DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment haf and LOC563710

DIOPT Version :9

Sequence 1:	NP_001356954.1	Gene:	haf / 33339	FlyBaseID:	FBgn0261509	Length:	1347	Species:	Drosophila melanogaster
Sequence 2:	XP_692159.4	Gene:	LOC563710 / 563710	-ID:	-	Length:	635	Species:	Danio rerio

Alignment Length:	462	Identity:	109/462 - (23%)
Similarity:	183/462 - (39%)	Gaps:	116/462 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 LLYVNNSTISELPDAVFSNLSLHNLQLSSCGIQRIATGAFKGQESVLRNLNLQDNLLADVPVEAL 149
            ::|..:|...::|    .|||                |..:|       |:|:.|.||.:.....
Zfish    41 IVYCESSAFRDVP----KNLS----------------GGCQG-------LSLRYNSLASLKAGQF 78

  Fly   150 KVLGKLNLLDLSKNQLSHIPDDAFVGLTKLSTLKLNDNNVTLASNAFRGLEQSLKNLNLKGTK-Q 213
            ..|.:|..|.|..|.::::...||.|:.:|..|.|:.|.:||..|....|..:|:||:|...| |
Zfish    79 VGLNQLIWLYLDHNYIANVDARAFQGIRRLKELILSSNKITLLHNTTFHLVPNLRNLDLSYNKLQ 143

  Fly   214 RKVPESIRGLKSLAFLDLSQNGIKELPGAGGIRVFDGLDALTALNLERNLIQSIGETAFAGVRKT 278
            ...|...:||:.|..|.:..|.:|.||.    |:|.....|..|:|..|.::||...:.:|:.|
Zfish   144 ALQPGQFQGLRKLLSLHMRSNSLKNLPS----RLFQDCRNLEFLDLGYNRLRSITRNSMSGLLK- 203

  Fly   279 LSSLSLLNNLLAE-----FP-----------IGAVHSLKE--------LRVLDIGFNLLTSLPEA 319
            |:.|.:.:|..::     ||           ...:.::.|        |:.||:..|.|..:...
Zfish   204 LTELHIEHNQFSKINFFNFPRFYNLRALYLQWNRIRTMSEGLTWMWTSLQKLDLSGNDLQEIDAE 268

  Fly   320 AFRGNPGITLLALDGNPLSSVPEGAFAHLNA--TLRGLSLGGRFLHCDCKLRWVAEWIR--NGDL 380
            .:|..|.:..|.||.|.|.:|.:.|   ::|  :|..:||.|....|...:..:..|:|  .|:.
Zfish   269 VYRAMPNLQTLNLDSNKLVNVSQEA---VDAWTSLTAISLAGNMWDCGPVVCPLVAWMRTFRGNK 330

  Fly   381 QVTSRERNPQFCGTPPRFRDRGFYSIQPEELSCPDIADAALRGPVGLADNLKPTLPSSPDSVEYE 445
            ::.      ..|.:|.        .:|.|::.  |..||  .|...:|       |::|.::
Zfish   331 EIN------MICASPK--------EVQGEKVL--DAVDA--NGVCRIA-------PATPSTI--- 367

  Fly   446 TGTGTGTVGTGTAASAPVTSSVSSSTSTTTPTTTTTTTTAEPTTRRSTTRPPTKSTTTISATTAS 510
                          ..|.|..|:.|   .||.::...|.....:||       ...|::..:|:|
Zfish   368 --------------FVPSTPFVAFS---QTPASSLVPTLKSGDSRR-------VHGTSLEGSTSS 408

  Fly   511 PASNPPV 517
            ..|.|.|
Zfish   409 VPSQPDV 415

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
haf	NP_001356954.1	LRR	<52..>252	CDD:227223	46/167 (28%)
		leucine-rich repeat	86..105	CDD:275380	4/18 (22%)
		leucine-rich repeat	106..129	CDD:275380	2/22 (9%)
		LRR_8	131..189	CDD:338972	17/57 (30%)
		leucine-rich repeat	131..154	CDD:275380	6/22 (27%)
		leucine-rich repeat	155..178	CDD:275380	7/22 (32%)
		leucine-rich repeat	179..202	CDD:275380	8/22 (36%)
		leucine-rich repeat	203..225	CDD:275380	9/22 (41%)
		leucine-rich repeat	226..253	CDD:275380	8/26 (31%)
		LRR_8	254..337	CDD:338972	25/106 (24%)
		leucine-rich repeat	254..302	CDD:275380	13/63 (21%)
		leucine-rich repeat	303..326	CDD:275380	6/22 (27%)
		leucine-rich repeat	327..350	CDD:275380	7/22 (32%)
		PCC	332..>413	CDD:188093	19/84 (23%)
		PRK10927	<1061..>1097	CDD:236797
LOC563710	XP_692159.4	leucine-rich repeat	60..83	CDD:275380	7/29 (24%)
		LRR_RI	<81..286	CDD:238064	58/209 (28%)
		LRR_8	83..142	CDD:290566	19/58 (33%)
		leucine-rich repeat	84..107	CDD:275380	7/22 (32%)
		leucine-rich repeat	108..131	CDD:275380	8/22 (36%)
		LRR_8	130..190	CDD:290566	21/63 (33%)
		leucine-rich repeat	132..155	CDD:275380	9/22 (41%)
		leucine-rich repeat	156..179	CDD:275380	8/26 (31%)
		LRR_8	178..238	CDD:290566	13/60 (22%)
		leucine-rich repeat	180..203	CDD:275380	7/22 (32%)
		leucine-rich repeat	204..227	CDD:275380	5/22 (23%)
		leucine-rich repeat	228..251	CDD:275380	1/22 (5%)
		LRR_8	250..308	CDD:290566	18/60 (30%)
		leucine-rich repeat	252..275	CDD:275380	6/22 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24366
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100