DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Eno and ERR3

DIOPT Version :9

Sequence 1:	NP_722721.1	Gene:	Eno / 33351	FlyBaseID:	FBgn0000579	Length:	500	Species:	Drosophila melanogaster
Sequence 2:	NP_014056.3	Gene:	ERR3 / 855373	SGDID:	S000004942	Length:	437	Species:	Saccharomyces cerevisiae

Alignment Length:	431	Identity:	256/431 - (59%)
Similarity:	321/431 - (74%)	Gaps:	2/431 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 MTIKAIKARQIYDSRGNPTVEVDLTTELGLFRAAVPSGASTGVHEALELRDNDKANYHGKSVLKA 132
            |:|..:.||.:|||||||||||::|||.|||||.||||||||:|||:||||.:|:.:.||.|.||
Yeast     1 MSITKVHARTVYDSRGNPTVEVEITTENGLFRAIVPSGASTGIHEAVELRDGNKSEWMGKGVTKA 65

  Fly   133 VGHVNDTLGPELIKANLDVVDQASIDNFMIKLDGTENKSKFGANAILGVSLAVAKAGAAKKGVPL 197
            |.:||..:||.|||::|.|.:|..||..||.||||.|||:.||||||||||.||:|.||:||:.|
Yeast    66 VSNVNSIIGPALIKSDLCVTNQKGIDELMISLDGTSNKSRLGANAILGVSLCVARAAAAQKGITL 130

  Fly   198 YKHIADLAGNKE--IILPVPAFNVINGGSHAGNKLAMQEFMILPTGATSFTEAMKMGSEVYHHLK 260
            ||:||:||..::  .::|||.|||:|||:|||..||||||.|.|.||.||.|||:||||||||||
Yeast   131 YKYIAELADARQDPFVIPVPFFNVLNGGAHAGGSLAMQEFKIAPVGAQSFAEAMRMGSEVYHHLK 195

  Fly   261 NVIKAKFGLDATAVGDEGGFAPNIQSNKEALNLISDAIAKAGYTGKIEIGMDVAASEFYKDGQYD 325
            .:.|.::|..|..||||||.||:|.:.::||::|..||...||.|::::|:|.|.|.|||||:||
Yeast   196 ILAKEQYGPSAGNVGDEGGVAPDIDTAEDALDMIVKAINICGYEGRVKVGIDSAPSVFYKDGKYD 260

  Fly   326 LDFKNEKSDKSQWLPADKLANLYQEFIKDFPIVSIEDPFDQDHWEAWSNLTGCTDIQIVGDDLTV 390
            |:||...||.|.||...:||..|...:|.:||:|:|||:.:|.|.:||......::||:.||||.
Yeast   261 LNFKEPNSDPSHWLSPAQLAEYYHSLLKKYPIISLEDPYAEDDWSSWSAFLKTVNVQIIADDLTC 325

  Fly   391 TNPKRIATAVEKKACNCLLLKVNQIGTVTESIAAHLLAKKNGWGTMVSHRSGETEDSFIGDLVVG 455
            ||..|||.|:|:|..|.||||:|||||:||||.|...|...|||.|:|||||||||.||.|||||
Yeast   326 TNKTRIARAIEEKCANTLLLKLNQIGTLTESIEAANQAFDAGWGVMISHRSGETEDPFIADLVVG 390

  Fly   456 LSTGQIKTGAPCRSERLAKYNQILRIEEEIGAGVKFAGKSF 496
            |..||||:||..|||||||||::||||||:|....:||..|
Yeast   391 LRCGQIKSGALSRSERLAKYNELLRIEEELGDDCIYAGHRF 431

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eno	NP_722721.1	PLN00191	69..499	CDD:215095	255/430 (59%)
Eno	NP_722721.1	enolase	72..484	CDD:239429	248/413 (60%)
ERR3	NP_014056.3	PTZ00081	1..428	CDD:240259	253/426 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344987
Domainoid	1	1.000	387	1.000	Domainoid score	I98
eggNOG	1	0.900	-	-		E1_COG0148
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H134343
Inparanoid	1	1.050	569	1.000	Inparanoid score	I154
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60632
OrthoFinder	1	1.000	-	-		FOG0000613
OrthoInspector	1	1.000	-	-		otm46864
orthoMCL	1	0.900	-	-		OOG6_100260
Panther	1	1.100	-	-	O	PTHR11902
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X347
TreeFam	1	0.960	-	-
	13	12.760