DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment chinmo and zbtb17

DIOPT Version :9

Sequence 1:	NP_001188680.1	Gene:	chinmo / 33343	FlyBaseID:	FBgn0086758	Length:	840	Species:	Drosophila melanogaster
Sequence 2:	XP_003201251.1	Gene:	zbtb17 / 564967	ZFINID:	ZDB-GENE-090313-240	Length:	856	Species:	Danio rerio

Alignment Length:	933	Identity:	159/933 - (17%)
Similarity:	264/933 - (28%)	Gaps:	347/933 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 LLADVILSCDGVVFKAHKLILAACSKKFADLFENTPTNGQCVIILEATTPDNMAALLEFMYKGEV 94
            ||.|.....|||.|||||.:|||||..|..||    .:.:.|:.|:.:....:..:|||||..::
Zfish    22 LLCDCTFVVDGVDFKAHKAVLAACSSYFRTLF----LDQKDVVHLDISNAAGLEQVLEFMYTAKL 82

  Fly    95 HVSQEALNSFLKSAESLQVKGLSTETGRLAAQQAQQHMGDLS--------PLDSPTGRRSVRNSL 151
            .::.:.:...|..|..||::.:      :.|..|.|.:...|        ||:..|  :||:...
Zfish    83 TLNAQNIEDVLAVATFLQMQEI------VNACSAFQSLTVSSAPKPVVTEPLEEQT--KSVKKPE 139

  Fly   152 SGGSSSIVPGGVGIGLGGGATGANSMSGMGIGNGLSLAGMAAGGGMAAAANAAASSLSTLAASAN 216
            ...|.|:.                                ...|.....|.:.:.:..|..|.:|
Zfish   140 EPDSHSVT--------------------------------QKAGPEEKEAQSQSKTEETHEAVSN 172

  Fly   217 IVDRCGSAGANIISGSAAGIGGSHSGGAGNGSGTVGIGGNGVGSGGGNNGPISLGSGAGAAHHLG 281
            :.:
Zfish   173 VAE-------------------------------------------------------------- 175

  Fly   282 GSTGILKQECDSLMHPGGSSSSSGMGYTHVPPIYRPINYEPPRKRAI--VRSPYSEQEQRGSVLR 344
                  ||...:|                               ||:  :..|...::      :
Zfish   176 ------KQSTKTL-------------------------------RAVSKISGPLKTRQ------K 197

  Fly   345 DGSKSSECPSPINKPPYHRPSSSASSTAPTEADTMHSERASPQSSRYEN-----HSPSTTAGNGN 404
            |....||......:.|..:...:.:...|..:..|.::|:...:.|.::     |:.:.......
Zfish   198 DSKSESEAERATKELPQFQDDPNDADYTPKLSQRMVAKRSVVSTRRSKSKYATVHTAAEVNDGEE 262

  Fly   405 ATSSLERIVKSERNNGSANEANDDDR------------ELMD-------------ESTDNGA--- 441
            :.|.:|.:|:.|..:....|..:||:            |:||             ||...|:
Zfish   263 SVSKVESMVEEENEDDGGEEDLEDDQTDGEEEMETEDGEMMDSEDRKFAIGAERTESRSYGSITH 327

  Fly   442 --EDLRVKLE-----------------------NLKYSPPPPPNSNTSSTTP------------- 468
              ||...|..                       |..:|.|....::..:.:|
Zfish   328 KCEDCGKKFTHTGNFKRHMRIHTGEKPFTCRDCNKAFSDPAACKAHEKTHSPVKPYCCSTCGKSY 392

  Fly   469 -NTLLENLKADG----------------TLSSNLA------ASIAP-----ADMLNVWNATKMNN 505
             ...|.||....                |.|.||.      :...|     .|........||.:
Zfish   393 RQISLLNLHRKRHTDEARYSCEDCGKLFTTSGNLKRHQLVHSGEKPYQCDHCDRAFSDPTAKMRH 457

  Fly   506 KNSVNTADGKKLKCLYCDRLYGYETNLRAHIRQRHQGIRVPCPFCERTFTRNNTVRRHIAREHKQ 570
            ..:.:|..|.  ||.:||:.:....||:||::.......:.|..|.:.||.:..::||: |.|..
Zfish   458 LETHDTDKGH--KCQHCDKKFNQVGNLKAHLKIHIADGPLKCKECGKQFTTSGNLKRHL-RVHSG 519

  Fly   571 EIGLAAGATIAPAHLAAAAAASAAATAAASNHSPXEAAA--------TAAASVVMNANKEAAKQ- 626
            |      ......|...|.|...|.......|:. :...        |.|:|::.:..:...::
Zfish   520 E------KPFICMHCQRAFADPGALQRHVRIHTGEKPCLCLICGKGFTQASSLIAHVRQHTGEKP 578

  Fly   627 ------RKRKTLKMALEKCMQRRDAMVAETTTGAGGDGAEAGGESGEAVDGAGSEE------GAG 679
                  .||......|...::..|.:...............|..|...:...|.:.      |.|
Zfish   579 YVCDRCGKRFVQSSQLANHIRHHDNIRPHKCQTCNKAFVNVGDLSKHIIIHTGEKPFLCDKCGRG 643

  Fly   680 SEGTEPLTYEQQQQRMHQELTQQIRAAMAAEQAAE------------AMDSTMNT------TVNT 726
            ....:.|       |.|.:...|.:|.|.....||            ..||.:::      ||.|
Zfish   644 FNRVDNL-------RSHVKTVHQGKAGMKRLVVAEDDDGEDKLLADSNPDSELDSNEVNIVTVTT 701

  Fly   727 TTTTTTTTNTTGATSDGCSDAEASDGSDRPMEVDEDQPPEPQPGSELVVVEPKIEVLSESEDEED 791
            ....|..|....||:                            .::|.||.....|   |.||.:
Zfish   702 DDIVTLATEALAATT----------------------------VAQLTVVPVAASV---SADETE 735

  Fly   792 RLHMSEAEPDIQAEAIYDHMPNT 814
            .|   :||.....|.:.:..|||
Zfish   736 AL---KAEITKAVEKVQEADPNT 755

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
chinmo	NP_001188680.1	BTB	22..116	CDD:279045	30/85 (35%)
		BTB	33..116	CDD:197585	28/82 (34%)
		C2H2 Zn finger	519..540	CDD:275368	7/20 (35%)
		C2H2 Zn finger	547..568	CDD:275368	7/20 (35%)
zbtb17	XP_003201251.1	BTB	14..111	CDD:279045	31/98 (32%)
		BTB	25..111	CDD:197585	29/95 (31%)
		YtxH	<141..222	CDD:295162	17/217 (8%)
		COG5048	326..654	CDD:227381	56/343 (16%)
		zf-C2H2	327..349	CDD:278523	3/21 (14%)
		C2H2 Zn finger	329..349	CDD:275368	3/19 (16%)
		zf-H2C2_2	341..365	CDD:290200	1/23 (4%)
		C2H2 Zn finger	357..377	CDD:275368	3/19 (16%)
		C2H2 Zn finger	385..405	CDD:275368	3/19 (16%)
		zf-C2H2	411..433	CDD:278523	4/21 (19%)
		C2H2 Zn finger	413..433	CDD:275368	4/19 (21%)
		zf-H2C2_2	425..449	CDD:290200	4/23 (17%)
		C2H2 Zn finger	441..461	CDD:275368	3/19 (16%)
		zf-C2H2	467..489	CDD:278523	8/23 (35%)
		C2H2 Zn finger	469..489	CDD:275368	7/19 (37%)
		zf-H2C2_2	481..506	CDD:290200	7/24 (29%)
		zf-C2H2	496..517	CDD:278523	7/21 (33%)
		C2H2 Zn finger	497..517	CDD:275368	7/20 (35%)
		zf-H2C2_2	509..533	CDD:290200	7/30 (23%)
		C2H2 Zn finger	525..545	CDD:275368	4/19 (21%)
		zf-H2C2_2	537..562	CDD:290200	2/24 (8%)
		C2H2 Zn finger	553..573	CDD:275368	3/19 (16%)
		zf-H2C2_2	565..590	CDD:290200	3/24 (13%)
		C2H2 Zn finger	581..601	CDD:275368	3/19 (16%)
		C2H2 Zn finger	609..629	CDD:275368	2/19 (11%)
		zf-H2C2_2	621..646	CDD:290200	4/24 (17%)
		C2H2 Zn finger	637..656	CDD:275370	5/25 (20%)
		C2H2 Zn finger	761..781	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	0	0.000