DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment haf and Cpn2

DIOPT Version :9

Sequence 1:NP_001356954.1 Gene:haf / 33339 FlyBaseID:FBgn0261509 Length:1347 Species:Drosophila melanogaster
Sequence 2:NP_082180.2 Gene:Cpn2 / 71756 MGIID:1919006 Length:547 Species:Mus musculus


Alignment Length:381 Identity:114/381 - (29%)
Similarity:177/381 - (46%) Gaps:55/381 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    74 MNTHAR-LKP--------VDLLYVNNSTISELPDAVFSNLS------------------------ 105
            :||..| |:|        :..|.:..|.:|.|...:|||||                        
Mouse    81 LNTQVRHLEPDAFGGLPRLQDLEITGSPVSNLSAHIFSNLSSLEKLTLDFDRLAGLPEDLFCHMD 145

  Fly   106 -LHNLQLSSCGIQRIATGAFKGQESVLRNLNLQDNLLADVPVEALKVLGKLNLLDLSKNQLSHIP 169
             |.:|||....::.:....|:.... ||.|||..|||..:|..|.:.|..|.:|.||.|.|:.:|
Mouse   146 ILESLQLQGNQLRTLPGRLFQSLRD-LRTLNLAQNLLTQLPKGAFQSLTGLQMLKLSNNMLARLP 209

  Fly   170 DDAFVGLTKLSTLKLNDNNVT-LASNAFRGLEQSLKNLNLKGTKQRKVPESI-RGLKSLAFLDLS 232
            :.|...|:.|..|.|:.|.:| |:.:.|..| .||:.|.|:......:|.|: ..|.:|.||.|.
Mouse   210 EGALGSLSSLQELFLDGNAITELSPHLFSQL-FSLEMLWLQHNAICHLPVSLFSSLHNLTFLSLK 273

  Fly   233 QNGIKELPGAGGIRVFDGLDA----LTALNLERNLIQSIGETAFAGVRKTLSSLSLLNNLLAEFP 293
            .|.::.||        :||.|    |..|:|..|.:::|.|.||..:.: |.||:|.:|.:.:.|
Mouse   274 DNALRTLP--------EGLFAHNQGLLHLSLSYNQLETIPEGAFTNLSR-LVSLTLSHNAITDLP 329

  Fly   294 IGAVHSLKELRVLDIGFNLLTSLPEAAFRGNPGITLLALDGNPLSSVPEGAFAHLNATLRGLSLG 358
            .....:|::|..|.:..|.||:|..|.|.....:.||.|..|.|:::|.|.| ..|..|..|:|.
Mouse   330 EHVFRNLEQLVKLSLDSNNLTALHPALFHNLSRLQLLNLSRNQLTTLPGGIF-DTNYDLFNLALL 393

  Fly   359 GRFLHCDCKLRWVAEWIRNGDLQVTSRERNPQFCGTPPRFRDRGFYSIQPEELSCP 414
            |....|||.|.::..|:|..:.|:::..   .||..|...:.:...:::.|:|.||
Mouse   394 GNPWQCDCHLSYLTSWLRLYNNQISNTH---TFCAGPAYLKGQLVPNLKQEQLICP 446

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
hafNP_001356954.1 LRR <52..>252 CDD:227223 62/213 (29%)
leucine-rich repeat 86..105 CDD:275380 7/18 (39%)
leucine-rich repeat 106..129 CDD:275380 5/22 (23%)
LRR_8 131..189 CDD:338972 24/57 (42%)
leucine-rich repeat 131..154 CDD:275380 11/22 (50%)
leucine-rich repeat 155..178 CDD:275380 9/22 (41%)
leucine-rich repeat 179..202 CDD:275380 8/23 (35%)
leucine-rich repeat 203..225 CDD:275380 6/22 (27%)
leucine-rich repeat 226..253 CDD:275380 9/26 (35%)
LRR_8 254..337 CDD:338972 27/82 (33%)
leucine-rich repeat 254..302 CDD:275380 15/47 (32%)
leucine-rich repeat 303..326 CDD:275380 8/22 (36%)
leucine-rich repeat 327..350 CDD:275380 8/22 (36%)
PCC 332..>413 CDD:188093 23/80 (29%)
PRK10927 <1061..>1097 CDD:236797
Cpn2NP_082180.2 LRRNT 21..52 CDD:214470
LRR_8 73..133 CDD:290566 14/51 (27%)
leucine-rich repeat 75..98 CDD:275380 5/16 (31%)
LRR 1 98..119 5/20 (25%)
leucine-rich repeat 99..122 CDD:275380 8/22 (36%)
LRR_8 121..181 CDD:290566 12/60 (20%)
LRR 2 122..143 0/20 (0%)
leucine-rich repeat 123..146 CDD:275380 0/22 (0%)
LRR 3 146..167 5/20 (25%)
leucine-rich repeat 147..170 CDD:275380 5/22 (23%)
LRR_RI 149..374 CDD:238064 76/235 (32%)
LRR 4 170..191 10/21 (48%)
LRR_8 171..229 CDD:290566 24/57 (42%)
leucine-rich repeat 171..194 CDD:275380 11/22 (50%)
LRR 5 194..215 8/20 (40%)
leucine-rich repeat 195..218 CDD:275380 9/22 (41%)
LRR_8 217..277 CDD:290566 20/60 (33%)
LRR 6 218..239 7/20 (35%)
leucine-rich repeat 219..242 CDD:275380 8/23 (35%)
LRR 7 242..263 6/20 (30%)
leucine-rich repeat 243..266 CDD:275380 6/22 (27%)
LRR_8 266..325 CDD:290566 23/67 (34%)
LRR 8 266..287 9/28 (32%)
leucine-rich repeat 267..290 CDD:275380 10/30 (33%)
LRR 9 290..311 8/20 (40%)
leucine-rich repeat 291..314 CDD:275380 8/22 (36%)
LRR_8 313..373 CDD:290566 19/60 (32%)
LRR 10 314..335 6/21 (29%)
leucine-rich repeat 315..338 CDD:275380 7/22 (32%)
LRR 11 338..359 8/20 (40%)
leucine-rich repeat 339..360 CDD:275380 8/20 (40%)
LRR 12 362..383 8/21 (38%)
leucine-rich repeat 363..382 CDD:275380 8/19 (42%)
LRRCT 395..436 CDD:214507 10/43 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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