DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cpb and CAPZB

DIOPT Version :9

Sequence 1:	NP_001259877.1	Gene:	cpb / 33346	FlyBaseID:	FBgn0011570	Length:	276	Species:	Drosophila melanogaster
Sequence 2:	XP_011540530.1	Gene:	CAPZB / 832	HGNCID:	1491	Length:	306	Species:	Homo sapiens

Alignment Length:	276	Identity:	213/276 - (77%)
Similarity:	244/276 - (88%)	Gaps:	2/276 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SEMQMDCALDLMRRLPPQQIEKNLIDLIDLAPDLCEDLLSSVDQPLKIAKDKEHGKDYLLCDYNR 66
            |:.|:|||||||||||||||||||.|||||.|.||||||||||||||||:||..|||||||||||
Human    31 SDQQLDCALDLMRRLPPQQIEKNLSDLIDLVPSLCEDLLSSVDQPLKIARDKVVGKDYLLCDYNR 95

  Fly    67 DGDSYRSPWSNSYYPPLEDGQMPSERLRKLEIEANYAFDQYREMYYEGGVSSVYLWDLDHGFAAV 131
            |||||||||||.|.||||||.|||.||||||:|||.||||||::|:|||||||||||||||||.|
Human    96 DGDSYRSPWSNKYDPPLEDGAMPSARLRKLEVEANNAFDQYRDLYFEGGVSSVYLWDLDHGFAGV 160

  Fly   132 ILIKKAGDGSKMIRGCWDSIHVVEVQEKTTGRTAHYKLTSTAMLWLQTNKQGSGTMNLGGSLTRQ 196
            |||||||||||.|:||||||||||||||::|||||||||||.||||||||.||||||||||||||
Human   161 ILIKKAGDGSKKIKGCWDSIHVVEVQEKSSGRTAHYKLTSTVMLWLQTNKSGSGTMNLGGSLTRQ 225

  Fly   197 QEQDANVSESSPHIANIGKMVEEMENKIRNTLNEIYFGKTKDIVNGLRSTQSLADQRQQAAMKQD 261
            .|:|..||:.||||||||::||:||||||:|||||||||||||||||||..::.|.::...::::
Human   226 MEKDETVSDCSPHIANIGRLVEDMENKIRSTLNEIYFGKTKDIVNGLRSIDAIPDNQKFKQLQRE 290

  Fly   262 LAAAILRRN--VKPES 275
            |:..:.:|.  ::|::
Human   291 LSQVLTQRQIYIQPDN 306

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cpb	NP_001259877.1	F_actin_cap_B	11..239	CDD:395885	195/227 (86%)
CAPZB	XP_011540530.1	F_actin_cap_B	40..268	CDD:279459	195/227 (86%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146880
Domainoid	1	1.000	423	1.000	Domainoid score	I623
eggNOG	1	0.900	-	-		E1_KOG3174
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3620
Inparanoid	1	1.050	448	1.000	Inparanoid score	I1628
Isobase	1	0.950	-	0	Normalized mean entropy	S406
OMA	1	1.010	-	-		QHG54327
OrthoDB	1	1.010	-	-		D1076134at2759
OrthoFinder	1	1.000	-	-		FOG0004437
OrthoInspector	1	1.000	-	-		oto90574
orthoMCL	1	0.900	-	-		OOG6_103032
Panther	1	1.100	-	-	LDO	PTHR10619
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4497
SonicParanoid	1	1.000	-	-		X3143
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750