DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rim2 and SLC25A36

DIOPT Version :9

Sequence 1:	NP_608615.1	Gene:	Rim2 / 33350	FlyBaseID:	FBgn0031359	Length:	365	Species:	Drosophila melanogaster
Sequence 2:	NP_001098117.1	Gene:	SLC25A36 / 55186	HGNCID:	25554	Length:	311	Species:	Homo sapiens

Alignment Length:	358	Identity:	177/358 - (49%)
Similarity:	220/358 - (61%)	Gaps:	56/358 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAQNTADTLIHLIAGGSAGTVGAVVTCPLEVVKTRLQSSTAFMTPSRLAENAGGGPANGGQSELL 65
            |:|.  |||:||.|||..|||||::||||||||||||||:..:..|.:..|...|
Human     1 MSQR--DTLVHLFAGGCGGTVGAILTCPLEVVKTRLQSSSVTLYISEVQLNTMAG---------- 53

  Fly    66 RPEQRRKLSTTILRNRSQPQVIGGVRRIMAISHCGISSTTPKSMSIVQCLRHIVQNEGPRALFKG 130
                                  ..|.|::             |...:.||:.|::.||||:||:|
Human    54 ----------------------ASVNRVV-------------SPGPLHCLKVILEKEGPRSLFRG 83

  Fly   131 LGPNLVGVAPSRAIYFCTYSQTKNTLNSLGFVERDSPLVHIMSAASAGFVSSTATNPIWFVKTRM 195
            ||||||||||||||||..||..|..||.:  .:.||..||::|||.|||.:.|||||||.:|||:
Human    84 LGPNLVGVAPSRAIYFAAYSNCKEKLNDV--FDPDSTQVHMISAAMAGFTAITATNPIWLIKTRL 146

  Fly   196 QLDYNSKVQ--MTVRQCIERVYAQGGVAAFYKGITASYFGICETMVHFVIYEFIKSKLLEQR--- 255
            |||..::.:  |...:|:.:||...|:..||:|::|||.||.||::||||||.||.||||.:
Human   147 QLDARNRGERRMGAFECVRKVYQTDGLKGFYRGMSASYAGISETVIHFVIYESIKQKLLEYKTAS 211

  Fly   256 --NQRHTDTKGSRDFLEFMMAGAVSKTIASCIAYPHEVARTRLREEGNKYNSFWQTLHTVWKEEG 318
              .......|.:.||:..|:|.|.|||.|:.|||||||.||||||||.||.||:|||..:.:|||
Human   212 TMENDEESVKEASDFVGMMLAAATSKTCATTIAYPHEVVRTRLREEGTKYRSFFQTLSLLVQEEG 276

  Fly   319 RAGLYRGLATQLVRQIPNTAIMMATYEAVVYVL 351
            ...|||||.|.||||||||||||||||.|||:|
Human   277 YGSLYRGLTTHLVRQIPNTAIMMATYELVVYLL 309

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rim2	NP_608615.1	Mito_carr	8..156	CDD:278578	61/147 (41%)
		Mito_carr	163..253	CDD:278578	48/91 (53%)
		Mito_carr	268..355	CDD:278578	59/84 (70%)
SLC25A36	NP_001098117.1	Solcar 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00282	4..108		62/150 (41%)
		Mito_carr	6..111	CDD:365909	62/149 (42%)
		Solcar 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00282	116..203		46/86 (53%)
		Mito_carr	117..206	CDD:365909	47/88 (53%)
		Solcar 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00282	224..308		58/83 (70%)
		Mito_carr	226..311	CDD:365909	59/84 (70%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	118	1.000	Domainoid score	I5854
eggNOG	1	0.900	-	-		E1_COG4266
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10039
Inparanoid	1	1.050	310	1.000	Inparanoid score	I2604
Isobase	1	0.950	-	0	Normalized mean entropy	S1076
OMA	1	1.010	-	-		QHG53601
OrthoDB	1	1.010	-	-		D1372287at2759
OrthoFinder	1	1.000	-	-		FOG0002320
OrthoInspector	1	1.000	-	-		otm40440
orthoMCL	1	0.900	-	-		OOG6_103444
Panther	1	1.100	-	-	O	PTHR45829
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1930
SonicParanoid	1	1.000	-	-		X1747
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.820