DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17646 and Abcg4

DIOPT Version :9

Sequence 1:	NP_608618.1	Gene:	CG17646 / 33354	FlyBaseID:	FBgn0264494	Length:	766	Species:	Drosophila melanogaster
Sequence 2:	NP_001100286.2	Gene:	Abcg4 / 300664	RGDID:	1305840	Length:	646	Species:	Rattus norvegicus

Alignment Length:	734	Identity:	260/734 - (35%)
Similarity:	374/734 - (50%)	Gaps:	113/734 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 GC-LGINCCTTAASSELSIDETSSTSSRGSCELTSKVTNDLNGFQSPNYHQAVAHANFDHC---D 102
            || ||......|.:.|...:....|:.      ..||.|.:...|           .|.|.   .
  Rat    10 GCGLGPGAVAMAVALEDGAEPPVLTTH------LKKVENHITEAQ-----------RFSHLPKRS 57

  Fly   103 PVDIQFADVRYTVKKFSFPERKFVTKEILHGLNGSFRSGELTAIMGPSGAGKSTLLNVMSGFCST 167
            .|||:|.::.|:|::... .||...|.:|..|:|.|...||..|||||||||||.:|:::|:..:
  Rat    58 AVDIEFVELSYSVREGPC-WRKRGYKTLLKCLSGKFCRRELIGIMGPSGAGKSTFMNILAGYRES 121

  Fly   168 GVSGDIRVNRKPMAPSSERFRQMLCYIHQDDLLRPQLLVGEIMLLAAHLKLGFKVTKAYKMDLIK 232
            |:.|.|.||.:|.  ....||:|.|||.|||:|.|.|.|.|.|:::|:|||..|  :..|.:|:.
  Rat   122 GMKGQILVNGRPR--DLRTFRKMSCYIMQDDMLLPHLTVLEAMMVSANLKLSEK--QEVKKELVT 182

  Fly   233 HILSLLGLDHRYNVPTGKLSGGQKKRLAIALELISNPPVLYLDEPTTGLDSSSCSSCVALLKKLA 297
            .||:.|||....:..|..|||||:|||||||||::||||::.||||:||||:||...|:|:|.||
  Rat   183 EILTALGLMSCSHTRTALLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKSLA 247

  Fly   298 SQGHTIVCTIHQPSALIFEMFDKLYTVVDGHCMYQGPVRELVPFLADQQLVCPSYHNPADYLLEV 362
            ..|.|::||||||||.:||||||||.:..|.|:::|.|..|:|:|....|.||:||||||:::||
  Rat   248 HGGRTVICTIHQPSAKLFEMFDKLYILSQGQCIFKGVVTNLIPYLKGLGLHCPTYHNPADFIIEV 312

  Fly   363 AVGEHQRDLNELIHAANKKYYEDVDRHRYMSSDDMARLVESIKENMGGKAVVKTSEALAAFAAAQ 427
            |.||: .|||.::..|                                     ....|...|..
  Rat   313 ASGEY-GDLNPMLFRA-------------------------------------VQNGLCTMAEK- 338

  Fly   428 FSSFDYVKPSPQELALEEIKALSGGPESADPDLLEKNLRPQPQPLAKAGELARPP--NAIRSASF 490
                   |.||                       |||..|...|..       ||  :.|.|.:|
  Rat   339 -------KSSP-----------------------EKNEVPAHCPTC-------PPELDPIESHTF 366

  Fly   491 ----LMQYVLLMQRILICAKRNYFLLLARIFSHIFIGVVFGYLYMNVGNNAQSVLGNYVYLYGST 551
                |.|:.:|.:|..:...|:..|...|..||:.|||:.|.||:::|::|..|..|..:|:.|.
  Rat   367 ATSTLTQFCILFRRTFLSILRDTVLTHLRFMSHVLIGVLIGLLYLHIGDDASKVFNNTGFLFFSM 431

  Fly   552 LLLVYTGKMAVVLTFPLEIDMLTREHFNRWYKLGPYFLSLISFEIPFQSLCTAMYIIISVHLTGN 616
            |.|::...|..|||||||:.:..|||.|.||.|..|:|:....::|||.:|..:|..|...:||.
  Rat   432 LFLMFAALMPTVLTFPLEMAVFMREHLNYWYSLKAYYLAKTMADVPFQVVCPVVYCSIVYWMTGQ 496

  Fly   617 DATDSFRIYYFMLLGIMASLSAQAWGFFVG-ATLPTKLAVFLGPILAVMFSVF-GFCTRYIDITP 679
            .|..| |...|..|.|..:|.||:.|..:| |:...::|.|:||:.|:...:| ||...:..|..
  Rat   497 PAETS-RFLLFSALSIATALVAQSLGLLIGAASTSLQVATFVGPVTAIPVLLFSGFFVSFKTIPT 560

  Fly   680 LFRWMWHLSYFRAGFHGALNAIYGMDRPFLECPETAMYCHFRSPKVFLKYMMISDVHMSDCLILM 744
            ..:|..:|||.|.||.|.:..||||:|..|.|.|.  :|.||.|::.|..:.:.:..:....:::
  Rat   561 YLQWSSYLSYVRYGFEGLILTIYGMERGHLTCLED--HCPFRDPQIILHELDVEEAKLYMDFLVL 623

  Fly   745 GIVIGVMHVLTLITLWHKL 763
            ||....:.:|..:.|.:::
  Rat   624 GIFFLALRLLAYLVLRYRV 642

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17646	NP_608618.1	ABCG_EPDR	103..333	CDD:213180	115/229 (50%)
		3a01204	123..765	CDD:273361	241/649 (37%)
		ABC2_membrane	497..698	CDD:279410	75/202 (37%)
Abcg4	NP_001100286.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177791at33208
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48041
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X52
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	8	7.880