DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment haf and vasna

DIOPT Version :9

Sequence 1:	NP_001356954.1	Gene:	haf / 33339	FlyBaseID:	FBgn0261509	Length:	1347	Species:	Drosophila melanogaster
Sequence 2:	NP_001313614.1	Gene:	vasna / 553185	ZFINID:	ZDB-GENE-050522-43	Length:	688	Species:	Danio rerio

Alignment Length:	838	Identity:	180/838 - (21%)
Similarity:	274/838 - (32%)	Gaps:	295/838 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRPGRTTTALPAATTPL--LLLLPLILGRLHVAHAQCPWQRDVPDLQTSCICAYN---------- 53
            |||          .:||  |:||.|:.|.|   .::||         ..|.|..|
Zfish     1 MRP----------LSPLSHLILLQLLCGCL---SSRCP---------HDCTCLPNNNIFCVQRNL 43

  Fly    54 ---------LGRELSVQCDQVDFSQLLAAMNTHARLKPVDLLYVNNSTISELPDAVFSNL-SLHN 108
                     .|::|.|..::::..|    ......|..:::|.::.:::||:||.|||.| ||||
Zfish    44 IYMPRGLPSTGKQLYVFQNKINILQ----QQDFVELGELEMLDLSQNSLSEIPDGVFSPLSSLHN 104

  Fly   109 LQLSSCGIQRIATGAFKGQESVLRNLNLQDNLLADVPVEALKVLGKLNLLDLSKNQLSHIPDDAF 173
                                                             ||||.|.::||..|:|
Zfish   105 -------------------------------------------------LDLSSNYITHISKDSF 120

  Fly   174 VGLTKLSTLKLNDNNV-TLASNAFRGLEQSLKNLNLKGTKQRKVPESIRGLKSLAFLDLSQNGIK 237
            :||..|..|.|..|.: .:...||.||| :|..|.|:|.:...:|  ...|..|..||||.|.|
Zfish   121 IGLVNLERLYLYSNIIQNIHPAAFEGLE-NLLELKLQGNQISVLP--ALQLPRLLHLDLSYNSI- 181

  Fly   238 ELPGAGGIRVFDGLDALTALNLERNLIQSIGETAFAGVRKTLSSLSLLNNLLAEFPIGAVHSLKE 302
                          ..|.|.:|:...::|:   ..||:..|    ||...||.        ||..
Zfish   182 --------------PPLVAQDLQTPHLESL---KIAGLGLT----SLDEELLG--------SLVN 217

  Fly   303 LRVLDIGFNLLTSLPEAAFRGNPGITLLALDGNPLSSV------------------------PEG 343
            |.|||:..|.|..: :...:...|:..|.|.||||.|:                        |||
Zfish   218 LHVLDVSQNQLVDI-QPTLKSMGGLRNLNLTGNPLGSLKHEDFQNLVNLLELDLSNLNLQGFPEG 281

  Fly   344 AFAHLNATLRGLSLGGRFLHCDCKLRWVAEWIRNGDLQVTSRERNPQFCGTPPRFRDRGFYSIQP 408
             |.:|...|..|:......:|.|.|.|...|::  |::|.........|..||....:....::.
Zfish   282 -FFNLFPKLEKLTAAENPFNCLCPLAWFPAWLK--DVRVELLRTEETRCHFPPINSGKVLEKLEH 343

  Fly   409 EELSCPDIADAALRGPVGLADNLKPTLPSSPDSVEYETGTGTGTVGTGTAASAPVTSSVSSSTST 473
            ::..||...       :.|......:..|.|.:...:.||      |.....|| .|.:||:.:.
Zfish   344 KDFGCPTTT-------IELTSAGTSSTTSKPKNSSTQLGT------THIVPPAP-PSDISSADAD 394

  Fly   474 TTP---TTTTTTTTAEPTTRRSTTRPPT----------KSTTTI-----------------SATT 508
            ..|   ||...:...|.:.......||.          ||...|                 .|..
Zfish   395 NFPVYQTTAFPSRIMEDSEGEGIMCPPNICLNGGTCIFKSNGVIVCLCPPSMSGNYCEIQNEAML 459

  Fly   509 ASPASNPPVNGTGTVQATSITTSSSSSSSSSTSTGHGNGKQAP---GWRQGVTNGNGNSGVGGAG 570
            ..|:....:....|||..:|::...:|:|.|... |...:..|   |.|...:|.:|
Zfish   460 PPPSPRVSLETIATVQPNTISSHHITSTSISLDL-HRYIQTRPHIRGIRLTYSNLSG-------- 515

  Fly   571 GLHKPQRPPLVLGYPPQRGTRIDDANEVQVKHAFRQDSSVIIQWDSDTANILGFRVVYRLFGEKA 635
                |.|.||.|..||
Zfish   516 ----PDRRPLQLSVPP------------------------------------------------- 527

  Fly   636 FKQGPPLESSEREFKIKNVPAQECIIVCVISLEELHVTPETVPYQQCREVRTV----ASQASNMD 696
                     |..|:.::.:.......||...|.|    |.......|.|.||.    :|...::|
Zfish   528 ---------SYPEYTLRGLQPNSTYSVCASPLGE----PVHASVSACMEARTAGIPPSSHEPSVD 579

  Fly   697 KITIAAS-----AAICGTIIVAVIVFIAASRRSRKLQSS-----QQKSPLPIGGLPVN 744
            :...::|     .|:...::||:|..:....|.|:.::.     .:.|||.:.|:..|
Zfish   580 RTEPSSSLTPIVVAVAVVMVVAIIATVVVISRRRRPKAPVDMDLHETSPLEMEGVKTN 637

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
haf	NP_001356954.1	LRR	<52..>252	CDD:227223	52/220 (24%)
		leucine-rich repeat	86..105	CDD:275380	9/19 (47%)
		leucine-rich repeat	106..129	CDD:275380	3/22 (14%)
		LRR_8	131..189	CDD:338972	15/57 (26%)
		leucine-rich repeat	131..154	CDD:275380	0/22 (0%)
		leucine-rich repeat	155..178	CDD:275380	11/22 (50%)
		leucine-rich repeat	179..202	CDD:275380	9/23 (39%)
		leucine-rich repeat	203..225	CDD:275380	6/21 (29%)
		leucine-rich repeat	226..253	CDD:275380	7/26 (27%)
		LRR_8	254..337	CDD:338972	24/82 (29%)
		leucine-rich repeat	254..302	CDD:275380	13/47 (28%)
		leucine-rich repeat	303..326	CDD:275380	6/22 (27%)
		leucine-rich repeat	327..350	CDD:275380	12/46 (26%)
		PCC	332..>413	CDD:188093	23/104 (22%)
		PRK10927	<1061..>1097	CDD:236797
vasna	NP_001313614.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.000