DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eno and Eno4

DIOPT Version :9

Sequence 1:	NP_722721.1	Gene:	Eno / 33351	FlyBaseID:	FBgn0000579	Length:	500	Species:	Drosophila melanogaster
Sequence 2:	XP_006231731.1	Gene:	Eno4 / 292138	RGDID:	1308333	Length:	614	Species:	Rattus norvegicus

Alignment Length:	527	Identity:	137/527 - (25%)
Similarity:	214/527 - (40%)	Gaps:	137/527 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 TIKAIKARQIYDSRGNPTVEVDLTTELGLF-----RAAVPSGASTGVHEAL-ELRDNDKANYHGK 127
            :|..|..:.|.|..|.||::|:::..:..|     ..|:|:.:.. |..|| |:.|.|:|. ..:
  Rat    67 SICKIVGKTILDGLGLPTLQVEISCTIQNFPKYICSVAIPTHSEV-VENALPEMVDADEAE-RQQ 129

  Fly   128 SVLKAVGHVNDTLGPE---LIKANLDVVD-----------QASIDNFMIKLDGTE---------- 168
            :|.|||..:|..:..|   ||.:|...||           ||..|...::....|
  Rat   130 AVSKAVRWINQFITEELWGLIPSNQAEVDRRLRIFFEHKVQADKDRKELERSQEEPVPMTLPVIL 194

  Fly   169 -------NKSK-------------------------FGANAILGVSLAVAKAGAAKKGVPLYKHI 201
                   :|.|                         .|:.||..|||||||..|...|.|||..:
  Rat   195 PPPPPPPSKKKGQKAGRRDTLLEKPIFPPEPPEPVLHGSMAIGAVSLAVAKTSATLAGTPLYLTL 259

  Fly   202 ADLAGNKE----IILPVPAFNVINGGSHAGNKL-AMQEFMILPT-GATSFTEAMKMGSEVYHHL- 259
            |.|..::|    ..:|:...:|::.|..:..|| .|:|.|.:|: |.|:     |.|.|:...:
  Rat   260 ALLKHDQEQPSTFSMPLLMGSVLSCGKSSPGKLHLMKEVMCIPSPGLTT-----KQGIELLLEIQ 319

  Fly   260 KNVIKAKFGL----DATAVGDEGG----------------FAPNIQSNKEALNLISDAIAKAGYT 304
            |.|.:|...|    ..|..|..||                ...|..:.::.|.||....:..|
  Rat   320 KQVNRAMETLPPPKPETKKGHNGGKRSQPPITGRASHLGCLTINYDTIEQPLLLIQGICSNLG-- 382

  Fly   305 GKIEIG------MDVAASEF--YKDGQYDLDFKNEKSDKSQWLPADKLANLYQEFIKDFP-IVSI 360
              :|:|      ::.|..|.  |..|:|::.....||       |.::..||.:.|..:| |:::
  Rat   383 --LELGVNFHLAINCAGHELMDYSKGKYEVMVGTYKS-------AAEMVELYVDLINKYPSIIAL 438

  Fly   361 EDPFDQDHWEAWSNLTGCTDIQ---IVGDDLTVTNPKRIATAVEKKACNCLLLK--------VNQ 414
            .|||.::..|.|.:|......:   |.|     ...:.::..:|.:  |..|||        .||
  Rat   439 IDPFRKEDSEQWDSLYAAVASRCYLIAG-----AASRSVSRLLEDR--NISLLKYHGLIIKHTNQ 496

  Fly   415 IGTVTESI-AAHLLAKKNGWGTMVSHRSGETEDSFIGDLVVGLSTGQIKTGAPCRSERLAKYNQI 478
            . |:::.: ..||:..|.......|..|..::||.: ||.|||....||.|...|.||:.|||::
  Rat   497 T-TMSDLVEITHLINGKKHLAVFGSTDSESSDDSLV-DLAVGLGARFIKLGGLSRGERMTKYNRL 559

  Fly   479 LRIEEEI 485
            |.||||:
  Rat   560 LAIEEEL 566

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eno	NP_722721.1	PLN00191	69..499	CDD:215095	137/527 (26%)
Eno	NP_722721.1	enolase	72..484	CDD:239429	134/521 (26%)
Eno4	XP_006231731.1	eno	68..566	CDD:213580	136/524 (26%)
Eno4	XP_006231731.1	TIM_phosphate_binding	70..565	CDD:304361	134/521 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347644
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0148
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11902
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840