DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17646 and abcg1

DIOPT Version :9

Sequence 1:	NP_608618.1	Gene:	CG17646 / 33354	FlyBaseID:	FBgn0264494	Length:	766	Species:	Drosophila melanogaster
Sequence 2:	NP_001103924.1	Gene:	abcg1 / 556979	ZFINID:	ZDB-GENE-070424-84	Length:	673	Species:	Danio rerio

Alignment Length:	744	Identity:	266/744 - (35%)
Similarity:	394/744 - (52%)	Gaps:	122/744 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 DPDSGCLGINCCTTAASSELSIDETSSTSSRGSCELTSKVTNDLNGFQSPNYHQAVAHANFDHCD 102
            ||.:.|:.|:   ...|:.:|..:|....:.     ..||.|:|...|..:|        .....
Zfish    32 DPRTVCVSID---EMMSNHVSSQQTPLLHAH-----LKKVENNLTEAQRFSY--------LPRRP 80

  Fly   103 PVDIQFADVRYTVKKFSFPE----RKFVTKEILHGLNGSFRSGELTAIMGPSGAGKSTLLNVMSG 163
            .|:|:|.|:.|:|     ||    ||...|.:|.|::|:|..|.|.|||||||||||||:|:::|
Zfish    81 AVNIEFKDLSYSV-----PEGPWWRKKGYKTLLKGISGNFTGGALVAIMGPSGAGKSTLMNILAG 140

  Fly   164 FCSTGVSGDIRVNRKPMAPSSERFRQMLCYIHQDDLLRPQLLVGEIMLLAAHLKLGFKVTKAYKM 228
            :..||:.|:|.:|..|....|  ||::.|||.|||:|.|.|.|.|.|:::|:|||..|  ...:.
Zfish   141 YRETGMKGEILINGHPRDLRS--FRKVSCYIMQDDMLLPHLTVQEAMMVSANLKLQEK--DEGRR 201

  Fly   229 DLIKHILSLLGLDHRYNVPTGKLSGGQKKRLAIALELISNPPVLYLDEPTTGLDSSSCSSCVALL 293
            ::::.||:.|||.......|..|||||:|||||||||::||||::.||||:|||||||...|:|:
Zfish   202 EMVREILTALGLLECAKTRTSHLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSSSCFQVVSLM 266

  Fly   294 KKLASQGHTIVCTIHQPSALIFEMFDKLYTVVDGHCMYQGPVRELVPFLADQQLVCPSYHNPADY 358
            |.||..|.|::||||||||.:||:|||||.:..|.|:|:|.|..|:|:|.|..|.||:||||||:
Zfish   267 KALAQGGRTVICTIHQPSAKVFELFDKLYVLSQGQCIYRGKVSSLIPYLRDLGLSCPTYHNPADF 331

  Fly   359 LLEVAVGEHQRDLNELIHAANKKYYEDVDRHRYMSSDDMARLVESIKEN---------MGGKAVV 414
            ::|||.||:                          .|..||||::::|:         |.|..|
Zfish   332 IMEVASGEY--------------------------GDQTARLVKAVQEHKCEKDYKTEMNGNGV- 369

  Fly   415 KTSEALAAFAAAQFSSFDYVKPSPQELALEEIKALSGGPESADPDLLEKNLRPQPQPLAKAGELA 479
                         .:.|.:.:||.:|.:..|      |..|.
Zfish   370 -------------HNPFLWHRPSDEESSSSE------GCHSF----------------------- 392

  Fly   480 RPPNAIRSASFLMQYVLLMQRILICAKRNYFLLLARIFSHIFIGVVFGYLYMNVGNNAQSVLGNY 544
                   |||.|.|:.:|.:|..:...|:..|...||.||:.||::.|.||:.:||.|:.||.|.
Zfish   393 -------SASCLTQFCILFKRTFLSIMRDSVLTHLRIMSHLGIGILIGLLYLGIGNEAKKVLSNS 450

  Fly   545 VYLYGSTLLLVYTGKMAVVLTFPLEIDMLTREHFNRWYKLGPYFLSLISFEIPFQSLCTAMYIII 609
            .:|:.|.|.|::...|..|||||||:.:..|||.|.||.|..|:|:....::|||.:....|..|
Zfish   451 GFLFFSMLFLMFAALMPTVLTFPLEMGVFLREHLNYWYSLKAYYLAKTMADVPFQIVFPVAYCSI 515

  Fly   610 SVHLTGNDATDSFRIYYFMLLGIMASLSAQAWGFFVG-ATLPTKLAVFLGPILAVMFSVF-GFCT 672
            ...:| :..:|:.|...|:.||.:.||.||:.|..:| |:...::|.|:||:.|:...:| ||..
Zfish   516 VYWMT-SQPSDAVRFILFLALGTLTSLVAQSLGLLIGAASTSLQVATFVGPVTAIPVLLFSGFFV 579

  Fly   673 RYIDITPLFRWMWHLSYFRAGFHGALNAIYGMDRPFLEC--PETAMYCHFRSPKVFLKYMMISDV 735
            .:..|....:|:.::||.|.||.|.:.:|||:||..|.|  .||   |||:..:..||.:.:.|.
Zfish   580 SFDTIPKYLQWISYISYVRYGFEGVILSIYGLDREDLHCDKDET---CHFQKSEAILKELDVEDA 641

  Fly   736 HMSDCLILMGIVIGVMHVLTLITLWHKLN 764
            .:....|::||....:.::....|.:|::
Zfish   642 KLYMDFIVLGIFFISLRLIAYFVLRYKIS 670

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17646	NP_608618.1	ABCG_EPDR	103..333	CDD:213180	118/233 (51%)
		3a01204	123..765	CDD:273361	245/655 (37%)
		ABC2_membrane	497..698	CDD:279410	74/202 (37%)
abcg1	NP_001103924.1	3a01204	67..673	CDD:273361	256/701 (37%)
		ABCG_EPDR	81..306	CDD:213180	118/233 (51%)
		ABC2_membrane	403..605	CDD:279410	74/202 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48041
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X52
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	7	6.880