DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17646 and pdr1

DIOPT Version :9

Sequence 1:	NP_608618.1	Gene:	CG17646 / 33354	FlyBaseID:	FBgn0264494	Length:	766	Species:	Drosophila melanogaster
Sequence 2:	NP_593995.1	Gene:	pdr1 / 2543363	PomBaseID:	SPAPB24D3.09c	Length:	1396	Species:	Schizosaccharomyces pombe

Alignment Length:	759	Identity:	156/759 - (20%)
Similarity:	284/759 - (37%)	Gaps:	225/759 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 DIQFADVRYTVKKFSFPERKFVTKEILHGLNGSFRSGELTAIMGPSGAGKSTLLNVMS--GFCST 167
            |:.|..|..|.|           |:||..::|..:...|||::|.:.:|||.||.::|  |...:
pombe   762 DLNFTVVTKTSK-----------KQILTNVSGYLKKNTLTALLGENKSGKSVLLRILSQRGIAGS 815

  Fly   168 GVSGDIRVN--RKPMAPSSERFRQMLCYIHQDDLLRPQLLVGEIMLLAAHLKLGFKVTKAYKMDL 230
             |.|:|.::  :.|     :..|:.:.|:.::.|...:..|.|.:.|.|.|:...:.:.:.:...
pombe   816 -VEGEITLSGLKNP-----KNLRKRIGYVRKNPLFISEYTVRETLRLHAALRQSKQRSLSEQYAY 874

  Fly   231 IKHILSLLGLDHRYNVPTGKLSGG----QKKRLAIALELISNP-PVLYLDEPTTGLDSSSCSSCV 290
            :::::..|||....:...|.:..|    .|:.|:||:||.:.| .:|.||||..||||.|....|
pombe   875 VEYVIDFLGLGEVADFIVGDMGKGLSLYHKRLLSIAVELSARPGSILLLDEPANGLDSQSAWMLV 939

  Fly   291 ALLKKLASQGHTIVCTIHQPSALIFEMFDKLYTV-VDGHCMYQGPVRELVPFLADQQLVCPSYHN 354
            .:|:|||..|.:|:|::.|||:.|.|:||.:..: ::|:.:|...:
pombe   940 CILQKLARSGLSILCSVSQPSSRILELFDMMLILDLNGNTVYYDTM------------------- 985

  Fly   355 PADYLLEVAVGEHQRDLNELIHAANKKYYEDV---DRHRYMSSDDMARLVESIKENMGGKAVVKT 416
                         .|||::|::     |::.:   :.|...::|.:...::.:|
pombe   986 -------------GRDLSKLVN-----YFKRIHGTNEHSKDTADFVLHCIQFLK----------- 1021

  Fly   417 SEALAAFAAAQFSSFDY----VKPSPQELALEEIKALSGGPESADPDLLEKNLRPQPQPLAKAGE 477
                      |...|||    ...:..:..:|.:..:...||..|.|.
pombe  1022 ----------QGPEFDYAGAWASTNTHKQIIEHVNFIMDNPELTDDDF----------------- 1059

  Fly   478 LARPPNAIR-SASFLMQYVLLMQRILICAKRNYFLLLARIFSHIFIGVVFGYLY----MNVGNNA 537
                ||..| ..||..|...:..|..:...|:..||.||:..:|..|::.|:.:    :.|....
pombe  1060 ----PNETRFMTSFFFQIYKISMRNFVAYWRDSSLLRARVAFNIVAGLIIGFSFYKQGVGVEETQ 1120

  Fly   538 QSVLGNYVYLYGSTLLL----------------------VYTGKMAVVLTFPLEIDM----LTRE 576
            ..:...|:....||..:                      :|:....::..|.:|..:    .|..
pombe  1121 NKMFSAYMLTVASTSTMNGLQPKFIYFRSIYEQYEQNTAIYSRTAFIIAFFLVEAVINCCFATLF 1185

  Fly   577 HFNRWYKLGPYFLSLISFEIPFQSLCTAMYIIISVHLTGNDATDSFRIYYFML----------LG 631
            .|..:|..|.|   ..:..|||......:.::|            |.:||..|          :|
pombe  1186 FFGWYYPSGFY---EFNHNIPFYGGFAWLMLMI------------FTLYYTTLGIGIATISPSIG 1235

  Fly   632 IMASLSAQAW-------------GFFVG------ATLPTK--LAVFLG------PILAVMFSVFG 669
            ..:.:|..|:             |..||      |..|.|  |...:|      ||....|.:
pombe  1236 TASIISGTAFVFIQYFNGMIQLPGVIVGFWKWMDALSPYKYFLEGMIGGVLHDAPITCEKFEI-- 1298

  Fly   670 FCTRYIDITPLFR-WMWHLSYFRAGFHGALNAIYGMDRPFLECPETAMYCHFRSPKVFLKYMMIS 733
               .|:|..|.:. ..:..|:..:..||   .:|..     |...:..||.:::..   :.|:..
pombe  1299 ---HYVDPPPNYSCGEYFSSFLNSSGHG---IVYNP-----EAYSSCQYCPYKNAD---ELMVGF 1349

  Fly   734 DVHMSD-----CLIL------MGIVIGVMHVLTLITLWHKLNKR 766
            ..|.:.     |:::      :|..|.:.:::.. |.|.:|..|
pombe  1350 GYHYNHKWRNFCIMIGYTAFNLGAAIALYYIIHK-TPWKRLAAR 1392

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17646	NP_608618.1	ABCG_EPDR	103..333	CDD:213180	71/237 (30%)
		3a01204	123..765	CDD:273361	150/738 (20%)
		ABC2_membrane	497..698	CDD:279410	49/268 (18%)
pdr1	NP_593995.1	3a01205	40..1382	CDD:273362	152/746 (20%)
		ABCG_PDR_domain1	70..302	CDD:213200
		ABC2_membrane	421..620	CDD:279410
		PDR_CDR	634..>701	CDD:283960
		ABCG_PDR_domain2	755..983	CDD:213199	71/237 (30%)
		ABC2_membrane	1076..1284	CDD:279410	39/222 (18%)
		PDR_CDR	<1349..>1377	CDD:283960	4/27 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	59	1.000	Domainoid score	I3039
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X52
TreeFam	0	0.000	Not matched by this tool.
	2	2.000