DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17646 and Abca17

DIOPT Version :9

Sequence 1:	NP_608618.1	Gene:	CG17646 / 33354	FlyBaseID:	FBgn0264494	Length:	766	Species:	Drosophila melanogaster
Sequence 2:	NP_001026807.1	Gene:	Abca17 / 287112	RGDID:	1560494	Length:	1773	Species:	Rattus norvegicus

Alignment Length:	852	Identity:	169/852 - (19%)
Similarity:	309/852 - (36%)	Gaps:	262/852 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 HCDPVDIQFADVRYTVKKFSFPERKFVTKEILHGLNGSFRSGELTAIMGPSGAGKSTLLNVMSGF 164
            |.:.::||     :..|.|.....|.:.   :..|:.:...|::|.::|.:||||:|:.:|::|.
  Rat   521 HINAIEIQ-----HLYKVFYTGRSKCIA---VKDLSMNLYKGQITVLLGHNGAGKTTVCSVLTGL 577

  Fly   165 CSTGVSGDIRVNRKPMAPSSERFRQMLCYIHQDDLLRPQLLVGEIMLLAAHLKLGFKVTKAYKMD 229
            .... .|...::...::....|.|:.:.:..|.|:|.....|.:.:.....|| |......:  :
  Rat   578 IPPS-KGHAYIHGCEISKDMVRIRKNVGWCPQHDILFDNFTVTDHLYFYGQLK-GLSHQDCH--E 638

  Fly   230 LIKHILSLLGLDHRYNVPTGKLSGGQKKRLAIALELISNPPVLYLDEPTTGLDSSSCSSCVALLK 294
            .|:.:|..|||:.:.|..:..||||.|::|||.:.||:...||.|||||:|:||||..:...||:
  Rat   639 KIEEMLHTLGLEDKRNSRSKFLSGGMKRKLAIGIALIAGSKVLILDEPTSGMDSSSRRAIWDLLQ 703

  Fly   295 KLASQGHTIVCTIHQPSALIFE---MFDKLYTVVDGHCMYQGPVREL--------------VPFL 342
            :.... .|::.|.|    .:.|   :.|::..:..|.....|....|              .|..
  Rat   704 QQKGD-RTVLLTTH----FMDEADLLGDRIAILAKGELQCCGTPSFLKQKYGAGYYMTIIKTPLC 763

  Fly   343 ADQQLVCPSYHNPADYLLEVAVGEHQRDLNELIHAANKKYYEDVDRHRYMSSDDMARLVESIKEN 407
            ..::|....||:..:.:||..:||      |:|....||   .:.|...:.:|     :|..:..
  Rat   764 DTEKLAKVIYHHIPNAILESRIGE------EMIFTLPKK---AMPRFEALFAD-----LEQRQTE 814

  Fly   408 MG----GKAVVKTSEA---LAAFAAAQFSSFDYVKPSPQEL------ALEEIKALSGGPESADPD 459
            :|    |.:|....|.   :...|....:.....:||.:.|      .::.||.|.....|...|
  Rat   815 LGISTFGASVTTMEEVFIRVCKLADPSTNVLTEKRPSLRHLPRNHRVPVDRIKCLHSRIFSLSSD 879

  Fly   460 LLEKNLRPQPQPLAKAGELARPPNAIRSASFLMQ--YVLLMQRILICAKRNYFLLLARIFSHIFI 522
                                :|.......|.|.|  |.:|::::.. ::||:.|:|:   ..|.:
  Rat   880 --------------------QPIRLNTGFSLLCQQFYAMLLKKVAF-SRRNWMLVLS---VQILL 920

  Fly   523 GVVFGYLYMNVGNNAQSVLGNY-----VYLYGSTL---------------------LLVYTGKMA 561
            .:|...|.::..|.....|.|.     :..||.|:                     :||..|::.
  Rat   921 PLVIIMLSLSFFNFKLRKLDNVPLELTLQTYGQTIVPFFIAENSRLDPQLSDNFVKMLVAAGQVP 985

  Fly   562 VVLTFPLEIDMLTR-----EHFNRWYKLGPYF------------------------LSLISFEIP 597
            :.:...:|..:|.:     |.|::.|.:...|                        |:|:. .:.
  Rat   986 LRIQGSVENFLLKKAKEAPEDFDKLYVVAASFEDVNDHTTVKALFNNQAYHSPSLALALVD-NVL 1049

  Fly   598 FQSLC---------------TAM--------------YIII-------------SVHLTGNDATD 620
            |:.|.               |||              |:::             |:...|..:..
  Rat  1050 FKLLSGANASITTTNYPQPQTAMELSETILYQGPKGHYLVVNFLFGIAFLSSSFSILTVGEKSIK 1114

  Fly   621 SFRIYYFMLLGI-MAS--LSAQAWGFFVGATLPTKLAVFLG--------------PILAVMFSVF 668
            |..:.:  |.|: ||:  |||..|. .:...:||.|.|.:.              |.:.::..::
  Rat  1115 SKNLQF--LSGVSMAAFWLSALLWD-LISFLVPTLLLVLVFFWYKEEAFAHPQSIPAVVLIMMLY 1176

  Fly   669 GFCTRYIDITPLFRWMWHLSY-FRAGFHGALNAIY----------------------------GM 704
            |:.     |.||   ::.:|: |:....|.:..:.                            .:
  Rat  1177 GWA-----IIPL---VYTVSFSFKTPGSGCVKLVAMLTFLSISPVVLVTVTSEIDLGYTELSDTL 1233

  Fly   705 DRPFLECPE-------TAMYCHFRSPKVFLKYMMISDVHMSDCLILMGIVI----------GVMH 752
            |..||..|.       :.:|.:|...| |.....:||:..:|  :|.|.|:          |:..
  Rat  1234 DHIFLIFPGHCLGMAFSNLYYNFEIKK-FCNAKNLSDIDCND--VLEGYVVQKNIYAWESLGIGK 1295

  Fly   753 VLTLITL 759
            .||.:.:
  Rat  1296 YLTALAI 1302

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17646	NP_608618.1	ABCG_EPDR	103..333	CDD:213180	62/232 (27%)
		3a01204	123..765	CDD:273361	164/829 (20%)
		ABC2_membrane	497..698	CDD:279410	54/315 (17%)
Abca17	NP_001026807.1	ABC2_membrane_3	<262..464	CDD:289468
		ABC_subfamily_A	525..746	CDD:213230	63/237 (27%)
		drrA	543..834	CDD:130256	78/316 (25%)
		ABC2_membrane_3	913..1255	CDD:289468	55/356 (15%)
		CcmA	1369..1682	CDD:224054
		ABC_subfamily_A	1369..1590	CDD:213230
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1690..1773
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000