DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment haf and Lrrtm2

DIOPT Version :9

Sequence 1:	NP_001356954.1	Gene:	haf / 33339	FlyBaseID:	FBgn0261509	Length:	1347	Species:	Drosophila melanogaster
Sequence 2:	NP_001102939.1	Gene:	Lrrtm2 / 685472	RGDID:	1593785	Length:	515	Species:	Rattus norvegicus

Alignment Length:	490	Identity:	121/490 - (24%)
Similarity:	190/490 - (38%)	Gaps:	104/490 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LPAATTPLLLLLPLILGRLHVAHAQCPWQRDVPDLQTSCICAYNLGRELSVQCDQVDFSQLLAAM 74
            |.|.....:..:.::|..|......||         ..|.|     .:|...||...|
  Rat     9 LGAPMLAAIYAMSVVLKMLPALGMACP---------PKCRC-----EKLLFYCDSQGF------- 52

  Fly    75 NTHARLKPVDLLYVNNSTISELPDAVFSNLSLHNLQLSSCGIQRIATGAFKGQESVLRNLNLQDN 139
              |:         |.|:|     |.....|||.:..:::  ::|....:|    |.|..|:|..|
  Rat    53 --HS---------VPNAT-----DKGSLGLSLRHNHITA--LERDQFASF----SQLTWLHLDHN 95

  Fly   140 LLADVPVEALKVLGKLNLLDLSKNQLSHIPDDAFVGLTKLSTLKLNDNNV-TLASNAFRGLEQSL 203
            .::.|..:|.:.|.||..|.||.|::.::|:..|..|..|..|.|:.|.: :|....|.|| :.|
  Rat    96 QISTVKEDAFQGLYKLKELILSSNKIFYLPNTTFTQLINLQNLDLSFNQLSSLHPELFYGL-RKL 159

  Fly   204 KNLNLKGTKQRKVPESIR---GLKSLAFLDLSQNGIKELPGAGGIRVFDGLDALTALNLERNLIQ 265
            :.|:|:....|.:|  :|   ..:||.|||||.|.::.|...|    |.||..|..|:||.|.:.
  Rat   160 QTLHLRSNSLRTIP--VRLFWDCRSLEFLDLSTNRLRSLARNG----FAGLIKLRELHLEHNQLT 218

  Fly   266 SIGETAFAGVRKTLSSLSLLNNLLAEFPIGAVHSLKELRVLDIGFNLLTSLPEAAFRGNPGITLL 330
            .|....|..: .:|.:|.|..|.::....|...:...|..||:..|.:.::....|...|.:.:|
  Rat   219 KINFAHFLRL-SSLHTLFLQWNKISNLTCGMEWTWSTLEKLDLTGNEIKAIDLTVFETMPNLKIL 282

  Fly   331 ALDGNPLSSVPEGAFAHLNATLRGLSLGGRFLHCDCKLRWVAEWIRNGDLQVTSRERNPQFCGTP 395
            .:|.|.|:|:.....:.|. :|..:.|.|....|..::..:|.|:.:
  Rat   283 LMDNNKLNSLDSKILSSLR-SLTTVGLSGNLWECSPRVCALASWLGS------------------ 328

  Fly   396 PRFRDRGFYSI---QPEELSCPDIADAALRGPVGLADNLKPTLPSSPDSVEYETGTGTGTVGTGT 457
              |:.|..:||   .|:.....||.| |:.| ..|..||..|:                 ....|
  Rat   329 --FQGRWEHSILCHSPDHTQGEDILD-AVHG-FQLCWNLSTTV-----------------TAMAT 372

  Fly   458 AASAPVT--SSVSSST----STTTPTTTTTTTTAE 486
            ....|.|  :.:|||:    ....|||.....|.|
  Rat   373 TYRDPTTEYTKISSSSYHVGDKEIPTTAGIAVTTE 407

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
haf	NP_001356954.1	LRR	<52..>252	CDD:227223	57/203 (28%)
		leucine-rich repeat	86..105	CDD:275380	4/18 (22%)
		leucine-rich repeat	106..129	CDD:275380	3/22 (14%)
		LRR_8	131..189	CDD:338972	20/57 (35%)
		leucine-rich repeat	131..154	CDD:275380	7/22 (32%)
		leucine-rich repeat	155..178	CDD:275380	8/22 (36%)
		leucine-rich repeat	179..202	CDD:275380	8/23 (35%)
		leucine-rich repeat	203..225	CDD:275380	6/24 (25%)
		leucine-rich repeat	226..253	CDD:275380	12/26 (46%)
		LRR_8	254..337	CDD:338972	21/82 (26%)
		leucine-rich repeat	254..302	CDD:275380	12/47 (26%)
		leucine-rich repeat	303..326	CDD:275380	5/22 (23%)
		leucine-rich repeat	327..350	CDD:275380	6/22 (27%)
		PCC	332..>413	CDD:188093	16/83 (19%)
		PRK10927	<1061..>1097	CDD:236797
Lrrtm2	NP_001102939.1	LRR 1	61..83		4/23 (17%)
		leucine-rich repeat	66..86	CDD:275380	5/25 (20%)
		LRR_RI	73..311	CDD:238064	72/252 (29%)
		LRR 2	84..107		8/26 (31%)
		LRR_8	85..145	CDD:290566	21/59 (36%)
		leucine-rich repeat	87..110	CDD:275380	7/22 (32%)
		LRR 3	109..131		8/21 (38%)
		leucine-rich repeat	111..134	CDD:275380	8/22 (36%)
		LRR 4	132..155		7/22 (32%)
		LRR_8	134..193	CDD:290566	22/61 (36%)
		leucine-rich repeat	135..158	CDD:275380	8/23 (35%)
		LRR 5	156..179		7/25 (28%)
		leucine-rich repeat	159..182	CDD:275380	6/24 (25%)
		LRR_8	181..241	CDD:290566	24/64 (38%)
		LRR 6	181..203		11/25 (44%)
		leucine-rich repeat	183..206	CDD:275380	12/26 (46%)
		LRR 7	205..227		7/21 (33%)
		leucine-rich repeat	207..230	CDD:275380	7/23 (30%)
		LRR 8	229..251		5/21 (24%)
		leucine-rich repeat	231..254	CDD:275380	5/22 (23%)
		LRR 9	252..275		5/22 (23%)
		LRR_8	253..312	CDD:290566	15/59 (25%)
		leucine-rich repeat	255..278	CDD:275380	5/22 (23%)
		LRR 10	276..299		6/22 (27%)
		leucine-rich repeat	279..300	CDD:275380	5/20 (25%)
		Involved in DLG4-binding	512..515
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910