DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eno and Eno1

DIOPT Version :9

Sequence 1:	NP_722721.1	Gene:	Eno / 33351	FlyBaseID:	FBgn0000579	Length:	500	Species:	Drosophila melanogaster
Sequence 2:	NP_001103378.1	Gene:	Eno1 / 24333	RGDID:	2553	Length:	434	Species:	Rattus norvegicus

Alignment Length:	432	Identity:	319/432 - (73%)
Similarity:	366/432 - (84%)	Gaps:	1/432 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 MTIKAIKARQIYDSRGNPTVEVDLTTELGLFRAAVPSGASTGVHEALELRDNDKANYHGKSVLKA 132
            |:|..|.||:|:||||||||||||.|..||||||||||||||::||||||||||..:.||.|.||
  Rat     1 MSILKIHAREIFDSRGNPTVEVDLYTAKGLFRAAVPSGASTGIYEALELRDNDKTRFMGKGVSKA 65

  Fly   133 VGHVNDTLGPELIKANLDVVDQASIDNFMIKLDGTENKSKFGANAILGVSLAVAKAGAAKKGVPL 197
            |.|:|.|:.|.|:...|:||:|..||..||::|||||||||||||||||||||.||||.:|||||
  Rat    66 VEHINKTIAPALVSKKLNVVEQEKIDQLMIEMDGTENKSKFGANAILGVSLAVCKAGAVEKGVPL 130

  Fly   198 YKHIADLAGNKEIILPVPAFNVINGGSHAGNKLAMQEFMILPTGATSFTEAMKMGSEVYHHLKNV 262
            |:||||||||.|:|||||||||||||||||||||||||||||.||:||.|||::|:||||:||||
  Rat   131 YRHIADLAGNPEVILPVPAFNVINGGSHAGNKLAMQEFMILPVGASSFREAMRIGAEVYHNLKNV 195

  Fly   263 IKAKFGLDATAVGDEGGFAPNIQSNKEALNLISDAIAKAGYTGKIEIGMDVAASEFYKDGQYDLD 327
            ||.|:|.|||.|||||||||||..|||||.|:..||||||||.::.|||||||||||:.|:||||
  Rat   196 IKEKYGKDATNVGDEGGFAPNILENKEALELLKSAIAKAGYTDQVVIGMDVAASEFYRAGKYDLD 260

  Fly   328 FKNEKSDKSQWLPADKLANLYQEFIKDFPIVSIEDPFDQDHWEAWSNLTGCTDIQIVGDDLTVTN 392
            ||: ..|.|:::..|:||:||:.||||:|:||||||||||.|:||...|....||:|||||||||
  Rat   261 FKS-PDDASRYITPDQLADLYKSFIKDYPVVSIEDPFDQDDWDAWQKFTATAGIQVVGDDLTVTN 324

  Fly   393 PKRIATAVEKKACNCLLLKVNQIGTVTESIAAHLLAKKNGWGTMVSHRSGETEDSFIGDLVVGLS 457
            |||||.|..:|:||||||||||||:||||:.|..||:.||||.|||||||||||:||.||||||.
  Rat   325 PKRIAKAAGEKSCNCLLLKVNQIGSVTESLQACKLAQSNGWGVMVSHRSGETEDTFIADLVVGLC 389

  Fly   458 TGQIKTGAPCRSERLAKYNQILRIEEEIGAGVKFAGKSFRKP 499
            |||||||||||||||||||||||||||:|:..||||:|||.|
  Rat   390 TGQIKTGAPCRSERLAKYNQILRIEEELGSKAKFAGRSFRNP 431

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eno	NP_722721.1	PLN00191	69..499	CDD:215095	317/429 (74%)
Eno	NP_722721.1	enolase	72..484	CDD:239429	306/411 (74%)
Eno1	NP_001103378.1	PLN00191	2..432	CDD:215095	318/431 (74%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:P00924	370..373		2/2 (100%)
		Required for interaction with PLG. /evidence=ECO:0000269\|PubMed:7964722	405..434		21/27 (78%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347647
Domainoid	1	1.000	442	1.000	Domainoid score	I516
eggNOG	1	0.900	-	-		E1_COG0148
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H134343
Inparanoid	1	1.050	644	1.000	Inparanoid score	I775
OMA	1	1.010	-	-		QHG60632
OrthoDB	1	1.010	-	-		D325232at33208
OrthoFinder	1	1.000	-	-		FOG0000613
OrthoInspector	1	1.000	-	-		otm45816
orthoMCL	1	0.900	-	-		OOG6_100260
Panther	1	1.100	-	-	O	PTHR11902
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X347
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770