DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Eno and Eno3

DIOPT Version :9

Sequence 1:	NP_722721.1	Gene:	Eno / 33351	FlyBaseID:	FBgn0000579	Length:	500	Species:	Drosophila melanogaster
Sequence 2:	XP_006532224.1	Gene:	Eno3 / 13808	MGIID:	95395	Length:	520	Species:	Mus musculus

Alignment Length:	433	Identity:	316/433 - (72%)
Similarity:	361/433 - (83%)	Gaps:	1/433 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 MTIKAIKARQIYDSRGNPTVEVDLTTELGLFRAAVPSGASTGVHEALELRDNDKANYHGKSVLKA 132
            |.::.|.||:|.||||||||||||.|..|.||||||||||||::|||||||.|||.|.||.||||
Mouse    87 MAMQKIFAREILDSRGNPTVEVDLHTAKGRFRAAVPSGASTGIYEALELRDGDKARYLGKGVLKA 151

  Fly   133 VGHVNDTLGPELIKANLDVVDQASIDNFMIKLDGTENKSKFGANAILGVSLAVAKAGAAKKGVPL 197
            |.|:|.||||.|::..|.||||..:|.|||:||||||||||||||||||||||.|||||:|||||
Mouse   152 VEHINKTLGPALLEKKLSVVDQEKVDKFMIELDGTENKSKFGANAILGVSLAVCKAGAAEKGVPL 216

  Fly   198 YKHIADLAGNKEIILPVPAFNVINGGSHAGNKLAMQEFMILPTGATSFTEAMKMGSEVYHHLKNV 262
            |:||||||||.:::||||||||||||||||||||||||||||.||:||.|||::|:|||||||.|
Mouse   217 YRHIADLAGNPDLVLPVPAFNVINGGSHAGNKLAMQEFMILPVGASSFKEAMRIGAEVYHHLKGV 281

  Fly   263 IKAKFGLDATAVGDEGGFAPNIQSNKEALNLISDAIAKAGYTGKIEIGMDVAASEFYKDGQYDLD 327
            ||||:|.|||.|||||||||||..|.|||.|:..||..|||..|:.|||||||||||::|:||||
Mouse   282 IKAKYGKDATNVGDEGGFAPNILENNEALELLKTAIQAAGYPDKVVIGMDVAASEFYRNGKYDLD 346

  Fly   328 FKNEKSDKSQWLPADKLANLYQEFIKDFPIVSIEDPFDQDHWEAWSNLTGCTDIQIVGDDLTVTN 392
            ||: ..|.::.:..:||..||:.||:::|:||||||||||.|..|::.....|||||||||||||
Mouse   347 FKS-PDDPARHISGEKLGELYKNFIQNYPVVSIEDPFDQDDWATWTSFLSGVDIQIVGDDLTVTN 410

  Fly   393 PKRIATAVEKKACNCLLLKVNQIGTVTESIAAHLLAKKNGWGTMVSHRSGETEDSFIGDLVVGLS 457
            |||||.||||||||||||||||||:|||||.|..||:.||||.|||||||||||:||.||||||.
Mouse   411 PKRIAQAVEKKACNCLLLKVNQIGSVTESIQACKLAQSNGWGVMVSHRSGETEDTFIADLVVGLC 475

  Fly   458 TGQIKTGAPCRSERLAKYNQILRIEEEIGAGVKFAGKSFRKPQ 500
            ||||||||||||||||||||::||||.:|....|||:.||.|:
Mouse   476 TGQIKTGAPCRSERLAKYNQLMRIEEALGDKAVFAGRKFRNPK 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eno	NP_722721.1	PLN00191	69..499	CDD:215095	314/429 (73%)
Eno	NP_722721.1	enolase	72..484	CDD:239429	307/411 (75%)
Eno3	XP_006532224.1	PLN00191	63..517	CDD:215095	315/430 (73%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844284
Domainoid	1	1.000	438	1.000	Domainoid score	I555
eggNOG	1	0.900	-	-		E1_COG0148
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	637	1.000	Inparanoid score	I826
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60632
OrthoDB	1	1.010	-	-		D325232at33208
OrthoFinder	1	1.000	-	-		FOG0000613
OrthoInspector	1	1.000	-	-		otm43739
orthoMCL	1	0.900	-	-		OOG6_100260
Panther	1	1.100	-	-	O	PTHR11902
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R397
SonicParanoid	1	1.000	-	-		X347
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.800