DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment frtz and wdpcp

DIOPT Version :9

Sequence 1:	NP_001259879.1	Gene:	frtz / 33349	FlyBaseID:	FBgn0086698	Length:	951	Species:	Drosophila melanogaster
Sequence 2:	XP_005158592.1	Gene:	wdpcp / 100333125	ZFINID:	ZDB-GENE-100405-4	Length:	707	Species:	Danio rerio

Alignment Length:	739	Identity:	180/739 - (24%)
Similarity:	318/739 - (43%)	Gaps:	101/739 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LSETHFWTTLREDVVRIKSQDLGAFRYLRQRDKEQEQQDLACLAKRDYTERRNGLAVLKNSGRKS 67
            |:|.|.|:.  .:.:::..:|:|.::...:.:............|:.:.:.|.....|.|   :.
Zfish     5 LAELHLWSF--RNSLQVPDRDIGTYQLYEKGEPASPTDQHYYNEKQQFADSRGYPWFLSN---RR 64

  Fly    68 TGRLKDNLKKLEDLLRQHRIIHSEWQDAAQVLLLFSHGLIAHICVDIYTG--DILRMVFEKYLVG 130
            ..:|:|.||:||:||:...::...|:......:|...|::    |.:..|  .:.|:|.::.|||
Zfish    65 PEKLRDALKELEELLQSCPVMSVRWRSKQCCQMLLRSGVL----VTLILGGAQVERVVIDRTLVG 125

  Fly   131 KLASEVITDAFFTRSHIVLA-YNTNQLTVVHLQRPNARS----QGPEKIANMDPRIFHVIIPGAT 190
            :|.::.|:||......::.: ...:|:..|:|.|.|..|    :..||:...:.::....:||.
Zfish   126 RLPADTISDAVIGDRFLLFSLMERSQVCQVYLNRKNQSSPDLARHMEKLTAAEIKVSVADLPGG- 189

  Fly   191 ERKLSRHLTVNASFDLFVVWTQSSQNEVYPWRPTIRDQDRANIHVFKIK---GLQ-LESIAYCWS 251
            .|::.|||.:|.:.|:.|.|......||.||.|.....||||:.:....   ||. |.||.   :
Zfish   190 GRRVERHLGLNRTQDVAVCWWPLCNEEVRPWSPIPSAADRANLVLLACSDTPGLTVLSSIR---T 251

  Fly   252 ENDPLCVDFLRSSESQIITLEQKVSRKGDISAEI----------CSYELAAGKMQRTAITSIPMG 306
            :.||:...|..:....|:|:|.....|...|..:          |.|||..|::||.:..|:.:.
Zfish   252 DGDPIDCRFSLTQPYHILTVELHQDTKHSTSESLEEIQHPDIQTCVYELTRGRLQRLSSISLTLT 316

  Fly   307 AQICSFAFSPDQEKLFLGSVDRNICLHDLVQQSTKYANQIEIVPNQCAWHCDSAMLCVANERSVL 371
            ::..:.:..|.:..:.||..|.::.|.|.....:::|. ..::|...|||...::|.|...:..|
Zfish   317 SKPITCSRDPLERWVVLGLQDCSVVLFDPQTGLSQWAT-CSMMPAVLAWHPSGSLLVVGGGQGEL 380

  Fly   372 QCFDLALATIGHQLVSENVTPSSL---LDLSHYFVAQPTLLSVAFSRKPDLSTFKHTYAQTDCLL 433
            ||||:..:.:..:||||...|.|:   |.||.:|.....|..:.::..| :|....:....| ||
Zfish   381 QCFDMGFSPLPLRLVSEEPVPGSVGSSLQLSQHFNTSEGLEGIQWAYCP-ISQGNESLEVHD-LL 443

  Fly   434 LLVYEQGPLACMR----IFGGTGMRGDIHNSGLTADVIADKYLRLQQPDRAVNVLAALNWETYGA 494
            ||.:..||||.:|    :|.|..:.        ..|:|..:.| .::.|.|:.:|..::|...||
Zfish   444 LLRFHGGPLAALRLKLGVFNGAQLG--------PCDLILHRLL-CEEVDAALGILGNMDWAIMGA 499

  Fly   495 MCLITLHKIANYVFFGGDQRRPRIE----LMARALKTF---AHTLSEETKDEFSDQVYDLKRRFC 552
            .|..:|..|.:::.     |:|..:    .:..||..|   ...||.....|:.|.:....|||.
Zfish   500 ECYRSLISITDHLL-----RKPLDQQTEGQLEAALGVFYAPCRPLSNTVILEYRDPISRYARRFF 559

  Fly   553 FYLLRKNLFAEAFEIAQDVADYDIFMDLYNLTKCISSLSEFAQVAFSQAAAIIHEEDRANGNLSL 617
            .:|||...|.:||.:|.|:...|:||||:.:.      ::..:|..:..|     :.:||
Zfish   560 HHLLRHQRFEKAFLLAVDIGARDLFMDLHYVA------ADKGEVVLAAVA-----KKKAN----- 608

  Fly   618 TCDLRSESACSL-STCSDMLRGQGAGTAPET-----------------GLGASQPQSQQVLKNYV 664
              ::.:|:..|. ..|.....||.....|.|                 .:..|..::|..|.|..
Zfish   609 --EIDAEAQTSAPDECQSAYGGQSGVKLPATISERHVHDLKHWSTASRAVETSSSKAQDDLSNTQ 671

  Fly   665 PPLPSFKSKVFNAEMIKINIPKPE 688
            ....|:..|.....::..|...||
Zfish   672 TSHSSWPWKHTEINLVDQNTQGPE 695

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
frtz	NP_001259879.1	DUF3312	47..596	CDD:288601	154/583 (26%)
frtz	NP_001259879.1	WD40	<308..384	CDD:295369	18/75 (24%)
wdpcp	XP_005158592.1	DUF3312	47..603	CDD:288601	155/589 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574873
Domainoid	1	1.000	166	1.000	Domainoid score	I3847
eggNOG	1	0.900	-	-		E1_28IXA
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9299
Inparanoid	1	1.050	173	1.000	Inparanoid score	I4074
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D306370at33208
OrthoFinder	1	1.000	-	-		FOG0007139
OrthoInspector	1	1.000	-	-		oto39114
orthoMCL	1	0.900	-	-		OOG6_107800
Panther	1	1.100	-	-	LDO	PTHR13667
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7664
SonicParanoid	1	1.000	-	-		X5237
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	15	14.830