DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17646 and abcg8

DIOPT Version :9

Sequence 1:	NP_608618.1	Gene:	CG17646 / 33354	FlyBaseID:	FBgn0264494	Length:	766	Species:	Drosophila melanogaster
Sequence 2:	NP_001108041.2	Gene:	abcg8 / 100136850	ZFINID:	ZDB-GENE-050517-41	Length:	684	Species:	Danio rerio

Alignment Length:	664	Identity:	165/664 - (24%)
Similarity:	298/664 - (44%)	Gaps:	89/664 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   115 VKKFSFPERKFVTKE-ILHGLNGSFRSGELTAIMGPSGAGKSTLLNVMSGFCSTGV--SGDIRVN 176
            :.:|..|......|: ::..||....||::.|::|.||.||::||::::.....|.  ||:|.:|
Zfish    77 LSEFKMPWEMHSNKQTVIKDLNLHVHSGQMLAVIGSSGCGKTSLLDIITCRDEGGSMNSGEILIN 141

  Fly   177 RKPMAPSSERFRQMLCYIHQDDLLRPQLLVGEIMLLAAHLKLGFKVTKAYKMDLIKHILSLLGLD 241
            .||...|  ..::.:.::.|||.|.|.|.|.|.:...|.|:|....::..:...:..:::.|.|.
Zfish   142 GKPSTRS--LVKKSIAHVRQDDRLLPHLTVRETLAFVAKLRLPANFSQKQRDQRVDDVIAELRLR 204

  Fly   242 HRYNVPTGK-----LSGGQKKRLAIALELISNPPVLYLDEPTTGLDSSSCSSCVALLKKLASQGH 301
            ...:...|.     :|||:::|::||::|:.||.:|.|||||:||||.:..:.|..|.:||....
Zfish   205 QCAHTRVGNEYVRGVSGGERRRVSIAVQLLWNPGILILDEPTSGLDSFTAHNLVITLYRLARGNR 269

  Fly   302 TIVCTIHQPSALIFEMFDKLYTVVDGHCMYQGPVRELVPFLADQQLVCPSYHNPADYLLEVAVGE 366
            .::.::|||.:.||::||.:..:..|..:|.|..:::|.:.......||.|.||:||.:::.
Zfish   270 LVLLSVHQPRSDIFQLFDLVVLLSSGSAVYCGQAKDMVSYFTTLGYPCPRYCNPSDYYVDLI--- 331

  Fly   367 HQRDLNELIHAANKKYYEDVDRHRYMSSDDMARLVESIKENMGGKAVVKTSEALAAFAAAQFSSF 431
                              .:||.   :.:..|:.:|.                 |:..||||  .
Zfish   332 ------------------SIDRR---TPEKEAQCLEK-----------------ASMLAAQF--L 356

  Fly   432 DYVKPSPQELALEEI---KALSGGPESADPDLLEKNLRPQPQPLAKAGELARPPNAIRSASFLMQ 493
            :.||.:...:...|:   .||. .|:|:.|.:..|.     ..:..:.:..:.|..:.      |
Zfish   357 EKVKNNEDFMWKSEVCGPPALE-APQSSVPSVSMKE-----SVITVSKQKDQLPGKVH------Q 409

  Fly   494 YVLLMQRILICAKRNYFLLLARIFSHIFIGVVFGYLYMNVGNNAQSVLGNYVYLYGSTLLLVYTG 558
            :..|::|.:....|:...|:......:.:.::.|:||........|:......||....|..:..
Zfish   410 FTTLIRRQVFNDYRDLVTLVVHGLEALLMSLLIGFLYFGCTEEGLSIQDTVALLYMIGALTPFAV 474

  Fly   559 KMAVVLTFPLEIDMLTREHFNRWYKLGPYFLSLISFEIPFQSLCTAMYIIISVHLTG-NDATDSF 622
            .:.|:.....|..||..|..:..|.:.|||.:.:..|:|.....|.:|.:....|.| |.|.|.|
Zfish   475 VLDVIAKCHSERAMLYHELEDGMYSVTPYFFAKVLGELPEHCAFTLVYGVPIYWLAGLNVAPDRF 539

  Fly   623 RIYYFMLLGIMASLSAQAWGFFVGATLPT-KLAVFLGPILAVMFSVF----GFCTRYIDITPLFR 682
             :..|:|:.:....| ::...||.|.||| :.:.|:|..|   |:||    ||.....::..:..
Zfish   540 -LLNFLLVWLTVYCS-RSMALFVAAALPTLQTSSFMGNAL---FTVFYLTAGFVISLENMWMVAS 599

  Fly   683 WMWHLSYFRAGFHGALNAIYGMDRPFLECPETA--MYCHFRSPKVFLKYMMISDVHMSDC---LI 742
            |..::|:.|.||.|.|...:...|    .|.|.  :...|...|| ::.|.::...:..|   ||
Zfish   600 WFSYISFMRWGFEGMLQVQFRGTR----IPITIGNLTVEFDGIKV-VEMMKMNQYPLFSCYLVLI 659

  Fly   743 LMGIVIGVMHVLTL 756
            .:.:|..:::.|:|
Zfish   660 AVSLVFILLYYLSL 673

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17646	NP_608618.1	ABCG_EPDR	103..333	CDD:213180	69/225 (31%)
		3a01204	123..765	CDD:273361	163/656 (25%)
		ABC2_membrane	497..698	CDD:279410	53/206 (26%)
abcg8	NP_001108041.2	3a01204	47..674	CDD:273361	165/664 (25%)
		ABCG_White	72..301	CDD:213201	69/225 (31%)
		ABC2_membrane	413..617	CDD:279410	54/208 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X52
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.920