVAQSLGLLIGAASTSLQVATFVGPVSAIPVLLFSGFFVNFDTIPKYLQWSSYVSYVRYG 569

  Fly   694 FHGALNAIYGMDRPFLECPETAMYCHFRSPKVFLKYMMISDVHMSDCLILMGIVIGVMHVLTLIT 758
            |.|.:.:||||:|..||||  .:.|.|:.|:..|:.:.:.|..:....:::|:...|:.:.|...
Zfish   570 FEGVILSIYGMNRSELECP--GIVCKFQKPEEVLQLLDVEDAKLYVDFMVLGVFFLVLRLATYFV 632

  Fly   759 LWHKL 763
            |.:|:
Zfish   633 LRYKV 637

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17646	NP_608618.1	ABCG_EPDR	103..333	CDD:213180	117/230 (51%)
		3a01204	123..765	CDD:273361	247/645 (38%)
		ABC2_membrane	497..698	CDD:279410	76/202 (38%)
abcg4a	XP_687685.2	3a01204	38..641	CDD:273361	255/691 (37%)
		ABCG_EPDR	53..277	CDD:213180	117/229 (51%)
		ABC2_membrane	372..574	CDD:279410	76/202 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177791at33208
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48041
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X52
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	6.020