DRSC/TRiP Functional Genomics Resources

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Protein Alignment chinmo and Hic2

DIOPT Version :9

Sequence 1:NP_001188680.1 Gene:chinmo / 33343 FlyBaseID:FBgn0086758 Length:840 Species:Drosophila melanogaster
Sequence 2:NP_849253.2 Gene:Hic2 / 58180 MGIID:1929869 Length:619 Species:Mus musculus


Alignment Length:627 Identity:129/627 - (20%)
Similarity:208/627 - (33%) Gaps:156/627 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 SFSSNLAITFSNLFKSDLLADVILSCDGVVFKAHKLILAACSKKFADL-----FENTPTNGQCVI 72
            |.|..|.:..:.......|.|||:..:..:|:|||.:|||.|..|..|     ..|..|:     
Mouse    27 SHSKQLLLQLNQQRAKGFLCDVIIMVENSIFRAHKNVLAASSIYFKSLVLHDNLINLDTD----- 86

  Fly    73 ILEATTPDNMAALLEFMYKGEV----HVSQEALNSFLKSAESLQVKGLSTETGRLAAQQAQQHMG 133
            ::.:|.   ...:|:|:|.|::    ..|:...::.|.:|..||:..|:. ..|...::|.:..|
Mouse    87 MVSSTV---FQQILDFIYTGKLLPSDQPSEPNFSTLLTAASYLQLPELAA-LCRRKLKRAGKPFG 147

  Fly   134 ----DLSPLDSPTGRRSVRNSLSGGSSSIVPGGVGIGLG-------GGATGANSMSGMGIGNGLS 187
                ..:.:..||  ||.|.|.:....:..||.|.:..|       ..|.|::....:|.....|
Mouse   148 PGRVGTAGIGRPT--RSQRLSTASVIQARFPGLVDVRKGHPAPQELPQAKGSDDELFLGTSTQES 210

  Fly   188 LAGMAAGGGMAAAANAAASSLSTLAASANIVDRCG-------------SAGANIISGSAAGIGGS 239
            ..|:..||...........|.||..:|.......|             :.|.::.....|.:..|
Mouse   211 THGLGLGGPAGGEMGLGGCSTSTNGSSGGCEQELGLDLSKKSPPLPPTTPGPHLTPEDPAQLSDS 275

  Fly   240 HSGG----------AGNGSGTVGIGG---NGVGSGGGNNGPISLGSGAGAAHHLGGSTGILKQEC 291
            ....          .||.:..|.:|.   ..:...|.....:||..|.|.            |..
Mouse   276 QRESPAPTSTSALPVGNSASFVELGATPEEPMDVEGAEENHLSLLEGQGG------------QPR 328

  Fly   292 DSLMHPGGSSSSSGMGYTHVPPIYRPINYEPPRKRAIVRSPYSEQEQRGSVLRDGSKSSECPSPI 356
            .||.|.......:                   :|..:..||:..:|       .|||.| ||   
Mouse   329 KSLRHSARKKDWN-------------------KKEPVAGSPFDRRE-------TGSKGS-CP--- 363

  Fly   357 NKPPYHRPSSSASSTAPTEADTMHSERASPQSSRYENHSPSTTAGNGNATSSLER---IVKSERN 418
                                    .|.......|..|...:::||.|..::|...   ..|.|..
Mouse   364 ------------------------GEEGEGTGDRVPNGVLASSAGGGGPSASYGEQSFPCKEEEE 404

  Fly   419 NGSANEANDDDRELMDE--STDNGAEDL--RVKLENLKYSPP-----PPPNSNTSSTTPNTLLEN 474
            ||  .:.::|..:...|  |...||..:  :...|.:.|...     |......||...|..:|.
Mouse   405 NG--KDGSEDSGQSGSEGGSGHTGAHYVYRQEGYETVSYGDNVYVCIPCAKGFPSSEQLNAHVET 467

  Fly   475 -------LKADGTLSSNLAASIAPADMLNVWNATKMNNKNSVNTADGKKLKCLYCDRLYGYETNL 532
                   :|.:|...:....:...|:        .::..::..|||.:..||..|::.|.....|
Mouse   468 HTEEELFIKEEGAYETGSGGAEEEAE--------DLSTPSAAYTADSRPFKCSVCEKTYKDPATL 524

  Fly   533 RAHIRQRHQGIRVPCPFCERTFTRNNTVRRHIAREHKQEIGL 574
            |.|.:........||..|.:.||:..|:.||: |.|   :||
Mouse   525 RQHEKTHWLTRPFPCNICGKMFTQRGTMTRHM-RSH---LGL 562

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
chinmoNP_001188680.1 BTB 22..116 CDD:279045 26/102 (25%)
BTB 33..116 CDD:197585 25/91 (27%)
C2H2 Zn finger 519..540 CDD:275368 6/20 (30%)
C2H2 Zn finger 547..568 CDD:275368 8/20 (40%)
Hic2NP_849253.2 BTB 40..140 CDD:279045 28/108 (26%)
BTB 47..141 CDD:197585 27/102 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 180..293 17/112 (15%)
Binding to CtBP. /evidence=ECO:0000250 247..249 0/1 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 307..426 33/186 (18%)
C2H2 Zn finger 448..468 CDD:275368 5/19 (26%)
zf-C2H2 509..531 CDD:278523 7/21 (33%)
C2H2 Zn finger 511..531 CDD:275368 6/19 (32%)
zf-C2H2 537..559 CDD:278523 9/22 (41%)
C2H2 Zn finger 539..559 CDD:275368 8/20 (40%)
zf-H2C2_2 552..576 CDD:290200 6/15 (40%)
COG5048 563..>617 CDD:227381 129/627 (21%)
C2H2 Zn finger 567..587 CDD:275368
zf-H2C2_2 580..604 CDD:290200
C2H2 Zn finger 595..615 CDD:275368
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
00.000

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