DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment haf and LGR6

DIOPT Version :9

Sequence 1:	NP_001356954.1	Gene:	haf / 33339	FlyBaseID:	FBgn0261509	Length:	1347	Species:	Drosophila melanogaster
Sequence 2:	NP_001017403.1	Gene:	LGR6 / 59352	HGNCID:	19719	Length:	967	Species:	Homo sapiens

Alignment Length:	470	Identity:	122/470 - (25%)
Similarity:	179/470 - (38%)	Gaps:	146/470 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 RPGRTTTALPAATTPLLLLLPLILGRLHVAHAQCPWQRDVPDLQTSCICAYNLGRELSVQCDQVD 66
            :||...||.|                     |.|..|.|...|...|       .||.:.....|
Human    27 QPGPGPTACP---------------------APCHCQEDGIMLSADC-------SELGLSAVPGD 63

  Fly    67 FSQLLA----AMNTHARLKP--------VDLLYVNNSTISELPDAVFSNL--------------- 104
            ...|.|    :||....|:|        ::.|.::.:.:|.:|...||.|
Human    64 LDPLTAYLDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGG 128

  Fly   105 ----------SLHNLQLSSCGIQRIATGAFKGQESVLRNLNLQDNLLADVPVEALKVLGKLNLLD 159
                      ||.:|:|.:..|..:...:|:|..| ||:|.|.||.|.::||.||..|..|..:.
Human   129 IPAEALWELPSLQSLRLDANLISLVPERSFEGLSS-LRHLWLDDNALTEIPVRALNNLPALQAMT 192

  Fly   160 LSKNQLSHIPDDAFVGLTKLSTLKLNDNNVT-LASNAFRGLEQSLKNLNLKGTKQRKVPESIRGL 223
            |:.|::|||||.||..||.|..|.|::|.:. |.:::|.|| .:|:.|:|...|.::.|.:||.|
Human   193 LALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGL-HNLETLDLNYNKLQEFPVAIRTL 256

  Fly   224 KSLAFLDLSQNGIKELPGAGGIRVFDGLDALTALNLERNLIQSIGETAF---------------- 272
            ..|..|....|.||.:|.    :.|.|...|..::...|.||.:|.:||
Human   257 GRLQELGFHNNNIKAIPE----KAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMD 317

  Fly   273 --------------------AGVR----------KTLSSLSLLNNLLAEFP----------IGAV 297
                                ||:|          ..|..|.|.:|.:.|.|          ||..
Human   318 IQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQ 382

  Fly   298 HS------------LKELRVLDIGFNLLTSLPEAAFRGNPGITLLALDGNPLSSVP---EGAFAH 347
            |:            |..|:.||:.:|.:.|:...||.....:..|.|..|.|:::|   .|...|
Human   383 HNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMH 447

  Fly   348 LNATLRG-LSLGGRF 361
            |.  |:| |:|...|
Human   448 LK--LKGNLALSQAF 460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
haf	NP_001356954.1	LRR	<52..>252	CDD:227223	71/237 (30%)
		leucine-rich repeat	86..105	CDD:275380	6/43 (14%)
		leucine-rich repeat	106..129	CDD:275380	6/22 (27%)
		LRR_8	131..189	CDD:338972	28/57 (49%)
		leucine-rich repeat	131..154	CDD:275380	12/22 (55%)
		leucine-rich repeat	155..178	CDD:275380	11/22 (50%)
		leucine-rich repeat	179..202	CDD:275380	8/23 (35%)
		leucine-rich repeat	203..225	CDD:275380	8/21 (38%)
		leucine-rich repeat	226..253	CDD:275380	8/26 (31%)
		LRR_8	254..337	CDD:338972	30/150 (20%)
		leucine-rich repeat	254..302	CDD:275380	20/115 (17%)
		leucine-rich repeat	303..326	CDD:275380	7/22 (32%)
		leucine-rich repeat	327..350	CDD:275380	8/25 (32%)
		PCC	332..>413	CDD:188093	12/34 (35%)
		PRK10927	<1061..>1097	CDD:236797
LGR6	NP_001017403.1	LRRNT	34..68	CDD:214470	11/61 (18%)
		LRR_RI	<57..199	CDD:238064	36/142 (25%)
		leucine-rich repeat	70..91	CDD:275380	4/20 (20%)
		LRR 1	91..112		4/20 (20%)
		LRR_8	92..150	CDD:290566	10/57 (18%)
		leucine-rich repeat	92..115	CDD:275380	6/22 (27%)
		LRR 2	115..136		0/20 (0%)
		leucine-rich repeat	116..139	CDD:275380	0/22 (0%)
		LRR_RI	131..392	CDD:238064	75/266 (28%)
		LRR 3	139..160		6/20 (30%)
		leucine-rich repeat	140..163	CDD:275380	6/22 (27%)
		LRR 4	163..186		12/23 (52%)
		leucine-rich repeat	164..187	CDD:275380	12/22 (55%)
		LRR_8	186..246	CDD:290566	23/60 (38%)
		LRR 5	187..208		10/20 (50%)
		leucine-rich repeat	188..211	CDD:275380	11/22 (50%)
		LRR 6	211..232		6/20 (30%)
		leucine-rich repeat	212..235	CDD:275380	8/23 (35%)
		LRR 7	235..256		7/20 (35%)
		leucine-rich repeat	236..258	CDD:275380	8/21 (38%)
		LRR_8	258..314	CDD:290566	15/59 (25%)
		LRR 8	258..279		7/24 (29%)
		leucine-rich repeat	259..282	CDD:275380	8/26 (31%)
		LRR 9	282..303		7/20 (35%)
		leucine-rich repeat	283..304	CDD:275380	7/20 (35%)
		LRR 10	306..328		0/21 (0%)
		LRR 11	329..350		3/20 (15%)
		leucine-rich repeat	330..344	CDD:275378	3/13 (23%)
		LRR 12	353..374		6/20 (30%)
		leucine-rich repeat	354..399	CDD:275380	10/44 (23%)
		LRR_8	375..434	CDD:290566	14/58 (24%)
		LRR 13	375..396		3/20 (15%)
		leucine-rich repeat	376..390	CDD:275378	3/13 (23%)
		LRR 14	399..420		7/20 (35%)
		leucine-rich repeat	400..423	CDD:275380	7/22 (32%)
		LRR 15	423..443		5/19 (26%)
		leucine-rich repeat	424..444	CDD:275380	5/19 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910