DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Eno and eno1b

DIOPT Version :9

Sequence 1:	NP_722721.1	Gene:	Eno / 33351	FlyBaseID:	FBgn0000579	Length:	500	Species:	Drosophila melanogaster
Sequence 2:	NP_956989.1	Gene:	eno1b / 393668	ZFINID:	ZDB-GENE-040426-1651	Length:	433	Species:	Danio rerio

Alignment Length:	432	Identity:	323/432 - (74%)
Similarity:	373/432 - (86%)	Gaps:	1/432 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 MTIKAIKARQIYDSRGNPTVEVDLTTELGLFRAAVPSGASTGVHEALELRDNDKANYHGKSVLKA 132
            |:|..|.||:|:||||||||||||.||.||||||||||||||::||||||||||:.|.||.|.||
Zfish     1 MSILKIHAREIFDSRGNPTVEVDLYTERGLFRAAVPSGASTGIYEALELRDNDKSRYLGKGVSKA 65

  Fly   133 VGHVNDTLGPELIKANLDVVDQASIDNFMIKLDGTENKSKFGANAILGVSLAVAKAGAAKKGVPL 197
            |.:||..:.|.||...:.||:|..||.||::||||||||:||||||||||||..|||||:|||||
Zfish    66 VENVNQHIAPALIGQGIPVVEQEKIDQFMLELDGTENKSRFGANAILGVSLAACKAGAAEKGVPL 130

  Fly   198 YKHIADLAGNKEIILPVPAFNVINGGSHAGNKLAMQEFMILPTGATSFTEAMKMGSEVYHHLKNV 262
            |:||||||||.|:|||||||||||||||||||||||||||||.||:||.|||::|:||||:||||
Zfish   131 YRHIADLAGNPEVILPVPAFNVINGGSHAGNKLAMQEFMILPVGASSFKEAMRIGAEVYHNLKNV 195

  Fly   263 IKAKFGLDATAVGDEGGFAPNIQSNKEALNLISDAIAKAGYTGKIEIGMDVAASEFYKDGQYDLD 327
            ||.|:|.|||.|||||||||||..|||||.|:.:||:|||||.::.|||||||||||:|||||||
Zfish   196 IKQKYGQDATNVGDEGGFAPNILENKEALELLKNAISKAGYTDEVVIGMDVAASEFYRDGQYDLD 260

  Fly   328 FKNEKSDKSQWLPADKLANLYQEFIKDFPIVSIEDPFDQDHWEAWSNLTGCTDIQIVGDDLTVTN 392
            ||: ..|..:::..|:||:||:.||:|:|:||||||||||.||||:|.|..|:||:|||||||||
Zfish   261 FKS-PDDPDRYISPDELADLYKSFIEDYPVVSIEDPFDQDDWEAWTNFTNSTEIQVVGDDLTVTN 324

  Fly   393 PKRIATAVEKKACNCLLLKVNQIGTVTESIAAHLLAKKNGWGTMVSHRSGETEDSFIGDLVVGLS 457
            |||||||||.:||||||||||||||||||:.|..:|:.:|||.|||||||||||:||.||||||.
Zfish   325 PKRIATAVENEACNCLLLKVNQIGTVTESLQACNMAQSSGWGVMVSHRSGETEDTFIADLVVGLC 389

  Fly   458 TGQIKTGAPCRSERLAKYNQILRIEEEIGAGVKFAGKSFRKP 499
            |||||||||||||||||||||||||||:|...:||||:||.|
Zfish   390 TGQIKTGAPCRSERLAKYNQILRIEEELGEKARFAGKNFRNP 431

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eno	NP_722721.1	PLN00191	69..499	CDD:215095	321/429 (75%)
Eno	NP_722721.1	enolase	72..484	CDD:239429	311/411 (76%)
eno1b	NP_956989.1	PLN00191	2..432	CDD:215095	322/431 (75%)
eno1b	NP_956989.1	enolase	5..416	CDD:239429	311/411 (76%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589172
Domainoid	1	1.000	454	1.000	Domainoid score	I483
eggNOG	1	0.900	-	-		E1_COG0148
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	653	1.000	Inparanoid score	I765
OMA	1	1.010	-	-		QHG60632
OrthoDB	1	1.010	-	-		D325232at33208
OrthoFinder	1	1.000	-	-		FOG0000613
OrthoInspector	1	1.000	-	-		otm25730
orthoMCL	1	0.900	-	-		OOG6_100260
Panther	1	1.100	-	-	LDO	PTHR11902
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R397
SonicParanoid	1	1.000	-	-		X347
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800