DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment chinmo and ab

DIOPT Version :9

Sequence 1:	NP_001188680.1	Gene:	chinmo / 33343	FlyBaseID:	FBgn0086758	Length:	840	Species:	Drosophila melanogaster
Sequence 2:	NP_476562.1	Gene:	ab / 34560	FlyBaseID:	FBgn0264442	Length:	904	Species:	Drosophila melanogaster

Alignment Length:	940	Identity:	202/940 - (21%)
Similarity:	309/940 - (32%)	Gaps:	301/940 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 QQQFCLKWNSFSSNLAITFSNLFKSDLLADVILSCDGVVFKAHKLILAACSKKFADLFENTPTNG 68
            ||.:.||||.|.|::..:|.:|...:...||.|:||...|.|||::|:|||..|..|.:..|
  Fly    75 QQHYALKWNDFQSSILSSFRHLRDEEDFVDVTLACDERSFTAHKVVLSACSPYFRRLLKANP--- 136

  Fly    69 QC---VIILEATTPDNMAALLEFMYKGEVHVSQEALNSFLKSAESLQVKGLSTETGRLAAQQAQQ 130
             |   ::||.....|::..||.|||.|||:||.|.|..|||:|..||::||:...|.....:|
  Fly   137 -CEHPIVILRDVRCDDVENLLSFMYNGEVNVSHEQLPDFLKTAHLLQIRGLADVNGGYPYSKA-- 198

  Fly   131 HMGDLSPLDSPTGRRSVRNSLSGGSSSIVPGGVGIGLGGGATGANSMSGMGIGNGLSLAGMAAGG 195
                   |.:.....|..|:.:..||:                 ||:|.....|.
  Fly   199 -------LSAALSHNSSNNNNNNSSSN-----------------NSLSNNNNNNN---------- 229

  Fly   196 GMAAAANAAASSLSTLAASANIVDRCGSAGANIISGSAAGIGGSHSGGAGNG-SGTVGIGGNGVG 259
                  |.|.||.....:|....::..:|..|..:.::.....||:..:.|. ||::....|...
  Fly   230 ------NNAESSNHNKISSYLSPNQTSAACNNSSNSNSNNHSSSHNNSSSNNISGSLNSSLNSPF 288

  Fly   260 SGGGNNGPISLGSGAGAAHHLGGSTGILKQECDSLMHPGGSSSSSGMGYTHVPPIYRPINYEPPR 324
            |......|::..|.|.||......|..:.....:.....|||||:..|.|...|..:.:
  Fly   289 SAPQIPPPVTASSAAAAAAAAASLTAAVAAAAAATAASAGSSSSAASGQTSGTPAIQEL------ 347

  Fly   325 KRAIVRSPYSEQEQRGSVLRDGSKSSECPSPINKP-PYHRPSSSASS----------------TA 372
                                   |:|...||:..| |  .||.::||                |.
  Fly   348 -----------------------KASSAASPVRNPNP--NPSKASSSNHWDMGEMEGSRKSHLTP 387

  Fly   373 PTE-----ADTMHSERA-SPQSSRYENHSPSTTAGNGNATSSLERIVKSERNNGSANEANDDDR- 430
            |.:     ||...::.. ||:....:...|  .||....|          ||....:.:.|.:|
  Fly   388 PPQKRIKSADLFRAQHGISPERLLLDREFP--VAGQHPLT----------RNRSGRDTSKDRERN 440

  Fly   431 -ELMDESTDNGAEDLRVKLENLKY--SPPPPPNSNTSSTTPNTLLENLKADGTLS--SNLAASIA 490
             ||.:.......|:...:..|.|:  ......:||:|.|.|:...:. :.||||.  .|..:...
  Fly   441 LELRESLLGQALENSNGQQANPKHELGQSAGEDSNSSDTEPSDRGDG-QHDGTLDGIDNQRSHSF 504

  Fly   491 PADMLNVWN---------------ATKMNNKNSVNTADGKKLKCLYCDRLYGYETNLRAHIRQRH 540
            |...|.:..               .::.:.:..|...|.:  .|..|.::|.....||.|:..:|
  Fly   505 PNAFLGLQGIPGLLPGPSGINSDFVSRRSLEMRVRATDPR--PCPKCGKIYRSAHTLRTHLEDKH 567

  Fly   541 ---QGIRVPCPFCERTFTRNNTVRRHIAREHKQEIGLA------------------------AGA 578
               .|.|  |..|.......|::..|::|:|:   |::                        ||.
  Fly   568 TVCPGYR--CVLCGTVAKSRNSLHSHMSRQHR---GISTKDLPVLPMPSAFDPELASRLLAKAGV 627

  Fly   579 TIAPAHLAAAAAASAAATAAASNHSPXEAAATAAASVVMNANKEAAKQRKRKTLKMALEKCMQRR 643
            .|:||.|.|.|             || ..:.::.
  Fly   628 KISPAELRARA-------------SPTGGSGSSG------------------------------- 648

  Fly   644 DAMVAETTTGAGGDGAE---------AGGESGEAVDGAGSEE---------GAGSEGTEPLTYEQ 690
                     |.||.|:.         :||...:|.|.....|         |.|...::...|.:
  Fly   649 ---------GGGGGGSSQAKLDLSNASGGPMDDAEDSDDDPEDLTTGNGLYGMGGSSSDLSRYHE 704

  Fly   691 Q------QQRMHQELTQQIRAAMAAEQAAEAMDSTMNT----------TVNTTTTTTTTTNTTGA 739
            .      ..||..|     .||:||..||......:..          ::..|.....|.||.|.
  Fly   705 SLLSNFGHARMRNE-----AAAVAATAAALGQPKDLGVQLPNSNAPGQSLLDTYLQFITENTFGM 764

  Fly   740 TSDGCSDAEASDGSDRPMEVD--------EDQPPEPQPG----SELVVVEPKIEVLSESEDEEDR 792
               |.|..:|:..:.|.....        ::.||...||    |:|....|.
  Fly   765 ---GMSQEQAAAAALRAKMAQLNAMGHSLDNLPPGLLPGQFDLSKLAAGNPA------------- 813

  Fly   793 LHMSEAEPDIQAEAIYDH-------MPNTP 815
              ..::.|.:..|.|..|       .||.|
  Fly   814 --FGQSGPGLTIEPIMRHEQAAGNLSPNRP 841

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
chinmo	NP_001188680.1	BTB	22..116	CDD:279045	40/96 (42%)
		BTB	33..116	CDD:197585	38/85 (45%)
		C2H2 Zn finger	519..540	CDD:275368	6/20 (30%)
		C2H2 Zn finger	547..568	CDD:275368	5/20 (25%)
ab	NP_476562.1	BTB	93..189	CDD:279045	42/99 (42%)
		BTB	104..189	CDD:197585	40/88 (45%)
		zf-Di19	545..597	CDD:283297	14/53 (26%)
		C2H2 Zn finger	546..567	CDD:275371	6/20 (30%)
		C2H2 Zn finger	575..596	CDD:275371	5/20 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	68	1.000	Domainoid score	I9675
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1229475at2759
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	1	1.000	-	-		otm40394
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23110
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	6.020