DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17660 and TMEM87A

DIOPT Version :9

Sequence 1:	NP_608612.3	Gene:	CG17660 / 33347	FlyBaseID:	FBgn0031356	Length:	536	Species:	Drosophila melanogaster
Sequence 2:	XP_005254344.1	Gene:	TMEM87A / 25963	HGNCID:	24522	Length:	556	Species:	Homo sapiens

Alignment Length:	578	Identity:	224/578 - (38%)
Similarity:	326/578 - (56%)	Gaps:	64/578 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MQGSATLLVVALALLL-------------GPASTAGKSDPGMVDVLVTTDLPSIREQRPLLANTK 52
            |..:|.|.|:.:.|||             |||:.|. :|.....:.:.:........:.|..||.
Human     1 MAAAAWLQVLPVILLLLGAHPSPLSFFSAGPATVAA-ADRSKWHIPIPSGKNYFSFGKILFRNTT 64

  Fly    53 IYAQIKG--CTSNVESNLTITFRLTEHPC-------------IFDDRTLQAIAQNATLQKNATIN 102
            |:.:..|  |    :.:|.||:.|....|             ::.::..:....:...|.::.:.
Human    65 IFLKFDGEPC----DLSLNITWYLKSADCYNEIYNFKAEEVELYLEKLKEKRGLSGKYQTSSKLF 125

  Fly   103 NVITEITRTYPCNG-----LIVLAINKDKVVEGSAIPTPEPKHPMLEHKHPLSPTTNPIASVKED 162
            ...:|:.:|...:|     |.:|...::....|:.:.....|..|.|   ||        ...:|
Human   126 QNCSELFKTQTFSGDFMHRLPLLGEKQEAKENGTNLTFIGDKTAMHE---PL--------QTWQD 179

  Fly   163 GIYEIEVNIAAGPSAQFSA--------VVHIEFLGPHGFISAIDWPFLPFYLIMCIVYVIFGIIW 219
            ..|...|:|....|.:.|.        .:.:|..||:.:::..|:|.:.|:::||||||:||::|
Human   180 APYIFIVHIGISSSKESSKENSLSNLFTMTVEVKGPYEYLTLEDYPLMIFFMVMCIVYVLFGVLW 244

  Fly   220 LFVSFAQWRDLLRIQFWIGGVILLGMLEKAFFYAEYQTLTNKGVAVQHAELVAEFVSCAKRTLAR 284
            |..|...||||||||||||.||.|||||||.||||:|.:..||.:||.|.::||.:|..||:|||
Human   245 LAWSACYWRDLLRIQFWIGAVIFLGMLEKAVFYAEFQNIRYKGESVQGALILAELLSAVKRSLAR 309

  Fly   285 MLVIIMSLGFGIVKPRLGPMLHRVVGVGTLYFVLACVESYLRITNVKTDRSELLVASIPLAVLDT 349
            .||||:|||:||||||||..||:||..|.||.:.:.:|..||:|...:....|:| ::.|:.:|.
Human   310 TLVIIVSLGYGIVKPRLGVTLHKVVVAGALYLLFSGMEGVLRVTGYFSYPLTLIV-NLALSAIDA 373

  Fly   350 GICWWIFTSLVQTTRTLRLRRNMVKLSLYRHFTNTLIFAVIASVIFMLFALRLRRVENCTPGWRD 414
            .:..|||.||.||.:.|:||||:||||||||||||||.||.||::|:::.....|:..|...||:
Human   374 CVILWIFISLTQTMKLLKLRRNIVKLSLYRHFTNTLILAVAASIVFIIWTTMKFRIVTCQSDWRE 438

  Fly   415 IWVDTGFWHILFSVLLLVIMILWRPTNNNQRYAFTPLLDNPEDEDDEDEEDQFVADAYGVKMRGQ 479
            :|||...|.:|||::|.|||:||||:.||||:||:||  :.|:|:||.:|........|:|||..
Human   439 LWVDDAIWRLLFSMILFVIMVLWRPSANNQRFAFSPL--SEEEEEDEQKEPMLKESFEGMKMRST 501

  Fly   480 NGTPKTSTTSRNATTTEEDDLRWVEENIPSSMADSALP-ILDSDEEIINTKFEVSKMQ 536
            ...|..::....|   :||||:|||||:|||:.|.||| :||||||.:.|.||.|||:
Human   502 KQEPNGNSKVNKA---QEDDLKWVEENVPSSVTDVALPALLDSDEERMITHFERSKME 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17660	NP_608612.3	Lung_7-TM_R	160..444	CDD:284280	143/291 (49%)
TMEM87A	XP_005254344.1	Lung_7-TM_R	206..468	CDD:284280	137/262 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143389
Domainoid	1	1.000	314	1.000	Domainoid score	I1288
eggNOG	1	0.900	-	-		E1_KOG2568
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	386	1.000	Inparanoid score	I2035
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1448608at2759
OrthoFinder	1	1.000	-	-		FOG0001340
OrthoInspector	1	1.000	-	-		otm42003
orthoMCL	1	0.900	-	-		OOG6_101701
Panther	1	1.100	-	-	O	PTHR21229
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1798
SonicParanoid	1	1.000	-	-		X1432
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.790