DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17646 and abcx-1

DIOPT Version :9

Sequence 1:	NP_608618.1	Gene:	CG17646 / 33354	FlyBaseID:	FBgn0264494	Length:	766	Species:	Drosophila melanogaster
Sequence 2:	NP_495321.3	Gene:	abcx-1 / 183860	WormBaseID:	WBGene00006522	Length:	710	Species:	Caenorhabditis elegans

Alignment Length:	694	Identity:	153/694 - (22%)
Similarity:	249/694 - (35%)	Gaps:	184/694 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   126 VTKEILHGLNGSFRSGELTAIMGPSGAGKSTLLNVMSGFCST--GVSGDIRVNRKPMAPSSERFR 188
            |.|:.:|.::....|.::.|||....:...:||.::.|....  .:||||.||...|  |.:|..
Worm    95 VLKQEVHNISFELSSSDVLAIMYTKESETISLLKIICGIKDVRGKLSGDILVNGHRM--SRDRLE 157

  Fly   189 QMLCYIHQDDLLRPQLLVGEIMLLAAHLKLGFKVTKAY--KMDLIKHILSLLGLDHRYNVPTGKL 251
            :.:.::   .|..|...:.....|..|......:|:.|  ...||..:::.|||....::...:|
Worm   158 KTIGFV---SLESPTSTLSVRQYLHVHGNFYPPMTERYGGVGHLINKLMTDLGLFPVSDIICSRL 219

  Fly   252 SGGQKKRLAIALELISNPPVLYLDEPTTGLDSSSCSSCVALLKKLASQGHTIVCTIHQPSAL-IF 315
            :..|.:|:.:|.:|:.:|.:|...:....:|.......:..|::.|.:.:.||.....|::| |.
Worm   220 NRSQWQRVKVASQLVRDPTILVCSDIFKDIDVHDQCFLIDYLREWAVKTNRIVIMAISPTSLQIL 284

  Fly   316 EMFDKLYTVVDGHCMYQGPVRELVPFLADQQLVCPSYHNPADYLLEVAVGEHQRDLNELIHAANK 380
            .||.|...:..|..:|.||.:.:..:.......||.|.|..|
Worm   285 NMFSKAMILASGRMIYFGPPKSMQQYFETIGCPCPPYKNVCD----------------------- 326

  Fly   381 KYYEDVDRHRYMSSD-------DMARLVESIKENMGGKAVVKTSEALAAFAAAQFSSFDYVKPSP 438
             ||.|:..|..::||       .:||||.  |.|.....|.:|       |:.:|
Worm   327 -YYVDLVTHDNLTSDASRESSVRIARLVN--KWNQTAPPVRRT-------ASGKF---------- 371

  Fly   439 QELALEEIKALSGGPESADPDLLEKNLRPQPQPLAKAGELARPPNAIRSASFLMQYVLLMQRILI 503
                                 ||:         |..||...   |.:...| |..:..:..|
Worm   372 ---------------------LLD---------LPTAGIFM---NLLTLIS-LFWFNFINNR--- 399

  Fly   504 CAKRNYFLLLARIFS-------HIF-IGVVFGYLYMNVGNNAQSVLGNYVYLYGSTLLLVYTGKM 560
             |.|.:|||.  |||       |:. :.:.....::| .|:...:|..||.|:   :.||...|
Worm   400 -ASRIFFLLF--IFSLSTCLSLHLSDLSLTLPDAFLN-RNSYLELLIFYVPLF---IGLVNLKK- 456

  Fly   561 AVVLTFPLEID-----MLTREHFNRWYKLGP-------YFLSLISF--EIPF---QSLCTAMYII 608
               .||..|.|     :..|.|.....||.|       ..:.::||  |:||   .|:..||.:.
Worm   457 ---CTFLSEFDKFYLFISARHHLKELLKLSPLKNMCSSLSIIIVSFVVELPFLLITSMVFAMPMS 518

  Fly   609 I--------SVHLTGNDATDSFRIYYFMLLGI-------MASLSAQAWGFF------------VG 646
            |        |.|||   :..|....:|:.|.:       :::||::...||            .|
Worm   519 IFTDFHQKSSNHLT---SLVSISSSFFINLSVTQLVVNSVSNLSSEPLSFFFFVISWFSLFFACG 580

  Fly   647 ATLPT-KLAVFLGPILAVMFSVFGFCTRYIDITPLFRWMWHLSYFRAGFHGALN-----AIYGMD 705
            ...|. .:..:..|:.....|||.|.  |.|...|:..:            ::|     .:|...
Worm   581 FPFPIHSILKYFNPLFFPTTSVFRFL--YEDSPSLYPQL------------SVNLSTPIQLYSCG 631

  Fly   706 RPFLECPE-TAMYCHFRSPKVFLKYMMISDVHMSDCLILMGIVI 748
            |.||...: |...|...|....|.|...::.......|..||:|
Worm   632 RTFLNTTQVTRGPCQKVSSFELLSYYGFNESFDKQKSIFHGILI 675

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17646	NP_608618.1	ABCG_EPDR	103..333	CDD:213180	50/211 (24%)
		3a01204	123..765	CDD:273361	153/694 (22%)
		ABC2_membrane	497..698	CDD:279410	58/253 (23%)
abcx-1	NP_495321.3	P-loop_NTPase	102..302	CDD:304359	47/204 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820