DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment chinmo and mamo

DIOPT Version :9

Sequence 1:	NP_001188680.1	Gene:	chinmo / 33343	FlyBaseID:	FBgn0086758	Length:	840	Species:	Drosophila melanogaster
Sequence 2:	NP_572932.2	Gene:	mamo / 32353	FlyBaseID:	FBgn0267033	Length:	1553	Species:	Drosophila melanogaster

Alignment Length:	1001	Identity:	215/1001 - (21%)
Similarity:	329/1001 - (32%)	Gaps:	367/1001 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 QQFCLKWNSFSSNLAITFSNLFKSDLLADVILSC-DGVVFKAHKLILAACSKKFADLFENTPTNG 68
            :.:||:||::.|||...||.|.:...|.||.|.| :|...:|||::|:|||..|..||...| .|
  Fly     4 EHYCLRWNNYQSNLLGVFSQLLQDGSLVDVTLVCSEGTSIRAHKVVLSACSSYFQSLFLEHP-EG 67

  Fly    69 QCVIILEATTPDNMAALLEFMYKGEVHVSQEALNSFLKSAESLQVKGLSTETGRLAAQQAQQHMG 133
            ..::||:......:..|:||||||||:|....|::.||:||||:||||        |:...|:..
  Fly    68 HLIVILKDVRFAELQTLVEFMYKGEVNVQYCQLSALLKTAESLKVKGL--------AEMTNQNTT 124

  Fly   134 DLSPLDSPTGRRSVRNSLSGGSSSIVPGGVGIGLGGGATGANSMSGMGIGNGLSLAGMAAGGGMA 198
            ...|...|...|              |.|.| |.||.|..|.......:.   :.|...|....|
  Fly   125 LREPEREPDRLR--------------PQGGG-GSGGSAHKAADSPAAALD---ATAATQAATATA 171

  Fly   199 AAANAAASSLSTLAASANIVDRCGSAGANIISGSAAGIGGSHSGGAGNGSGTVGIGGNGVGSGGG 263
            .|..|||:|.||.|.||  .....:..|...|.:|....||.:......:.|.........|...
  Fly   172 TATAAAATSTSTSATSA--AATAAATAATSASTTATAAAGSSNTTTTTAATTTATCATAATSTAA 234

  Fly   264 NNGPISLGSGAGAAHHLGGSTGILKQECDSLMHPGGSSSSSG------MGYTHVPPIYRPINYEP 322
            .:...|:.|.|.||.....::|:...|     ....||||:|      ...:...|..|.....|
  Fly   235 TSSSSSVTSAAAAAAAAASASGVAHSE-----EATSSSSSTGGQKREASDRSSPTPAKRSSRMHP 294

  Fly   323 PRKRAIVRSPYSEQEQRGSVLR-----------------------------------DGSKSSEC 352
            ..|..:......||.|...:|.                                   |..:..:.
  Fly   295 ADKVDVAEDREQEQNQADELLSEELLGRNLKDEEDDDVDELDENEETKLRGRDEDDDDEDEEEDT 359

  Fly   353 PSPIN--KPPYHRPSSSASSTAPTE---------ADTMHSERASPQSSRYENHSPSTTAGNGNAT 406
            |.|::  :.|...|.|:|::||..:         ::..|: .:|..|:...|::.::::.|.|.|
  Fly   360 PMPLDLYQRPNVEPKSAAAATAAQQGGSNSLSGSSNACHT-NSSSNSNNNNNNNNNSSSNNNNNT 423

  Fly   407 SSLERIVKSERNNGSA-------------NEANDDD------RELMDESTDNGAEDLRVKLENLK 452
            ||.:....|  |.|:|             ::.:|||      |::||:..:...::
  Fly   424 SSGKTSASS--NGGTASSGGTADSVVAVDDDDDDDDGGHHHQRQVMDDRLEQDVDE--------- 477

  Fly   453 YSPPPPPNSNTSSTTPNTLLENLKADGTLSSNLAASIAPADMLNVWNATKMNNKNSVNTADGKKL 517
                                |:|..|       ...:.||..:....|.::.::|
  Fly   478 --------------------EDLDDD-------VVVVGPATAMARGIAQRLAHQN---------- 505

  Fly   518 KCLYCDRLYGYETNLRAHIRQRHQGIRVPCPFCERTFTRNNTVRRH------------IAR---- 566
                ..||:      ..|...:||..:...|..:...|.::  ::|            ||:
  Fly   506 ----LQRLH------HTHHHAQHQHSQHHHPHSQHHHTPHH--QQHHTHSDDEDAMPVIAKSEIL 558

  Fly   567 ----------EHKQE------------------------IGLAAGATIAPAHLAAAAAASAAATA 597
                      |...|                        :.|:.|:|:.|:.|....::||||.|
  Fly   559 DDDYDDEMDLEDDDEADNSSNDLGLNMKMGSGGAGGGGGVDLSTGSTLIPSPLITLPSSSAAAAA 623

  Fly   598 AASNHSPXEAAATAAASVVMNANKEAAKQRKRKTLKMALEKCMQRRDAMVAETTTGAGGDGAEAG 662
            ||:                      ||.:.:|.|            .||.|....|||......|
  Fly   624 AAA----------------------AAMESQRST------------PAMSAAQAAGAGASDLSIG 654

  Fly   663 GESGEAV-----DGAGSEEGAG--------SEGT---------EPLTYEQQ-------------- 691
            |..|...     ||.|::.|.|        |.||         .||:.:::
  Fly   655 GCGGRPASRSSRDGGGNDGGRGGASSSSLLSPGTVANLLPVQSVPLSLKKEIDCSEDDNSSHSRH 719

  Fly   692 -QQR----------------MHQELTQQI---RAAMAAEQ------------------------- 711
             |||                .|:.|.:..   .:||||.:
  Fly   720 MQQRSASAGGGLGGDLDYRASHESLLRNFSSPMSAMAASRCPTPFAFPFSPLGLSLFDIDPSRIL 784

  Fly   712 ---------AAEAMDST-----------MNTTVNTTTT------------TTTTTNTTGATSDGC 744
                     |.||:.:.           ..||::...|            |.|.|.||.:::
  Fly   785 SLLHHQTWLAEEALRTRGLLTAPKDFPHRFTTLSDLLTKDYQPGAGQPMVTATATATTASST--- 846

  Fly   745 SDAEASDGSDRPMEVDEDQPPEPQPG 770
            |...||...|........||.:||.|
  Fly   847 SQVSASRSGDTQYNKHAQQPQQPQTG 872

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
chinmo	NP_001188680.1	BTB	22..116	CDD:279045	42/94 (45%)
		BTB	33..116	CDD:197585	38/83 (46%)
		C2H2 Zn finger	519..540	CDD:275368	3/20 (15%)
		C2H2 Zn finger	547..568	CDD:275368	5/46 (11%)
mamo	NP_572932.2	BTB	21..118	CDD:279045	45/105 (43%)
		BTB	32..118	CDD:197585	41/94 (44%)
		C2H2 Zn finger	1082..1105	CDD:275368
		C2H2 Zn finger	1116..1137	CDD:275368
		C2H2 Zn finger	1149..1169	CDD:275368
		zf-C2H2	1469..1491	CDD:278523
		C2H2 Zn finger	1471..1491	CDD:275368
		zf-H2C2_2	1483..1506	CDD:290200
		C2H2 Zn finger	1499..1519	CDD:275368
		zf-H2C2_2	1511..1536	CDD:290200
		C2H2 Zn finger	1527..1547	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	68	1.000	Domainoid score	I9675
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23110
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	4.010