DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17646 and wht-7

DIOPT Version :9

Sequence 1:	NP_608618.1	Gene:	CG17646 / 33354	FlyBaseID:	FBgn0264494	Length:	766	Species:	Drosophila melanogaster
Sequence 2:	NP_001367851.1	Gene:	wht-7 / 175864	WormBaseID:	WBGene00021535	Length:	666	Species:	Caenorhabditis elegans

Alignment Length:	693	Identity:	195/693 - (28%)
Similarity:	297/693 - (42%)	Gaps:	112/693 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 FDHCDPVDIQFADVRYTVKKFSFPERKFVTKEILHGLNGSFRSGELTAIMGPSGAGKSTLLNVMS 162
            |..|.|:.:  .||          |:..|.|.||..:.|..|.||:|||:|||||||:|||||::
Worm    61 FGKCCPIKV--GDV----------EKMSVEKRILDSVFGVARPGEVTAIIGPSGAGKTTLLNVLT 113

  Fly   163 --GFCSTGVSGDIRVNRKPMAPSSER--FRQMLCYIHQDDLLRPQLLVGEIMLLAAHLKLGFKVT 223
              ...:...:|.::||    ...:||  .||:..|:.|||.....|.|.|.:...|.||:|.:..
Worm   114 KRNLSNLKATGSVKVN----GIRAERSYMRQVCAYVQQDDCFIGSLTVEEHLKFMAKLKMGSEYD 174

  Fly   224 KAYKMDLIKHILSLLGL----DHRYNVPTGK-LSGGQKKRLAIALELISNPPVLYLDEPTTGLDS 283
            ...:...:|.::..|||    |......|.| :|||:|||||.|.|::::||:|..||||:||||
Worm   175 LNEQERRVKSVMRSLGLEKIADSIIGTRTRKGISGGEKKRLAFASEILTSPPILICDEPTSGLDS 239

  Fly   284 SSCSSCVALLKKLA-SQGHTIVCTIHQPSALIFEMFDKLYTVVDGHCMYQGPVRELVPFLADQQL 347
            ......|.:||||| ::..||:.||||||:.:|::||.:|.:|:|...:.|.........::.:|
Worm   240 FLAYQVVCVLKKLAETRNMTILLTIHQPSSQVFQLFDSIYMMVNGDVAFCGSQSGAEKMWSEMKL 304

  Fly   348 VCPSYHNPADYLLEVAVGEHQRDLNELIHAANKKYYEDVDRHRYMSSDDMARLVESIKENMGGKA 412
            ..|...||:|:.|..                             ||..|.|.  |::|:|..||.
Worm   305 PIPMNFNPSDHYLAT-----------------------------MSIRDQAE--ETLKKNQIGKI 338

  Fly   413 VVKTSEALAAFAAAQFSSFDYVKPSPQELALEEIKALSGGPESADPDLLEKNLRPQPQPLAKAGE 477
            .               ::|.|     .||.....|..||...........::.|.:     .|..
Worm   339 C---------------TTFKY-----SELGKSVFKESSGREVDERDRAFSEDWRRR-----YATT 378

  Fly   478 LARPPNAIRSASFLMQYVLLMQRILICAKRNYFLLLARIFSHIFIGVVFGYLY-----------M 531
            ..||.   ..|||..|...|..|......|...||..:.|..|.|.::.|.:|           |
Worm   379 FGRPR---FGASFFQQIRALTWRASKTVLREPTLLKVQTFQSIIIAILTGLVYTNNSPVDQQKIM 440

  Fly   532 NVGNNAQSVLGNYVYLYGSTLLLVYTGKMAVVLTFPLEIDMLTREHFNRWYKLGPYFLSLISFEI 596
            |:..:...::.|..:::          :.:||..|.||::...||..:|.|::..||:|....|:
Worm   441 NINGSLYQMISNMAFMF----------QFSVVHHFCLEMNTFYRETSSRLYRVSAYFISKNLAEL 495

  Fly   597 PFQSLCTAMYIIISVHLTG-NDATDSFRIYYFMLLGIMASLSAQAWGFFVGATLPT-KLAVFLGP 659
            |...:...::..|...::| ....|||.||  ||:||:....|.:.|:.......| .|||.:.|
Worm   496 PSYIVSAVIFTSILYWMSGLVPIIDSFLIY--MLVGILVQNIAISIGYMFSCIFGTVNLAVAVMP 558

  Fly   660 ILAVMFSVF-GFCTRYIDITPLFRWMWHLSYFRAGFHGALNAIYGMDRPFLECPETAMYCHFRSP 723
            |..|....| ||......:...|..|.:||||..|:.....|.:........|..:..:|. |:.
Worm   559 IFVVPMMAFGGFFINQDTLQWYFVPMKYLSYFGYGYEAVAIAQWTHVEEIPGCSSSLAHCS-RNG 622

  Fly   724 KVFLKYMMISDVHMSDCLILMGIVIGVMHVLTLITLWHKLNKR 766
            ...|..|.....:....:.:|..:|.|...|..:.|:.::.:|
Worm   623 TDVLNSMSFKPSNFWVDISVMAFMIFVFRFLAFMALYVRVKRR 665

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17646	NP_608618.1	ABCG_EPDR	103..333	CDD:213180	93/239 (39%)
		3a01204	123..765	CDD:273361	188/665 (28%)
		ABC2_membrane	497..698	CDD:279410	57/214 (27%)
wht-7	NP_001367851.1	3a01204	40..664	CDD:273361	194/690 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X52
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910