DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17660 and Tmem87b

DIOPT Version :9

Sequence 1:	NP_608612.3	Gene:	CG17660 / 33347	FlyBaseID:	FBgn0031356	Length:	536	Species:	Drosophila melanogaster
Sequence 2:	NP_001342557.1	Gene:	Tmem87b / 72477	MGIID:	1919727	Length:	563	Species:	Mus musculus

Alignment Length:	553	Identity:	228/553 - (41%)
Similarity:	327/553 - (59%)	Gaps:	44/553 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 ATLLVVALALLLG-PASTAGKSDPGMVDVLVTTDLPSIREQRPLLANTKIYAQIKGCTSNVESNL 68
            |.||.|||.||.. ||:.....:.|:....|......:..::.:..:|:|...:|..:.:.....
Mouse    23 AQLLRVALCLLCWVPAAVDAVPELGLWTRTVNDKSGPLVFRKTMFNSTEIKFSVKSFSCSGPVKF 87

  Fly    69 TITFRLTEHPCIFDDRTL-QAIAQNATLQKN----ATINNVITEITRTYPCNGLIVLAINKDKVV 128
            ||.:.|..|.|..|...| :.::|...|..:    |...|:....|::.          |.|...
Mouse    88 TIEWHLKYHTCHNDYPDLEEELSQRHELHADPDVCAYFKNIDCWTTKSE----------NLDCSS 142

  Fly   129 EGSAIPTPEPKH-PMLEHKHPLSPTTNPIASVKEDGIYEIEVNIAAGPS-AQFSAVVHIEFLGPH 191
            :..|.|:...|. ..:.:......:|:.:|..::||.:...|:|....: |.:...|.:..:|||
Mouse   143 DSQAFPSLNNKELTGIRNISSQEGSTDVVARTQKDGFHIFIVSIKTEKTDAVWDLNVSLSMVGPH 207

  Fly   192 GFISAIDWPFLPFYLIMCIVYVIFGIIWLFVSFAQWRDLLRIQFWIGGVILLGMLEKAFFYAEYQ 256
            |:|||.|||.:.||::|||||:::|::||..|...|:|:|||||||..||.|||||||.||:|||
Mouse   208 GYISASDWPLMIFYMVMCIVYILYGVLWLLWSACYWKDILRIQFWIAAVIFLGMLEKAVFYSEYQ 272

  Fly   257 TLTNKGVAVQHAELVAEFVSCAKRTLARMLVIIMSLGFGIVKPRLGPMLHRVVGVGTLYFVLACV 321
            .:.:.|::.|...:.||.:|..||||||:||||:|||:||||||||.::|||:|:|.||.:.|.:
Mouse   273 NINSTGLSTQGLLIFAELISAVKRTLARLLVIIVSLGYGIVKPRLGTVMHRVIGLGLLYLIFAAI 337

  Fly   322 ESYLRITNVKTDRSELLVASIPLAVLDTGICWWI-FT-------SLVQTTRTLRLRRNMVKLSLY 378
            |..:|:.. .:....:::..|.|||:|:...|:| ||       .|.||.:|||||:|.||.|||
Mouse   338 EGVMRVIG-GSKHLAVVLTDIVLAVIDSIFVWFISFTMSFQNSWCLAQTMKTLRLRKNTVKFSLY 401

  Fly   379 RHFTNTLIFAVIASVIFMLFALRLRRVENCTPGWRDIWVDTGFWHILFSVLLLVIMILWRPTNNN 443
            |||||||||||:||::||::..:..|:..|...|.::|||..||..||||:|:|||.||||:.||
Mouse   402 RHFTNTLIFAVLASIVFMVWTTKTFRIAKCQSDWMELWVDDAFWSFLFSVILIVIMFLWRPSANN 466

  Fly   444 QRYAFTPLLDNPEDEDDEDEEDQFVAD--AYGVKMRG----QNGTPKTSTTSRNATTTEEDDLRW 502
            |||||.||:|   |.|||.||....::  ..|:|:|.    .|||.|  .||.|.    ::||:|
Mouse   467 QRYAFMPLID---DSDDEVEEFMVTSENLTEGIKLRASKTVSNGTAK--PTSDNF----DEDLKW 522

  Fly   503 VEENIPSSMADSALPIL-DSDEEIINTKFEVSK 534
            ||||||||..|.|||:| ||||||: |:.|:::
Mouse   523 VEENIPSSFTDVALPVLVDSDEEIM-TRSEIAE 554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17660	NP_608612.3	Lung_7-TM_R	160..444	CDD:284280	145/292 (50%)
Tmem87b	NP_001342557.1	Lung_7-TM_R	175..467	CDD:284280	145/292 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833556
Domainoid	1	1.000	316	1.000	Domainoid score	I1271
eggNOG	1	0.900	-	-		E1_KOG2568
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H69513
Inparanoid	1	1.050	388	1.000	Inparanoid score	I1995
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1448608at2759
OrthoFinder	1	1.000	-	-		FOG0001340
OrthoInspector	1	1.000	-	-		otm44056
orthoMCL	1	0.900	-	-		OOG6_101701
Panther	1	1.100	-	-	O	PTHR21229
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1798
SonicParanoid	1	1.000	-	-		X1432
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790