DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment haf and Vasn

DIOPT Version :9

Sequence 1:	NP_001356954.1	Gene:	haf / 33339	FlyBaseID:	FBgn0261509	Length:	1347	Species:	Drosophila melanogaster
Sequence 2:	NP_001102852.1	Gene:	Vasn / 679921	RGDID:	1598149	Length:	673	Species:	Rattus norvegicus

Alignment Length:	844	Identity:	192/844 - (22%)
Similarity:	281/844 - (33%)	Gaps:	284/844 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 TALPAATTPLLLLLPLILGRLHVAHAQCPWQRDVPDLQTSCICAYNLGRELSVQCDQVDFSQLLA 72
            :.||    ||||||.::||.   ....||         :.|            ||:|.......|
  Rat     5 SCLP----PLLLLLLVLLGS---GVQSCP---------SGC------------QCNQPQTVFCTA 41

  Fly    73 AMNTHA-RLKPVDL--LYVNNSTISELPDAVFSNL-SLHNLQLSSCGIQRIATGAFKGQESVLRN 133
            ...|.. |..|.|.  ||:..:.|:.|....|:.. .|..|.||...|..:..|.|:...: |.|
  Rat    42 RQGTTVPRDVPPDTVGLYIFENGITTLDVGCFAGFPGLQLLDLSQNQITSLPGGIFQPLVN-LSN 105

  Fly   134 LNLQDNLLADVPVEALKVLGKLNLLDLSKNQLSHIPDDAFVGLTKLSTLKLNDNN---------- 188
            |:|..|.|.::..|..:.|.:|..|.|.||::.||...||..|..|..|||.||.
  Rat   106 LDLTANKLHEISNETFRGLRRLERLYLGKNRIRHIQPGAFDALDHLLELKLPDNELRVLPPLHLP 170

  Fly   189 ----VTLASNAFRGLE------QSLKNLNLKGTKQRKVPESIRG-LKSLAFLDLSQNGIKELPGA 242
                :.|:.|:...||      .:::.|.|.|...|::.|.:.| |::|..||:|.|.:..:|.
  Rat   171 RLLLLDLSHNSIPALEAGILDTANVEALRLAGLGLRQLDEGLFGRLRNLHDLDVSDNQLGHMPS- 234

  Fly   243 GGIRVFDGLDALTALNLERNLIQSIGETAFAGVR-KTLSSLSLLNNLLAEFPIGAVHSLKELRVL 306
                |..||..||.|.|       .|.|..|.:| :.|:.|:               :|:||.|.
  Rat   235 ----VIQGLRGLTRLRL-------AGNTRIAQIRPEDLAGLT---------------ALQELDVS 273

  Fly   307 DIGFNLLTSLPEAAFRGNPGITLLALDGNPLSSVPEGAFAHLNATLRGLSLGGRFLHCDCKLRWV 371
            ::....|.|...:.|   |.:.|||...||                         .:|.|.|.|.
  Rat   274 NLSLQALPSDLSSLF---PRLRLLAAARNP-------------------------FNCLCPLSWF 310

  Fly   372 AEWIRNGDLQVTSRERNPQFCGTPPRFRDRGFYSIQPEELSCPDIADAALRGPVGLADNLKPTLP 436
            ..|:|...:.:.|.|...  |..||:...|....:...:..||
  Rat   311 GPWVRESHVVLASPEETR--CHFPPKNAGRLLLELDYADFGCP---------------------- 351

  Fly   437 SSPDSVEYETGTGTGTVGTGTAASAPVTSSVSSSTSTTTPTTTTTTTTAEPTTRRSTTRPPTKST 501
                                                       .|||||...|.|.|.|.||.||
  Rat   352 -------------------------------------------VTTTTATVPTIRPTVREPTPST 373

  Fly   502 TTISATTASPASNPPVNGTGTVQATSITTSSSSSSSSSTSTGHGNGKQAPGWRQGVTNGNGNSGV 566
            ::.:.|..|| :.|      |.||..:.     |::..|.......:..|.   .:....|:..|
  Rat   374 SSQAPTWPSP-TEP------TTQAPIVL-----STAPPTMRPAPQPQDCPA---SICLNGGSCRV 423

  Fly   567 G-----------GAGGLH---------KPQ------RPPLVLGYPPQRGTRIDDANEVQVKHAFR 605
            |           |..||:         ||.      |||.:|      ..||:..:...::...:
  Rat   424 GAKHHLECLCPEGFIGLYCESPVEQRTKPSSIPDTPRPPRLL------PLRIEPVSPTSLRVELQ 482

  Fly   606 QDSSVIIQWDSDTANILGFRVVYRLFGEKAFKQGPP-------LESSEREFKIKNVPAQECIIVC 663
            :      ....:|..:...|:.||..      .||.       |.:|..|:.:..:.......:|
  Rat   483 R------YLQGNTVQLRSLRLTYRNL------SGPDKRLVTLRLPASLAEYTVTQLRPNATYSIC 535

  Fly   664 VISLEELHVTPETVPYQQCREVRTVASQASNMDKITIAASA----AICGTIIVAVIVFIAAS--- 721
            |.:|.... |||  ..:.|.|..|..:..||...:|.|...    .|...:...::..:|||
  Rat   536 VTALGAGR-TPE--GEEACGEANTPQAVRSNHAPVTQAREGNLPLLIAPALAAVLLAVLAASGAV 597

  Fly   722 ---RRSRKLQSSQQK-------SPLPIGGLPV--------------------NCCGP-TGSPGP 754
               ||:|...::|.|       .||.:.|:.|                    .|..| .|.|||
  Rat   598 YCVRRARASSTAQDKGQVGPGTGPLELEGVKVPLEPGSKASEGGGEALSGGPECEVPLMGYPGP 661

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
haf	NP_001356954.1	LRR	<52..>252	CDD:227223	63/224 (28%)
		leucine-rich repeat	86..105	CDD:275380	5/19 (26%)
		leucine-rich repeat	106..129	CDD:275380	7/22 (32%)
		LRR_8	131..189	CDD:338972	24/71 (34%)
		leucine-rich repeat	131..154	CDD:275380	8/22 (36%)
		leucine-rich repeat	155..178	CDD:275380	10/22 (45%)
		leucine-rich repeat	179..202	CDD:275380	10/42 (24%)
		leucine-rich repeat	203..225	CDD:275380	7/22 (32%)
		leucine-rich repeat	226..253	CDD:275380	9/26 (35%)
		LRR_8	254..337	CDD:338972	22/83 (27%)
		leucine-rich repeat	254..302	CDD:275380	11/48 (23%)
		leucine-rich repeat	303..326	CDD:275380	5/22 (23%)
		leucine-rich repeat	327..350	CDD:275380	5/22 (23%)
		PCC	332..>413	CDD:188093	14/80 (18%)
		PRK10927	<1061..>1097	CDD:236797
Vasn	NP_001102852.1	LRRNT	25..55	CDD:214470	10/50 (20%)
		leucine-rich repeat	35..57	CDD:275380	5/21 (24%)
		PPP1R42	58..257	CDD:411060	63/211 (30%)
		leucine-rich repeat	58..78	CDD:275380	5/19 (26%)
		leucine-rich repeat	79..102	CDD:275380	7/22 (32%)
		leucine-rich repeat	103..126	CDD:275380	8/22 (36%)
		leucine-rich repeat	127..150	CDD:275380	10/22 (45%)
		leucine-rich repeat	151..194	CDD:275380	10/42 (24%)
		leucine-rich repeat	195..218	CDD:275380	7/22 (32%)
		leucine-rich repeat	219..241	CDD:275380	9/26 (35%)
		leucine-rich repeat	242..266	CDD:275380	10/45 (22%)
		leucine-rich repeat	267..290	CDD:275380	7/25 (28%)
		PCC	271..>350	CDD:188093	22/108 (20%)
		EGF	410..441	CDD:394967	6/33 (18%)
		fn3	469..546	CDD:394996	14/89 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000