DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment haf and SLIT2

DIOPT Version :9

Sequence 1:	NP_001356954.1	Gene:	haf / 33339	FlyBaseID:	FBgn0261509	Length:	1347	Species:	Drosophila melanogaster
Sequence 2:	XP_005248268.1	Gene:	SLIT2 / 9353	HGNCID:	11086	Length:	1533	Species:	Homo sapiens

Alignment Length:	503	Identity:	127/503 - (25%)
Similarity:	192/503 - (38%)	Gaps:	136/503 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 AHAQCPWQRDVPDLQTSCICAYNLGRELSVQCDQVDFSQLLAAMNTHARLKPVDLLYVNNS-TIS 94
            |...||         ..|.|     ...:|.|.    :|.|..:..|......:|...||. |:.
Human   506 ADLACP---------EKCRC-----EGTTVDCS----NQKLNKIPEHIPQYTAELRLNNNEFTVL 552

  Fly    95 ELPDAVFSNL-SLHNLQLSSCGIQRIATGAFKGQESVLRNLNLQDNLLADVPVEALKVLGKLNLL 158
            | ...:|..| .|..:..|:..|..|..|||:|...| ..:.|..|.|.:|..:..|.|..|..|
Human   553 E-ATGIFKKLPQLRKINFSNNKITDIEEGAFEGASGV-NEILLTSNRLENVQHKMFKGLESLKTL 615

  Fly   159 DLSKNQLSHIPDDAFVGLTKLSTLKLNDNNV-TLASNAFRGLEQSLKNLNLKGT----------- 211
            .|..|:::.:.:|:|:||:.:..|.|.||.: |:|..||..| .||..|||...
Human   616 MLRSNRITCVGNDSFIGLSSVRLLSLYDNQITTVAPGAFDTL-HSLSTLNLLANPFNCNCYLAWL 679

  Fly   212 -----KQRKVPESIR-----GLKSLAFLDL----------------------------------- 231
                 |:|.|..:.|     .||.:...|:
Human   680 GEWLRKKRIVTGNPRCQKPYFLKEIPIQDVAIQDFTCDDGNDDNSCSPLSRCPTECTCLDTVVRC 744

  Fly   232 SQNGIKELPGAGGIRVFDGLDA-LTALNLERNLIQSIGETAFAGVRKTLSS------LSLLNNLL 289
            |..|:|.||        .|:.. :|.|.|:.|        .|..|.|.||:      :.|.||.:
Human   745 SNKGLKVLP--------KGIPRDVTELYLDGN--------QFTLVPKELSNYKHLTLIDLSNNRI 793

  Fly   290 AEFPIGAVHSLKELRVLDIGFNLLTSLPEAAFRGNPGITLLALDGNPLSSVPEGAFAHLNATLRG 354
            :.....:..::.:|..|.:.:|.|..:|...|.|...:.||:|.||.:|.||||||..|:| |..
Human   794 STLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVVPEGAFNDLSA-LSH 857

  Fly   355 LSLGGRFLHCDCKLRWVAEWIRNGDLQVTSRERNPQF--CGTPPRFRDRGFYSIQPEELSCPDIA 417
            |::|...|:|||.::|:::|::       |..:.|..  |..|....|:...:...::.:|
Human   858 LAIGANPLYCDCNMQWLSDWVK-------SEYKEPGIARCAGPGEMADKLLLTTPSKKFTC---- 911

  Fly   418 DAALRGP--VGLADNLKPTLPSSPDSVEYETGTGTGTVGTGTAASAPV 463
                :||  |.:.....|.| |:|            ....||..|.||
Human   912 ----QGPVDVNILAKCNPCL-SNP------------CKNDGTCNSDPV 942

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
haf	NP_001356954.1	LRR	<52..>252	CDD:227223	62/258 (24%)
		leucine-rich repeat	86..105	CDD:275380	6/20 (30%)
		leucine-rich repeat	106..129	CDD:275380	8/22 (36%)
		LRR_8	131..189	CDD:338972	18/57 (32%)
		leucine-rich repeat	131..154	CDD:275380	6/22 (27%)
		leucine-rich repeat	155..178	CDD:275380	8/22 (36%)
		leucine-rich repeat	179..202	CDD:275380	9/23 (39%)
		leucine-rich repeat	203..225	CDD:275380	9/42 (21%)
		leucine-rich repeat	226..253	CDD:275380	7/61 (11%)
		LRR_8	254..337	CDD:338972	24/88 (27%)
		leucine-rich repeat	254..302	CDD:275380	12/53 (23%)
		leucine-rich repeat	303..326	CDD:275380	7/22 (32%)
		leucine-rich repeat	327..350	CDD:275380	13/22 (59%)
		PCC	332..>413	CDD:188093	26/82 (32%)
		PRK10927	<1061..>1097	CDD:236797
SLIT2	XP_005248268.1	LRRNT	27..58	CDD:214470
		leucine-rich repeat	38..56	CDD:275380
		LRR_8	55..115	CDD:404697
		leucine-rich repeat	57..80	CDD:275380
		internalin_A	73..>434	CDD:380193
		leucine-rich repeat	81..104	CDD:275380
		leucine-rich repeat	105..128	CDD:275380
		leucine-rich repeat	129..152	CDD:275380
		leucine-rich repeat	153..176	CDD:275380
		LRR_8	154..211	CDD:404697
		leucine-rich repeat	177..200	CDD:275380
		leucine-rich repeat	201..329	CDD:275380
		LRR_8	307..364	CDD:404697
		leucine-rich repeat	330..353	CDD:275380
		leucine-rich repeat	354..374	CDD:275380
		leucine-rich repeat	378..401	CDD:275380
		leucine-rich repeat	402..423	CDD:275380
		PCC	407..>470	CDD:188093
		leucine-rich repeat	426..527	CDD:275380	7/38 (18%)
		LRRNT	509..539	CDD:214470	9/47 (19%)
		leucine-rich repeat	541..563	CDD:275380	7/22 (32%)
		internalin_A	561..>858	CDD:380193	85/315 (27%)
		leucine-rich repeat	564..587	CDD:275380	8/22 (36%)
		leucine-rich repeat	588..611	CDD:275380	7/23 (30%)
		leucine-rich repeat	612..635	CDD:275380	8/22 (36%)
		leucine-rich repeat	636..659	CDD:275380	9/23 (39%)
		leucine-rich repeat	660..751	CDD:275380	13/90 (14%)
		leucine-rich repeat	752..782	CDD:275380	12/45 (27%)
		LRR_8	782..841	CDD:404697	15/58 (26%)
		leucine-rich repeat	783..806	CDD:275380	3/22 (14%)
		leucine-rich repeat	807..830	CDD:275380	7/22 (32%)
		leucine-rich repeat	831..852	CDD:275380	12/20 (60%)
		PCC	836..>1017	CDD:188093	39/136 (29%)
		leucine-rich repeat	855..867	CDD:275378	4/11 (36%)
		EGF_CA	1002..1038	CDD:238011
		EGF_CA	1042..1077	CDD:238011
		EGF_CA	1080..1116	CDD:238011
		hEGF	1134..1155	CDD:403759
		LamG	1187..1320	CDD:214598
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910