DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment haf and Lrrc15

DIOPT Version :9

Sequence 1:	NP_001356954.1	Gene:	haf / 33339	FlyBaseID:	FBgn0261509	Length:	1347	Species:	Drosophila melanogaster
Sequence 2:	NP_083249.1	Gene:	Lrrc15 / 74488	MGIID:	1921738	Length:	579	Species:	Mus musculus

Alignment Length:	504	Identity:	134/504 - (26%)
Similarity:	199/504 - (39%)	Gaps:	71/504 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRPGRTTTALPAATTPLLLLLPLILGRLHVAHAQCPWQRDVPDLQTSCICAYNLGRELSVQCDQV 65
            |........:|.|...|..|..|.|....:.:......:||.:|:|..:....|     ||....
Mouse    84 MEKNELANIMPGAFRNLGSLRHLSLANNKLKNLPVRLFQDVNNLETLLLSNNQL-----VQIQPA 143

  Fly    66 DFSQLLAAMNTHARLKPVDLLYVNNSTISELPDAVFSNL-SLHNLQLSSCGIQRIATGAFK--GQ 127
            .|||.       :.||.:. ||.||  :..:|:.||.:| .|..|.|.:.|...::...|:  |.
Mouse   144 QFSQF-------SNLKELQ-LYGNN--LEYIPEGVFDHLVGLTKLNLGNNGFTHLSPRVFQHLGN 198

  Fly   128 ESVLRNLNLQDNLLADVPVEALKVLGKLNLLDLSKNQLSHIPDDAFVGLTKLSTLKLNDNNVT-L 191
            ..|||   |.:|.|:|:|:.....||.|..|.|.:||:..:....|.....|..|.|::|::: |
Mouse   199 LQVLR---LYENRLSDIPMGTFDALGNLQELALQENQIGTLSPGLFHNNRNLQRLYLSNNHISHL 260

  Fly   192 ASNAFRGLEQSLKNLNLKGTKQRKVPESIRG-LKSLAFLDLSQNGIKELPGAGGIRVFDGLDALT 255
            ....|..|.. |..|.|.|...:::...:.| :.:|..|.|..|.|..||.    ..|..|:.|.
Mouse   261 PPGIFMQLPH-LNKLTLFGNSLKELSPGVFGPMPNLRELWLYNNHITSLPD----NAFSHLNQLQ 320

  Fly   256 ALNLERNLIQSIGETAFAGVRKTLSSLSLLNNLLAEFPIGAVHSLKELRVLDIGFNLLTSLPEAA 320
            .|.|..|.:..|...||.|: ..|..|||..|.|.:.......||..||.:.:..|.|..||.:.
Mouse   321 VLILSHNQLSYISPGAFNGL-TNLRELSLHTNALQDLDGNVFRSLANLRNVSLQNNRLRQLPGSI 384

  Fly   321 FRGNPGITLLALDGNPLSSVPEGAFAHLNATLRGLSLGGRFLHCDCKLRWVAEWIRNGDLQVTSR 385
            |....|:..:.|..|.|.::|.|.|.|| ..|..|.|......||..:..:.:|:      :.:|
Mouse   385 FANVNGLMTIQLQNNNLENLPLGIFDHL-GNLCELRLYDNPWRCDSNILPLHDWL------ILNR 442

  Fly   386 ER----NPQFCGTPPRFRDRGFYSIQPEELSCPDIADAALRGPVGLADNLKPTLPSSPDSVEYET 446
            .|    ....|.:|...|.:....|.      .:....:::||.      .|.:.|.||:..|
Mouse   443 ARLGTDTLPVCSSPASVRGQSLVIIN------VNFPGPSVQGPE------TPEVSSYPDTSSY-- 493

  Fly   447 GTGTGTVGTGTAASAPVTSSVSSSTSTTTPTTT--TTTTTAEPTTRRST 493
                           |.::|:||:|..|..|..  |...|.||...|:|
Mouse   494 ---------------PDSTSISSTTEITRSTDDDYTDLNTIEPIDDRNT 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
haf	NP_001356954.1	LRR	<52..>252	CDD:227223	58/204 (28%)
		leucine-rich repeat	86..105	CDD:275380	8/19 (42%)
		leucine-rich repeat	106..129	CDD:275380	6/24 (25%)
		LRR_8	131..189	CDD:338972	19/57 (33%)
		leucine-rich repeat	131..154	CDD:275380	8/22 (36%)
		leucine-rich repeat	155..178	CDD:275380	6/22 (27%)
		leucine-rich repeat	179..202	CDD:275380	7/23 (30%)
		leucine-rich repeat	203..225	CDD:275380	5/22 (23%)
		leucine-rich repeat	226..253	CDD:275380	9/26 (35%)
		LRR_8	254..337	CDD:338972	26/82 (32%)
		leucine-rich repeat	254..302	CDD:275380	16/47 (34%)
		leucine-rich repeat	303..326	CDD:275380	7/22 (32%)
		leucine-rich repeat	327..350	CDD:275380	8/22 (36%)
		PCC	332..>413	CDD:188093	20/84 (24%)
		PRK10927	<1061..>1097	CDD:236797
Lrrc15	NP_083249.1	LRR 1	54..75
		leucine-rich repeat	58..78	CDD:275380
		LRR 2	78..99		3/14 (21%)
		PLN00113	82..>401	CDD:215061	96/340 (28%)
		LRR 3	102..123		3/20 (15%)
		leucine-rich repeat	103..126	CDD:275380	5/22 (23%)
		LRR 4	126..147		6/25 (24%)
		leucine-rich repeat	127..150	CDD:275380	8/34 (24%)
		LRR 5	150..171		9/23 (39%)
		leucine-rich repeat	151..174	CDD:275380	10/25 (40%)
		LRR 6	174..195		5/20 (25%)
		leucine-rich repeat	175..198	CDD:275380	5/22 (23%)
		LRR 7	198..219		8/23 (35%)
		leucine-rich repeat	199..222	CDD:275380	9/25 (36%)
		LRR 8	222..243		6/20 (30%)
		leucine-rich repeat	223..246	CDD:275380	6/22 (27%)
		LRR 9	246..267		6/20 (30%)
		leucine-rich repeat	247..270	CDD:275380	7/22 (32%)
		LRR 10	270..291		4/21 (19%)
		leucine-rich repeat	271..294	CDD:275380	5/22 (23%)
		LRR 11	294..315		8/24 (33%)
		leucine-rich repeat	295..318	CDD:275380	9/26 (35%)
		LRR 12	318..339		7/20 (35%)
		leucine-rich repeat	319..342	CDD:275380	8/23 (35%)
		LRR 13	342..363		6/20 (30%)
		leucine-rich repeat	343..364	CDD:275380	6/20 (30%)
		LRR 14	366..387		7/20 (35%)
		leucine-rich repeat	367..387	CDD:275380	7/19 (37%)
		LRR 15	390..411		7/20 (35%)
		leucine-rich repeat	391..412	CDD:275380	6/20 (30%)
		LRRCT	423..>462	CDD:214507	8/44 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	476..509		13/55 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910