DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17646 and bfr1

DIOPT Version :9

Sequence 1:	NP_608618.1	Gene:	CG17646 / 33354	FlyBaseID:	FBgn0264494	Length:	766	Species:	Drosophila melanogaster
Sequence 2:	NP_587932.3	Gene:	bfr1 / 2539195	PomBaseID:	SPCC18B5.01c	Length:	1530	Species:	Schizosaccharomyces pombe

Alignment Length:	850	Identity:	203/850 - (23%)
Similarity:	318/850 - (37%)	Gaps:	232/850 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 NSDASSSSGVCSLKGHH------GDPDSGCLGINCCTTAASSELSIDETSSTSSRGSCELTSKVT 78
            |..||.:.....|||.:      ..||:....:|........|...|.......:.|.:...::.
pombe   805 NIVASETLNFNDLKGEYLVFRRGHAPDAVKAAVNEGGKPLDLETGQDTQGGDVVKESPDNEEELN 869

  Fly    79 NDLNGFQSPNYHQAVAHANFDHCDPVDIQFADVRYTVKKFSFPERKFVTKEILHGLNGSFRSGEL 143
            .:..|.:..  |...:..|.::    |||.               |...:.:|:|:.|....|:|
pombe   870 KEYEGIEKG--HDIFSWRNLNY----DIQI---------------KGEHRRLLNGVQGFVVPGKL 913

  Fly   144 TAIMGPSGAGKSTLLNVMSGFCSTG-VSGDIRVNRKPMAPSSERFRQMLCYIHQDDLLRPQLLVG 207
            ||:||.|||||:|||||::....|| |:||:.||.:.:   ...|::...|:.|.|:...:..|.
pombe   914 TALMGESGAGKTTLLNVLAQRVDTGVVTGDMLVNGRGL---DSTFQRRTGYVQQQDVHIGESTVR 975

  Fly   208 EIMLLAAHLKLGFKVTKAYKMDLIKHILSLLGLDHR----YNVPTGKLSGGQKKRLAIALELISN 268
            |.:..:|.|:....|..:.|.:.::.::.||.::..    ...|...|:..|:||..|.:||.:.
pombe   976 EALRFSAALRQPASVPLSEKYEYVESVIKLLEMESYAEAIIGTPGSGLNVEQRKRATIGVELAAK 1040

  Fly   269 PP-VLYLDEPTTGLDSSSCSSCVALLKKLASQGHTIVCTIHQPSALIFEMFDKLYTV-VDGHCMY 331
            |. :|:|||||:||||.|..|.|..|:|||..|..|:||||||||::|:.||:|..: ..|..:|
pombe  1041 PALLLFLDEPTSGLDSQSAWSIVCFLRKLADAGQAILCTIHQPSAVLFDQFDRLLLLQKGGKTVY 1105

  Fly   332 QGPVRE----LVPFLADQQLV-CPSYHNPADYLLEV----AVGEHQRDLNELIHAANKKYYEDVD 387
            .|.:.|    |:.:......| ||...|||:|:|:|    |.....||.:|
pombe  1106 FGDIGEHSKTLLNYFESHGAVHCPDDGNPAEYILDVIGAGATATTNRDWHE-------------- 1156

  Fly   388 RHRYMSSDDMARLVESIKENMGGKAVVKTSEALAAFAAAQFSSFDYVKPSPQELALEEIKALSGG 452
                                     |...||...|.:|                .|::|.|....
pombe  1157 -------------------------VWNNSEERKAISA----------------ELDKINASFSN 1180

  Fly   453 PESADPDLLEKNLRPQPQPLAKAGELARPPNAIRSASFLMQYVLLMQRILICAKRNYFLLLARIF 517
            .|  |...|.|..|         ...|.|        ...|..::|.|......|...:|::::.
pombe  1181 SE--DKKTLSKEDR---------STYAMP--------LWFQVKMVMTRNFQSYWREPSILMSKLA 1226

  Fly   518 SHIFIGVVFGYLYMNVGNNAQSVLGNYVYLYGSTLLLVYTGKMAVVLTFPLEIDML--------- 573
            ..||.|:..|:.:.|.|...|::        .:.|..|:   ||.||..|| |:.|
pombe  1227 LDIFAGLFIGFTFYNQGLGVQNI--------QNKLFAVF---MATVLAVPL-INGLQPKFIELRN 1279

  Fly   574 ---TREHFNRWYKLGPYFLSLISFEIPFQSLCTAMYIII---------SVHLTGNDATDSFRIY- 625
               .||..:..|....:..|.|..||||..:...::.:.         .:|..|:....::.:|
pombe  1280 VFEVREKPSNIYSWVAFVFSAIIVEIPFNLVFGTLFFLCWFYPIKFYKHIHHPGDKTGYAWLLYM 1344

  Fly   626 ----YFMLLG-IMASLSAQA-WGFFVGATLPTKLAVFLGPILAVMFSVFGFCTRYIDITPLFRWM 684
                ||...| .:||....| ....|.:.|.|.:..|.| :|....::.||          :.||
pombe  1345 FFQMYFSTFGQAVASACPNAQTASVVNSLLFTFVITFNG-VLQPNSNLVGF----------WHWM 1398

  Fly   685 WHLSYFRAGFHGAL-NAIYGMDRPFLECPETAM-------------------------------- 716
            ..|:.|.....|.| :.::|:.   :||....|
pombe  1399 HSLTPFTYLIEGLLSDLVHGLP---VECKSHEMLTINPPSGQTCGEYMSAFLTNNTAAGNLLNPN 1460

  Fly   717 ------YCHFRSPKVFLKYMMISDVHMSDCLILMGIVIG--------------VMHVLTLITLWH 761
                  ||.:::...||:...:...|....|   ||.:|              |..|:.|.:.|
pombe  1461 ATTSCSYCPYQTADQFLERFSMRYTHRWRNL---GIFVGYVFFNIFAVLLLFYVFRVMKLRSTW- 1521

  Fly   762 KLNKR 766
             |.|:
pombe  1522 -LGKK 1525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17646	NP_608618.1	ABCG_EPDR	103..333	CDD:213180	84/236 (36%)
		3a01204	123..765	CDD:273361	184/738 (25%)
		ABC2_membrane	497..698	CDD:279410	52/228 (23%)
bfr1	NP_587932.3	ABC_trans_N	<102..160	CDD:291196
		3a01205	108..1516	CDD:273362	199/837 (24%)
		ABCG_PDR_domain1	166..392	CDD:213200
		ABC2_membrane	526..729	CDD:279410
		PDR_CDR	741..835	CDD:283960	8/29 (28%)
		ABCG_PDR_domain2	879..1107	CDD:213199	86/249 (35%)
		ABC2_membrane	1206..1413	CDD:279410	52/229 (23%)
		PDR_CDR	<1474..>1508	CDD:283960	7/36 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	59	1.000	Domainoid score	I3039
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X52
TreeFam	0	0.000	Not matched by this tool.
	3	2.900