DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17646 and E23

DIOPT Version :9

Sequence 1:	NP_608618.1	Gene:	CG17646 / 33354	FlyBaseID:	FBgn0264494	Length:	766	Species:	Drosophila melanogaster
Sequence 2:	NP_524648.3	Gene:	E23 / 43895	FlyBaseID:	FBgn0020445	Length:	1017	Species:	Drosophila melanogaster

Alignment Length:	841	Identity:	210/841 - (24%)
Similarity:	353/841 - (41%)	Gaps:	177/841 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 SDAACCVGGANSDASSSSGVCSLKGHHGDPDSGCLGINCCTTAASSELSIDETSSTSSRGSCELT 74
            |||......|:||:|:||...|.........|........||..|::      :.|||.|...:.
  Fly   239 SDATAATSVASSDSSASSSASSTSSSSSSSTSSEFTHTSQTTIPSTD------NLTSSNGLANIG 297

  Fly    75 SKVTNDL--NGFQSPNYH--------QAVAHANFDHCD--------------PVDIQFADVRYTV 115
            ..:..|.  |...|.:||        |...|.|.:.|:              .:.:.|.::....
  Fly   298 KSILVDAKSNSPASLSYHFEKSAAANQQKQHHNINICNSHHPHHHSQNQPQHSLQLTFQNLNVLH 362

  Fly   116 KKFSFPERKFVTKEILHGLNGSFRSGELTAIMGPSGAGKSTLLNVMSGFCSTGVSGDIRVNRKPM 180
            .:          ::||..::|.....|:.|||||||:||:|||:.:||..... ||.:.:||:|:
  Fly   363 NE----------RQILSDVSGFVSPCEVLAIMGPSGSGKTTLLDCLSGQRHID-SGSVFLNREPL 416

  Fly   181 APSSERFRQMLCYIHQDDLLRPQLLVGEIMLLAAHLKLGFKVTKAYKMDLIKHILSLLGLDHRYN 245
               ::::|:.:.|:.|:::..|||.:.|.::..|.|:|...:.:|.||..:.|||..|.|.....
  Fly   417 ---TKKWRRRIGYVLQEEIFFPQLTLRETVVYTALLRLPESMPRAEKMRQVDHILEALELGCCQQ 478

  Fly   246 VPTGK-----LSGGQKKRLAIALELISNPPVLYLDEPTTGLDSSSCSSCVALLKKLAS-QGHTIV 304
            ...|.     ||||:|||..||.||::||.::.|||||:||||.|..|.:.:||:.|. :..|||
  Fly   479 TKFGDYLNRGLSGGEKKRANIACELLTNPLLMLLDEPTSGLDSHSAISLMKVLKRYAQLEQKTIV 543

  Fly   305 CTIHQPSALIFEMFDKLYTVVDGHCMYQGPVRELVPFLADQQLVCPSYHNPADYLLEV------- 362
            .::||||:.:|.|||||..:..|...|.|.|:.:.....|..:....::||||::||.
  Fly   544 ISVHQPSSQMFHMFDKLLLLHQGRTAYFGDVQNIYRHFEDIGVTIKPHYNPADFVLEQLKSHPDI 608

  Fly   363 ---------------------------------AVGEHQRD---LNELIHAANKKYYEDVDRHRY 391
                                             |.|:.|.|   ::::|   |..|.:..:||.:
  Fly   609 REKLFIAAKESHGNYLNRNCITSSHHNQVSVSGAKGKKQADSILIDDII---NNYYNQRSNRHHH 670

  Fly   392 MSSDDMARLVESIKENMGGKAVVKTSEA---LAAFAAAQFSSFDYVKPSPQELALEEIKALSGGP 453
            .        .|::.....|..|.:..||   |...||...|:|.....|.    .....|.||..
  Fly   671 Q--------YENLHHTSNGCRVEEDEEAAQHLVWCAADSQSNFSSCASSD----CHSYSAGSGPG 723

  Fly   454 ESADPDLLEKNLRPQPQPLAKAGELARPPNAIRSASFLMQYVLLMQRILICAKRNYFLLLARI-- 516
            .|||.|.|.                       ...||..|:.:|..|....||..   :|:::
  Fly   724 HSADDDWLS-----------------------YPTSFHTQFCVLSSRNFREAKPR---MLSKLNW 762

  Fly   517 FSHIFIGVVFGYLYMNVGNNAQSVLGNYVYLYGSTLLLVYTGKMAVVLTFPLEIDMLTREHFNRW 581
            |..|.:.::.|.::..:....:.:.....:::.|....:.......:.:||.|.:::::|..:..
  Fly   763 FQTIGLALMAGAIWFQLPRTEEFLHDLQGWMFFSQTYWMLFALFGALNSFPSEREVVSKERRSGA 827

  Fly   582 YKLGPYFLSLISFEIPFQSLCTAMYIIISVHLTGNDATDSFRIYYFMLLGIMA-SLSAQAWGFFV 645
            |:|..|:|:.:..|:|.......:|::||..:.|   ..|.::::.||:.::. ::.||:.|||:
  Fly   828 YRLSAYYLAKMCAELPLVITLPTVYLMISYPMLG---CTSLKLFFLMLIFLLINTIVAQSVGFFI 889

  Fly   646 GA-TLPTKLAVFLGPILAVMFSVFGFCTRYID--ITPLFRW-----MWHLSY-------FRAGFH 695
            || .:...:::.|..:..:...:||   .|:.  |.....|     |.|.:|       ||.|
  Fly   890 GACCMDMNVSITLSALYTLATQLFG---GYLSSRIPEGLSWIRYTSMIHYAYQNMQILEFREG-- 949

  Fly   696 GALNAIYGMDRPFLECPETAMY--CHFRSPKVFLKYMMISDVHMSDCLILMGIVIGVMHVL 754
                |..|       |...:.|  |..:|.: |:.|..|.....|...:.:..:|.:|..|
  Fly   950 ----AAIG-------CGSPSSYEICKQQSTE-FIPYEEILKAQNSTSPLWLNTLILMMFFL 998

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17646	NP_608618.1	ABCG_EPDR	103..333	CDD:213180	85/235 (36%)
		3a01204	123..765	CDD:273361	182/704 (26%)
		ABC2_membrane	497..698	CDD:279410	45/218 (21%)
E23	NP_524648.3	ABCG_EPDR	350..572	CDD:213180	85/235 (36%)
		3a01204	363..1009	CDD:273361	182/711 (26%)
		ABC2_membrane	744..943	CDD:279410	42/207 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	42	1.000	Domainoid score	I3665
eggNOG	1	0.900	-	-		E2759_KOG0061
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48041
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X52
	7	6.920