DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Eno and Eno3

DIOPT Version :9

Sequence 1:	NP_722721.1	Gene:	Eno / 33351	FlyBaseID:	FBgn0000579	Length:	500	Species:	Drosophila melanogaster
Sequence 2:	NP_037081.2	Gene:	Eno3 / 25438	RGDID:	2555	Length:	434	Species:	Rattus norvegicus

Alignment Length:	433	Identity:	316/433 - (72%)
Similarity:	361/433 - (83%)	Gaps:	1/433 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 MTIKAIKARQIYDSRGNPTVEVDLTTELGLFRAAVPSGASTGVHEALELRDNDKANYHGKSVLKA 132
            |.::.|.||:|.||||||||||||.|..|.||||||||||||::|||||||.||:.|.||.||||
  Rat     1 MAMQKIFAREILDSRGNPTVEVDLHTAKGRFRAAVPSGASTGIYEALELRDGDKSRYLGKGVLKA 65

  Fly   133 VGHVNDTLGPELIKANLDVVDQASIDNFMIKLDGTENKSKFGANAILGVSLAVAKAGAAKKGVPL 197
            |.|:|.||||.|::..|.||||..:|.|||:||||||||||||||||||||||.|||||:|||||
  Rat    66 VEHINKTLGPALLEKKLSVVDQEKVDKFMIELDGTENKSKFGANAILGVSLAVCKAGAAEKGVPL 130

  Fly   198 YKHIADLAGNKEIILPVPAFNVINGGSHAGNKLAMQEFMILPTGATSFTEAMKMGSEVYHHLKNV 262
            |:||||||||.:::||||||||||||||||||||||||||||.||:||.|||::|:|||||||.|
  Rat   131 YRHIADLAGNPDLVLPVPAFNVINGGSHAGNKLAMQEFMILPVGASSFKEAMRIGAEVYHHLKGV 195

  Fly   263 IKAKFGLDATAVGDEGGFAPNIQSNKEALNLISDAIAKAGYTGKIEIGMDVAASEFYKDGQYDLD 327
            ||||:|.|||.|||||||||||..|.|||.|:..||..|||..|:.|||||||||||::|:||||
  Rat   196 IKAKYGKDATNVGDEGGFAPNILENNEALELLKTAIQAAGYPDKVVIGMDVAASEFYRNGKYDLD 260

  Fly   328 FKNEKSDKSQWLPADKLANLYQEFIKDFPIVSIEDPFDQDHWEAWSNLTGCTDIQIVGDDLTVTN 392
            ||: ..|.::.:..:||..||:.|||::|:||||||||||.|..|::.....|||||||||||||
  Rat   261 FKS-PDDPARHISGEKLGELYKSFIKNYPVVSIEDPFDQDDWATWTSFLSGVDIQIVGDDLTVTN 324

  Fly   393 PKRIATAVEKKACNCLLLKVNQIGTVTESIAAHLLAKKNGWGTMVSHRSGETEDSFIGDLVVGLS 457
            |||||.||||||||||||||||||:|||||.|..||:.||||.|||||||||||:||.||||||.
  Rat   325 PKRIAQAVEKKACNCLLLKVNQIGSVTESIQACKLAQSNGWGVMVSHRSGETEDTFIADLVVGLC 389

  Fly   458 TGQIKTGAPCRSERLAKYNQILRIEEEIGAGVKFAGKSFRKPQ 500
            ||||||||||||||||||||::||||.:|....|||:.||.|:
  Rat   390 TGQIKTGAPCRSERLAKYNQLMRIEEALGDKAVFAGRKFRNPK 432

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eno	NP_722721.1	PLN00191	69..499	CDD:215095	314/429 (73%)
Eno	NP_722721.1	enolase	72..484	CDD:239429	307/411 (75%)
Eno3	NP_037081.2	PLN00191	2..431	CDD:215095	314/429 (73%)
		enolase	5..415	CDD:239429	306/410 (75%)
		Substrate binding. /evidence=ECO:0000250	370..373		2/2 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347643
Domainoid	1	1.000	442	1.000	Domainoid score	I516
eggNOG	1	0.900	-	-		E1_COG0148
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	644	1.000	Inparanoid score	I775
OMA	1	1.010	-	-		QHG60632
OrthoDB	1	1.010	-	-		D325232at33208
OrthoFinder	1	1.000	-	-		FOG0000613
OrthoInspector	1	1.000	-	-		otm45816
orthoMCL	1	0.900	-	-		OOG6_100260
Panther	1	1.100	-	-	O	PTHR11902
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X347
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.770