DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Eno and eno1a

DIOPT Version :9

Sequence 1:	NP_722721.1	Gene:	Eno / 33351	FlyBaseID:	FBgn0000579	Length:	500	Species:	Drosophila melanogaster
Sequence 2:	NP_997887.1	Gene:	eno1a / 334116	ZFINID:	ZDB-GENE-030131-6048	Length:	432	Species:	Danio rerio

Alignment Length:	432	Identity:	321/432 - (74%)
Similarity:	372/432 - (86%)	Gaps:	1/432 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 MTIKAIKARQIYDSRGNPTVEVDLTTELGLFRAAVPSGASTGVHEALELRDNDKANYHGKSVLKA 132
            |:|..|.||:|:||||||||||||.|:.||||||||||||||::||||||||||..|.||.|.||
Zfish     1 MSILKIHAREIFDSRGNPTVEVDLYTKKGLFRAAVPSGASTGIYEALELRDNDKTRYLGKGVSKA 65

  Fly   133 VGHVNDTLGPELIKANLDVVDQASIDNFMIKLDGTENKSKFGANAILGVSLAVAKAGAAKKGVPL 197
            |.|:|.|:.|.|:..|:.|::|..||..|:.:|||:|||||||||||||||||.|||||:|||||
Zfish    66 VEHINKTIAPGLVSQNVSVLEQEKIDKLMLDMDGTDNKSKFGANAILGVSLAVCKAGAAEKGVPL 130

  Fly   198 YKHIADLAGNKEIILPVPAFNVINGGSHAGNKLAMQEFMILPTGATSFTEAMKMGSEVYHHLKNV 262
            |:||||||||.::|||||||||||||||||||||||||||||.||::|.|||::|:||||:||||
Zfish   131 YRHIADLAGNPDVILPVPAFNVINGGSHAGNKLAMQEFMILPVGASNFKEAMRIGAEVYHNLKNV 195

  Fly   263 IKAKFGLDATAVGDEGGFAPNIQSNKEALNLISDAIAKAGYTGKIEIGMDVAASEFYKDGQYDLD 327
            ||.|:|.|||.|||||||||||..|||||.|:.:||:|||||.||.||||||||||||.|:||||
Zfish   196 IKEKYGKDATNVGDEGGFAPNILENKEALELLKNAISKAGYTDKIVIGMDVAASEFYKGGKYDLD 260

  Fly   328 FKNEKSDKSQWLPADKLANLYQEFIKDFPIVSIEDPFDQDHWEAWSNLTGCTDIQIVGDDLTVTN 392
            ||: ..|.|:::..||||:||:.|:||:|:||||||||||.||||:|.|..|:||:|||||||||
Zfish   261 FKS-PDDPSRYISPDKLADLYKSFVKDYPVVSIEDPFDQDDWEAWTNFTATTNIQVVGDDLTVTN 324

  Fly   393 PKRIATAVEKKACNCLLLKVNQIGTVTESIAAHLLAKKNGWGTMVSHRSGETEDSFIGDLVVGLS 457
            |||||.||..||||||||||||||:||||:.|..:|:.||||.|||||||||||:||.||||||.
Zfish   325 PKRIAKAVSDKACNCLLLKVNQIGSVTESLQACKMAQTNGWGVMVSHRSGETEDTFIADLVVGLC 389

  Fly   458 TGQIKTGAPCRSERLAKYNQILRIEEEIGAGVKFAGKSFRKP 499
            ||||||||||||||||||||:||||||:|...:||||:||||
Zfish   390 TGQIKTGAPCRSERLAKYNQLLRIEEELGDKARFAGKNFRKP 431

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eno	NP_722721.1	PLN00191	69..499	CDD:215095	318/429 (74%)
Eno	NP_722721.1	enolase	72..484	CDD:239429	308/411 (75%)
eno1a	NP_997887.1	PLN00191	2..431	CDD:215095	318/429 (74%)
eno1a	NP_997887.1	enolase	5..416	CDD:239429	308/411 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589174
Domainoid	1	1.000	454	1.000	Domainoid score	I483
eggNOG	1	0.900	-	-		E1_COG0148
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H134343
Inparanoid	1	1.050	653	1.000	Inparanoid score	I765
OMA	1	1.010	-	-		QHG60632
OrthoDB	1	1.010	-	-		D325232at33208
OrthoFinder	1	1.000	-	-		FOG0000613
OrthoInspector	1	1.000	-	-		otm25730
orthoMCL	1	0.900	-	-		OOG6_100260
Panther	1	1.100	-	-	O	PTHR11902
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X347
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.770