DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment haf and lrig1

DIOPT Version :9

Sequence 1:	NP_001356954.1	Gene:	haf / 33339	FlyBaseID:	FBgn0261509	Length:	1347	Species:	Drosophila melanogaster
Sequence 2:	XP_688817.4	Gene:	lrig1 / 560325	ZFINID:	ZDB-GENE-031113-23	Length:	1022	Species:	Danio rerio

Alignment Length:	1125	Identity:	259/1125 - (23%)
Similarity:	391/1125 - (34%)	Gaps:	324/1125 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 LLLLPLILGRLHVAHAQCPW---------------QRDVP-DLQTSCICAYNLG----------- 55
            ||.|.|::.    ..|.||.               ..||| ||..|.: ..||.
Zfish    19 LLTLELLIN----YGAPCPQNCTCTLDTTDCSRLDMTDVPQDLPKSTV-HLNLSHNKLTAVDMDI 78

  Fly    56 -------RELSVQCDQV----DFSQLLAAMNT----HARLK-----------PVDLLYVNNSTIS 94
                   ||:.:..:::    .|....|::.|    |.|::           .::.|.::|:.|:
Zfish    79 LSNLPHLREVRLDHNELTSIPSFGDAAASVVTLLLHHNRIRRLEGSLLQNFSALETLDLSNNDIT 143

  Fly    95 ELPDAVFS-NLSLHNLQLSSCGIQRIATGAFKGQESVLRNLNLQDNLLADVPVEALKVLGKLNLL 158
            ||.:..|. .|.:.:|.|||..|..:..||||.....|:.|.|..|.|..:||:.|: |.||..|
Zfish   144 ELREHCFPLGLQIKDLHLSSNKIVHLEFGAFKNLAGSLQILRLSRNRLTHLPVKGLE-LPKLTQL 207

  Fly   159 DLSKNQLSHIPDDAFVGLTKLSTLKLNDNNVT-LASNAFRGLEQSLKNLNLKGTKQRKVPE-SIR 221
            :||:|:|..|....|.||:.|..|||..||:: |...||.||.: ::.|:|.....|:|.. |:.
Zfish   208 ELSRNRLRLIEGLTFQGLSSLEVLKLQRNNISKLTDGAFWGLAR-MRVLHLDYNSLREVNSGSLY 271

  Fly   222 GLKSLAFLDLSQNGIKEL-PGAGGIRVFDGLDALTALNLERNLIQSIGETAFAGVRKTLSSLSLL 285
            ||:||..|.|:.|.|... |...|.     .:.|..|||..|.:..:.|.:||.: ..|.||.|.
Zfish   272 GLESLLQLYLANNSISNFNPEGWGF-----CERLRELNLSYNNLTKLSEGSFAKL-VNLISLRLG 330

  Fly   286 NNLLAEFPIGAVHSLKELRVLDIGFNLLTSLPE---AAFRGNPGITLLALDGNPLSSVPEGAFAH 347
            :|.::....||...|..||.|::..|.::...|   .||.|...:..|.|.||.:.||.:.||:.
Zfish   331 HNSISHITEGAFRGLSSLRTLELDHNDISGTIEDTSGAFTGLENLNKLTLFGNKIKSVAKKAFSG 395

  Fly   348 LNATLRGLSLGG-----------------RFLH-------CDCKLRWVAEWIRNGDLQVTSRERN 388
            |.| |..|:||.                 |:||       |||:|.|..:|:       .:|..|
Zfish   396 LEA-LEHLNLGENAIRSIQPEAFSKMKNLRYLHIQSDSFLCDCQLHWFPDWL-------LTRGLN 452

  Fly   389 P---QFCGTPPRFRDRGFYSIQPEELSCPDIADAALRGPVGLADNLKPTLPSSPDSVEYETGTGT 450
            |   ..|..|...:....|...|:...|.|:.              ||.:...|
Zfish   453 PGVQATCAHPESLKGTSIYQAPPQSFVCDDLP--------------KPQITVHP----------- 492

  Fly   451 GTVGTGTAASAPVTSSVSSSTSTTTPTTTTTTTTAEPTTRRST----TRPPTKSTTTISATTASP 511
              |.|.......|..:.::::|:::|.|.|.....| |.|::.    ..........:..||...
Zfish   493 --VTTAAVLGKDVRLTCTAASSSSSPMTFTWLKDQE-TLRQAEVENFAHVRASDGGVMEYTTILH 554

  Fly   512 ASNPPVNGTGTVQATSITTSSSSSSSSSTSTGHGNGKQAPGW---RQGVTNGNGNSG--VGGAGG 571
            ..:...|..|..|........||.|:.:..|.:    ..|.:   .:.:|...|...  ...|.|
Zfish   555 LRHVTFNHEGRYQCIISNHFGSSYSNKARVTVN----VLPSFVKTPRDITIRTGTKARLECAAEG 615

  Fly   572 LHKPQRPPLVLGYPPQRGTRIDDANEVQVKHAFRQDSSVIIQWD-------------SDTANILG 623
            ...||     :.:....||....|.|.:::  ...|..|....|             .:||.::.
Zfish   616 HPTPQ-----VAWQKDGGTDFPAARERRMR--VMPDDDVFFIMDVKPEDMGVYSCTAKNTAGMIS 673

  Fly   624 FRVVYRLF----------------GE------KAFKQGP----------PLESSEREFKIKNVPA 656
            ..|...:.                ||      ||....|          ||.:|:|.   ...|.
Zfish   674 ANVTLTVLETPHLAQEMEDRNVVVGETVALQCKALGSPPPRITWLKGEEPLRASDRH---HFTPG 735

  Fly   657 QECIIV------------CVIS----LEELHVTPETVPYQQCREVRTVASQAS-NMDKITIAASA 704
            .:.:::            ||:|    .|..|  .:...||:..|.....|.:: .:..|.||...
Zfish   736 NQLLVIGSSTLEDAGRYTCVMSNTLGTERAH--SQLTVYQRFEECAPFTSPSTVTVGIIIIAVVT 798

  Fly   705 AICGTIIVAVIVFIAASRRSRKLQSSQQKSPLPIGGLPVNCCGPTGSPGPLGSIATLSAFNNHKE 769
            :|..|.:|.|.:.....::|.:...:..::.:           |...|..|.|..|||      |
Zfish   799 SIVVTSLVWVCIIYQTRKKSEECSVNTDETIV-----------PPDVPSYLSSQGTLS------E 846

  Fly   770 WDQVS---AYSGRSIPRPRI------YPVEQPDDMRSHFSGMPGKVGKSRSLADGQSQHSFSNNS 825
            ...|.   ..:|.|.|..||      .||...|.:                      ::|.|.:.
Zfish   847 RQDVCIRVESNGGSQPNGRIESNGYDVPVVCADCL----------------------ENSTSYSK 889

  Fly   826 HRGYLGSAFPSNLV-NSRPELRQSRQSLAAASERMSRASYAGSIHGGNGGGGGL----------- 878
            |..||    |.:|. .|..|.:|:.|:....|  :|...:.      ||...||
Zfish   890 HCNYL----PHDLAPPSGMEYQQTHQTSTFTS--LSNEPHC------NGTPNGLRKDNQTPIFPT 942

  Fly   879 ---------GGNGGGGGNGLPVSSLMAMSGMVGGGGPASIASSARRSRPRSRSRE------QLNT 928
                     ..|.....|||.|:.         ...|.|:..|..  ||.....|      :|..
Zfish   943 NHDRVTISPSSNQYSDRNGLLVNK---------SDTPLSLEESYH--RPVKLLSEDCDIGSELTQ 996

  Fly   929 THI---HNHRPGSRYSQAGS 945
            |.:   |.|.|.|..:|:.|
Zfish   997 TLLPNGHTHAPSSALNQSQS 1016

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
haf	NP_001356954.1	LRR	<52..>252	CDD:227223	71/240 (30%)
		leucine-rich repeat	86..105	CDD:275380	6/19 (32%)
		leucine-rich repeat	106..129	CDD:275380	9/22 (41%)
		LRR_8	131..189	CDD:338972	25/57 (44%)
		leucine-rich repeat	131..154	CDD:275380	9/22 (41%)
		leucine-rich repeat	155..178	CDD:275380	10/22 (45%)
		leucine-rich repeat	179..202	CDD:275380	11/23 (48%)
		leucine-rich repeat	203..225	CDD:275380	7/22 (32%)
		leucine-rich repeat	226..253	CDD:275380	7/27 (26%)
		LRR_8	254..337	CDD:338972	28/85 (33%)
		leucine-rich repeat	254..302	CDD:275380	16/47 (34%)
		leucine-rich repeat	303..326	CDD:275380	8/25 (32%)
		leucine-rich repeat	327..350	CDD:275380	9/22 (41%)
		PCC	332..>413	CDD:188093	29/107 (27%)
		PRK10927	<1061..>1097	CDD:236797
lrig1	XP_688817.4	LRRNT	31..63	CDD:214470	8/32 (25%)
		leucine-rich repeat	63..84	CDD:275380	2/20 (10%)
		LRR_RI	77..334	CDD:238064	82/264 (31%)
		LRR_8	83..142	CDD:290566	9/58 (16%)
		leucine-rich repeat	85..107	CDD:275380	3/21 (14%)
		leucine-rich repeat	108..131	CDD:275380	3/22 (14%)
		LRR_8	132..191	CDD:290566	20/58 (34%)
		leucine-rich repeat	132..155	CDD:275380	6/22 (27%)
		leucine-rich repeat	156..180	CDD:275380	9/23 (39%)
		leucine-rich repeat	181..203	CDD:275380	9/22 (41%)
		LRR_8	202..262	CDD:290566	24/60 (40%)
		leucine-rich repeat	204..227	CDD:275380	10/22 (45%)
		leucine-rich repeat	228..251	CDD:275380	11/22 (50%)
		LRR_8	251..310	CDD:290566	20/64 (31%)
		leucine-rich repeat	252..275	CDD:275380	7/22 (32%)
		leucine-rich repeat	276..299	CDD:275380	7/27 (26%)
		LRR_8	299..358	CDD:290566	20/59 (34%)
		leucine-rich repeat	300..323	CDD:275380	8/23 (35%)
		leucine-rich repeat	324..347	CDD:275380	8/22 (36%)
		leucine-rich repeat	348..372	CDD:275380	7/23 (30%)
		LRR_4	373..414	CDD:289563	14/41 (34%)
		LRR_8	374..433	CDD:290566	17/59 (29%)
		leucine-rich repeat	375..398	CDD:275380	9/22 (41%)
		leucine-rich repeat	399..420	CDD:275380	4/20 (20%)
		LRRCT	433..481	CDD:214507	13/54 (24%)
		Ig_3	485..572	CDD:290638	18/100 (18%)
		IG_like	492..586	CDD:214653	19/107 (18%)
		I-set	590..680	CDD:254352	17/96 (18%)
		Ig_1	607..681	CDD:143240	14/80 (18%)
		I-set	684..771	CDD:254352	15/91 (16%)
		IGc2	698..761	CDD:197706	13/65 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910