DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rim2 and SLC25A17

DIOPT Version :9

Sequence 1:	NP_608615.1	Gene:	Rim2 / 33350	FlyBaseID:	FBgn0031359	Length:	365	Species:	Drosophila melanogaster
Sequence 2:	NP_006349.1	Gene:	SLC25A17 / 10478	HGNCID:	10987	Length:	307	Species:	Homo sapiens

Alignment Length:	372	Identity:	80/372 - (21%)
Similarity:	138/372 - (37%)	Gaps:	123/372 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 DTLIHLIAGGSAGTVGAVVTCPLEVVKTRLQSSTAFMTPSRLAENAGGGPANGGQSELLRPEQRR 71
            ::|:|.:||.........|..||:..:.|||                             .:::|
Human     8 ESLVHAVAGAVGSVTAMTVFFPLDTARLRLQ-----------------------------VDEKR 43

  Fly    72 KLSTTILRNRSQPQVIGGVRRIMAISHCGISSTTPKSMSIVQCLRHIVQNEGPRALFKGLGPNLV 136
            |..||.:                                   .|..|::.||..|.::|..|.:.
Human    44 KSKTTHM-----------------------------------VLLEIIKEEGLLAPYRGWFPVIS 73

  Fly   137 GVAPSRAIYFCTYSQTKNTLNSL---------------GFVERDSPLVHIMSAASAGFVSSTATN 186
            .:..|..:||.|:    |:|.:|               |||              ||.|:...|.
Human    74 SLCCSNFVYFYTF----NSLKALWVKGQHSTTGKDLVVGFV--------------AGVVNVLLTT 120

  Fly   187 PIWFVKTRMQLD----YNSKVQMT----VRQCIERVYAQGGVAAFYKGITASYFGICETMVHFVI 243
            |:|.|.||::|.    .|..:..|    :.....::....|::|.:.|...|...:....:.|:.
Human   121 PLWVVNTRLKLQGAKFRNEDIVPTNYKGIIDAFHQIIRDEGISALWNGTFPSLLLVFNPAIQFMF 185

  Fly   244 YEFIKSKLLEQRNQRHTDTKGSRDFLEFMMAGAVSKTIASCIAYPHEVARTRLREEGNKYNSFWQ 308
            ||.:|.:||::|.:..:        |:..:.|||:|.||:.:.||.:..::.||...::.|...:
Human   186 YEGLKRQLLKKRMKLSS--------LDVFIIGAVAKAIATTVTYPLQTVQSILRFGRHRLNPENR 242

  Fly   309 T----------LHTVWKEEGRAGLYRGLATQLVRQIPNTAIMMATYE 345
            |          ||...:..|..|||:||..:|::.:...|:|...||
Human   243 TLGSLRNILYLLHQRVRRFGIMGLYKGLEAKLLQTVLTAALMFLVYE 289

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rim2	NP_608615.1	Mito_carr	8..156	CDD:278578	26/147 (18%)
		Mito_carr	163..253	CDD:278578	21/97 (22%)
		Mito_carr	268..355	CDD:278578	26/88 (30%)
SLC25A17	NP_006349.1	Necessary for targeting to peroxisomes and interaction with PEX19	1..147		43/220 (20%)
		Mito_carr	10..95	CDD:278578	28/152 (18%)
		Mito_carr	97..197	CDD:278578	25/113 (22%)
		Solcar 2	99..192		23/106 (22%)
		Peroxisome localization signal	190..199		4/8 (50%)
		Mito_carr	199..291	CDD:278578	26/99 (26%)
		Solcar 3	200..294		26/98 (27%)
		Necessary for targeting to peroxisomes and interaction with PEX19	244..307		13/46 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4266
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53601
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820