DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17646 and w

DIOPT Version :9

Sequence 1:	NP_608618.1	Gene:	CG17646 / 33354	FlyBaseID:	FBgn0264494	Length:	766	Species:	Drosophila melanogaster
Sequence 2:	NP_476787.1	Gene:	w / 31271	FlyBaseID:	FBgn0003996	Length:	687	Species:	Drosophila melanogaster

Alignment Length:	761	Identity:	184/761 - (24%)
Similarity:	320/761 - (42%)	Gaps:	138/761 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 HHGDPDSGCLGINCCTTAAS-----SELSIDETSSTSSRGSCELTSKVT---NDLNGFQSPN--- 88
            |..:.|||....:|......     ..|........|..||.:|...:|   ::::.|.:.|
  Fly    21 HLNNGDSGAASQSCINQGFGQAKNYGTLRPPSPPEDSGSGSGQLAENLTYAWHNMDIFGAVNQPG 85

  Fly    89 --YHQAVAHANFDHCDPVDIQFADVRYTVKKFSFPERKFVT--KEILHGLNGSFRSGELTAIMGP 149
              :.|.|.......|:                   ||....  |.:|..:.|....|||.|:||.
  Fly    86 SGWRQLVNRTRGLFCN-------------------ERHIPAPRKHLLKNVCGVAYPGELLAVMGS 131

  Fly   150 SGAGKSTLLNVMSGFCSTGV----SGDIRVNRKPMAPSSERFRQMLCYIHQDDLLRPQLLVGEIM 210
            |||||:||||.::.....|:    ||...:|.:|:  .::..:....|:.||||....|...|.:
  Fly   132 SGAGKTTLLNALAFRSPQGIQVSPSGMRLLNGQPV--DAKEMQARCAYVQQDDLFIGSLTAREHL 194

  Fly   211 LLAAHLKLGFKVT---KAYKMDLIKHILSLLGLDHRYNVPTGK---LSGGQKKRLAIALELISNP 269
            :..|.:::...:|   :..::|.:...|||....|......|:   ||||::||||.|.|.:::|
  Fly   195 IFQAMVRMPRHLTYRQRVARVDQVIQELSLSKCQHTIIGVPGRVKGLSGGERKRLAFASEALTDP 259

  Fly   270 PVLYLDEPTTGLDSSSCSSCVALLKKLASQGHTIVCTIHQPSALIFEMFDKLYTVVDGHCMYQGP 334
            |:|..||||:||||.:..|.|.:||||:.:|.|::.||||||:.:||:|||:..:.:|...:.|.
  Fly   260 PLLICDEPTSGLDSFTAHSVVQVLKKLSQKGKTVILTIHQPSSELFELFDKILLMAEGRVAFLGT 324

  Fly   335 VRELVPFLADQQLVCPSYHNPADYLLEVAVGEHQRDLNELIHAANKKYYEDVDRHRYMSSDDMAR 399
            ..|.|.|.:.....||:.:||||:.::|......|::            |..||
  Fly   325 PSEAVDFFSYVGAQCPTNYNPADFYVQVLAVVPGREI------------ESRDR----------- 366

  Fly   400 LVESIKENMGGKAVVKTSEALAAFAAAQFSSFDYVKPSPQELALEEIKALSGGPESADPDLLEKN 464
             :..|.:|.....|.:..|.|                                       |..||
  Fly   367 -IAKICDNFAISKVARDMEQL---------------------------------------LATKN 391

  Fly   465 LRPQPQPLAKAGELARPPNAIR-SASFLMQYVLLMQRILICAKRNYFLLLARIFSHIFIGVVFGY 528
            |.   :|      |.:|.|... .|::.||:..::.|..:...:...|:..|:.....:.::.|.
  Fly   392 LE---KP------LEQPENGYTYKATWFMQFRAVLWRSWLSVLKEPLLVKVRLIQTTMVAILIGL 447

  Fly   529 LYMNVGNNAQSV----LGNYVYLYGSTLLLVYTGKMAVVLTFPLEIDMLTREHFNRWYKLGPYFL 589
            :::  |.....|    :...::|:.:.  :.:....|.:..|..|:.:..||..:|.|:...|||
  Fly   448 IFL--GQQLTQVGVMNINGAIFLFLTN--MTFQNVFATINVFTSELPVFMREARSRLYRCDTYFL 508

  Fly   590 SLISFEIPFQSLCTAMYIIISVHLTGNDATDSFRIYYF---MLLGIMASLSAQAWGFFVG-ATLP 650
            .....|:|.......::..|:..:.|..|.   .:::|   .|:.::|::|. ::|:.:. |:..
  Fly   509 GKTIAELPLFLTVPLVFTAIAYPMIGLRAG---VLHFFNCLALVTLVANVST-SFGYLISCASSS 569

  Fly   651 TKLAVFLGPILAVMFSVF-GFCTRYIDITPLFRWMWHLSYFRAGFHGAL-NAIYGMDRPFLECPE 713
            |.:|:.:||.:.:.|.:| ||......:....:|:.:||:||....|.| |....::...:.|..
  Fly   570 TSMALSVGPPVIIPFLLFGGFFLNSGSVPVYLKWLSYLSWFRYANEGLLINQWADVEPGEISCTS 634

  Fly   714 TAMYCHFRSPKVFLKYMMISDVHMSDCLILMGIVIGVMHVLTLITL 759
            :...|. .|.||.|:.:..|...:....:.:.|:|....||..:.|
  Fly   635 SNTTCP-SSGKVILETLNFSAADLPLDYVGLAILIVSFRVLAYLAL 679

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17646	NP_608618.1	ABCG_EPDR	103..333	CDD:213180	81/241 (34%)
		3a01204	123..765	CDD:273361	167/660 (25%)
		ABC2_membrane	497..698	CDD:279410	42/209 (20%)
w	NP_476787.1	3a01204	68..687	CDD:273361	174/714 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	1	1.000	-	-		mtm14984
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48041
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X52
	7	6.920