DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rim2 and Slc25a17

DIOPT Version :9

Sequence 1:	NP_608615.1	Gene:	Rim2 / 33350	FlyBaseID:	FBgn0031359	Length:	365	Species:	Drosophila melanogaster
Sequence 2:	NP_035529.1	Gene:	Slc25a17 / 20524	MGIID:	1342248	Length:	307	Species:	Mus musculus

Alignment Length:	361	Identity:	81/361 - (22%)
Similarity:	138/361 - (38%)	Gaps:	101/361 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 DTLIHLIAGGSAGTVGAVVTCPLEVVKTRLQSSTAFMTPSRLAENAGGGPANGGQSELLRPEQRR 71
            ::|:|.:||.........|..||:..:.|||                             .:::|
Mouse     8 ESLVHAVAGAVGSVTAMTVFFPLDTARLRLQ-----------------------------VDEKR 43

  Fly    72 KLSTTILRNRSQPQVIGGVRRIMAISHCGISSTTPKSMSIVQCLRHIVQNEGPRALFKGLGPNLV 136
            |..||                     |.              .|..|::.||..|.::|..|.:.
Mouse    44 KSKTT---------------------HA--------------VLLEIIKEEGLLAPYRGWFPVIS 73

  Fly   137 GVAPSRAIYFCTYSQTKNTLNSLGFV----ERDSPLVHIMSAASAGFVSSTATNPIWFVKTRMQL 197
            .:..|..:||.|:       |||..|    :|.|....::....||.|:...|.|:|.|.||::|
Mouse    74 SLCCSNFVYFYTF-------NSLKAVWVKGQRSSTGKDLVVGFVAGVVNVLLTTPLWVVNTRLKL 131

  Fly   198 D----YNSKVQMT----VRQCIERVYAQGGVAAFYKGITASYFGICETMVHFVIYEFIKSKLLEQ 254
            .    .|..:..|    :.....::....|:.|.:.|...|...:....:.|:.||.:|.:||::
Mouse   132 QGAKFRNEDIIPTNYKGIIDAFHQIIRDEGILALWNGTFPSLLLVFNPAIQFMFYEGLKRQLLKK 196

  Fly   255 RNQRHTDTKGSRDFLEFMMAGAVSKTIASCIAYPHEVARTRLREEGNKYNSFWQT---------- 309
            |.:..:        |:..:.||::|.||:.:.||.:..::.||...::.|...:|
Mouse   197 RMKLSS--------LDVFIIGAIAKAIATTVTYPMQTVQSILRFGRHRLNPENRTLGSLRNVLSL 253

  Fly   310 LHTVWKEEGRAGLYRGLATQLVRQIPNTAIMMATYE 345
            ||...|..|..|||:||..:|::.:...|:|...||
Mouse   254 LHQRVKRFGIMGLYKGLEAKLLQTVLTAALMFLVYE 289

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rim2	NP_608615.1	Mito_carr	8..156	CDD:278578	26/147 (18%)
		Mito_carr	163..253	CDD:278578	23/97 (24%)
		Mito_carr	268..355	CDD:278578	26/88 (30%)
Slc25a17	NP_035529.1	Necessary for targeting to peroxisomes and interaction with PEX19. /evidence=ECO:0000250	1..147		44/209 (21%)
		Mito_carr	10..95	CDD:365909	30/155 (19%)
		Solcar 2	99..192		21/92 (23%)
		Mito_carr	100..195	CDD:365909	22/94 (23%)
		Peroxisome localization signal. /evidence=ECO:0000250	190..199		4/8 (50%)
		Solcar 3	200..294		26/98 (27%)
		Mito_carr	217..291	CDD:365909	20/73 (27%)
		Necessary for targeting to peroxisomes and interaction with PEX19. /evidence=ECO:0000250	244..307		14/46 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4266
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53601
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820