DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eno and Eno2

DIOPT Version :9

Sequence 1:	NP_722721.1	Gene:	Eno / 33351	FlyBaseID:	FBgn0000579	Length:	500	Species:	Drosophila melanogaster
Sequence 2:	NP_001342149.1	Gene:	Eno2 / 13807	MGIID:	95394	Length:	434	Species:	Mus musculus

Alignment Length:	432	Identity:	310/432 - (71%)
Similarity:	362/432 - (83%)	Gaps:	1/432 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 MTIKAIKARQIYDSRGNPTVEVDLTTELGLFRAAVPSGASTGVHEALELRDNDKANYHGKSVLKA 132
            |:|:.|.||:|.||||||||||||.|..||||||||||||||::|||||||.||..|.||.||||
Mouse     1 MSIEKIWAREILDSRGNPTVEVDLYTAKGLFRAAVPSGASTGIYEALELRDGDKQRYLGKGVLKA 65

  Fly   133 VGHVNDTLGPELIKANLDVVDQASIDNFMIKLDGTENKSKFGANAILGVSLAVAKAGAAKKGVPL 197
            |.|:|..:.|.||.:.:.||:|..:||.|::||||||||||||||||||||||.|||||::.:||
Mouse    66 VDHINSRIAPALISSGISVVEQEKLDNLMLELDGTENKSKFGANAILGVSLAVCKAGAAERDLPL 130

  Fly   198 YKHIADLAGNKEIILPVPAFNVINGGSHAGNKLAMQEFMILPTGATSFTEAMKMGSEVYHHLKNV 262
            |:|||.||||.::|||||||||||||||||||||||||||||.||.||.:||::|:||||.||.|
Mouse   131 YRHIAQLAGNSDLILPVPAFNVINGGSHAGNKLAMQEFMILPVGAESFRDAMRLGAEVYHTLKGV 195

  Fly   263 IKAKFGLDATAVGDEGGFAPNIQSNKEALNLISDAIAKAGYTGKIEIGMDVAASEFYKDGQYDLD 327
            ||.|:|.|||.|||||||||||..|.|||.|:.:||.|||||.|:.|||||||||||:||:||||
Mouse   196 IKDKYGKDATNVGDEGGFAPNILENSEALELVKEAIDKAGYTEKMVIGMDVAASEFYRDGKYDLD 260

  Fly   328 FKNEKSDKSQWLPADKLANLYQEFIKDFPIVSIEDPFDQDHWEAWSNLTGCTDIQIVGDDLTVTN 392
            ||: .:|.|:::..|:|..|||:|::::|:||||||||||.|.|||..|....||||||||||||
Mouse   261 FKS-PADPSRYITGDQLGALYQDFVRNYPVVSIEDPFDQDDWAAWSKFTANVGIQIVGDDLTVTN 324

  Fly   393 PKRIATAVEKKACNCLLLKVNQIGTVTESIAAHLLAKKNGWGTMVSHRSGETEDSFIGDLVVGLS 457
            ||||..|||:||||||||||||||:|||:|.|..||::||||.|||||||||||:||.||||||.
Mouse   325 PKRIERAVEEKACNCLLLKVNQIGSVTEAIQACKLAQENGWGVMVSHRSGETEDTFIADLVVGLC 389

  Fly   458 TGQIKTGAPCRSERLAKYNQILRIEEEIGAGVKFAGKSFRKP 499
            ||||||||||||||||||||::|||||:|...:|||.:||.|
Mouse   390 TGQIKTGAPCRSERLAKYNQLMRIEEELGDEARFAGHNFRNP 431

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eno	NP_722721.1	PLN00191	69..499	CDD:215095	308/429 (72%)
Eno	NP_722721.1	enolase	72..484	CDD:239429	299/411 (73%)
Eno2	NP_001342149.1	PLN00191	2..432	CDD:215095	309/431 (72%)
Eno2	NP_001342149.1	Substrate binding. /evidence=ECO:0000250\|UniProtKB:P00924	370..373		2/2 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844281
Domainoid	1	1.000	438	1.000	Domainoid score	I555
eggNOG	1	0.900	-	-		E1_COG0148
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	637	1.000	Inparanoid score	I826
Isobase	1	0.950	-	0	Normalized mean entropy	S167
OMA	1	1.010	-	-		QHG60632
OrthoDB	1	1.010	-	-		D325232at33208
OrthoFinder	1	1.000	-	-		FOG0000613
OrthoInspector	1	1.000	-	-		otm43739
orthoMCL	1	0.900	-	-		OOG6_100260
Panther	1	1.100	-	-	O	PTHR11902
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R397
SonicParanoid	1	1.000	-	-		X347
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.750