DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment haf and islr2

DIOPT Version :9

Sequence 1:	NP_001356954.1	Gene:	haf / 33339	FlyBaseID:	FBgn0261509	Length:	1347	Species:	Drosophila melanogaster
Sequence 2:	NP_001013541.1	Gene:	islr2 / 541396	ZFINID:	ZDB-GENE-050320-95	Length:	712	Species:	Danio rerio

Alignment Length:	806	Identity:	154/806 - (19%)
Similarity:	257/806 - (31%)	Gaps:	253/806 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   222 GLKSLA-FLDLSQNGIKELPGAGGIRVFDGLDALTALNLERNLIQSIGETAFAGVRKTLSSLSLL 285
            ||.|.| .|.||.|.||.|..    :.|..:..:|:|.|..|.|.::.....|.:.: |.:|.:.
Zfish    50 GLPSNASTLSLSANKIKVLKS----KTFVNVTQVTSLWLAHNEIITVERDTLAPLIQ-LKNLDIS 109

  Fly   286 NNLLAEFPIGAVHSLKELRVLDIGFNLLTSLPEAAFRGNPGITLLALDGNPLSSVPEGAFAHLNA 350
            ||.:..||...:.:|..|::|.:..|.:.|:|:.||.....:..:.::.|..:::.:|.|..| |
Zfish   110 NNKIVHFPWEDLANLGALQLLKMNNNEMVSIPKNAFSNLKDLRSIRINNNKFTTIVQGTFDSL-A 173

  Fly   351 TLRGLSLGGRFLHCDCKLRWVAEWIRNGDLQVTSRERNPQFCGTPPRFRDRGFYSIQPEELSCPD 415
            .:..|.:......|.|.|.|:.:||....:.:.  |:|...|..|...  :|.......:|:|
Zfish   174 AMSHLQIFHNPFICSCNLEWLRDWILKSSISIP--EQNNIACDAPSHL--KGSQVTSMPKLNC-- 232

  Fly   416 IADAALRGPVGLADNLKPTLPSSPDSVEYETGTGTGTVGTGTAASAPVTSSVSSSTSTTT-PTTT 479
                  :.| .::...:|.:..:.....|.......|.||   ....||..:.:.....| |...
Zfish   233 ------KAP-SVSITYQPNIEKTELYEGYMVMLYCETKGT---PKPEVTWEIFAGNQLITFPLPA 287

  Fly   480 TTTTTAEPTTRRSTTRPPTKSTTTI--SATTASPASNPPVNGTGTVQATSITTSSSSS------S 536
            ....:..|     ...|||.:...:  :.|...|..:....|..|..|.:....:.||      .
Zfish   288 IVEKSDIP-----INGPPTNTRFLVFQNGTLIVPRMSKKEEGNYTCSAVNDIGKAESSVRLVVAG 347

  Fly   537 SSSTSTGHGNGKQAPGW----RQGVTNGNGNSGVGGAGGLHKPQRPPLVLGYPPQRGTRIDDANE 597
            :...:|......::||.    :.| :.|:.||.:.     .:|:........|  .||.:...::
Zfish   348 TKKHATNSMLDTKSPGLLPEDKLG-SKGSKNSVIS-----MRPKFEEKTKSLP--TGTSVITVDK 404

  Fly   598 VQV-----------------------KHAFRQDSSVIIQWDSDTANILGFRVVYRLFGEKAFKQG 639
            .||                       .|||......:.|:..|             ||..|
Zfish   405 EQVDEGADTLPFVGKCGINDGTQYISNHAFNLSLDELKQYTFD-------------FGVIA---- 452

  Fly   640 PPLESSEREFKIKNVPAQECIIVCVISLEELHVTPETVPYQQCREVRTVASQASNMDKITIAASA 704
              ||.||.|.|::..|.|     ...:...:|::       |.::::||..:..::
Zfish   453 --LEVSETEAKVQLNPMQ-----MANAKSNIHLS-------QQQDLQTVNKEPFSL--------- 494

  Fly   705 AICGTIIVAVIVFIAASRRSRKLQSSQQKSPLPIGGLPVNCCGPTGSPGPLGSIATLSAFNNHK- 768
                                  .|:|.:||||.:    :..|..||              |.|.
Zfish   495 ----------------------FQTSAKKSPLDL----LYLCVSTG--------------NGHSV 519

  Fly   769 -EWDQ----VSAYSGRSIPRPRIYPVEQPDDMRSHFSGMPGKVGKSRSLA------DGQSQHSFS 822
             :|.:    |:||..:.:                       |.|.:.:|.      |.|.|..|:
Zfish   520 VQWSKIEEGVNAYRFQHL-----------------------KPGTNYTLCLTYGGQDCQVQVVFT 561

  Fly   823 NNSH-------------------------------RGYLGSAFPSNLVNSRPELRQSRQSLAAAS 856
            ....                               ..|.|..:...:....|:  |..:::|...
Zfish   562 TRKKIPSLLIIVVVSIFLLALATVPLLGATCCHLLYKYQGKTYKLIMKTQNPD--QMEKNIATDF 624

  Fly   857 ERMSRASYAGSIHG------GNGGGGGLGGNGGGGGNGLPVSSLMAMSGMVGGGGPASIASSARR 915
            :  .|||:.||...      |.|.|...|..|.|.|..:.                   .|....
Zfish   625 D--PRASFVGSEKNFNPSEMGEGEGEADGEEGDGEGEDIE-------------------GSVVTE 668

  Fly   916 SRPRSRSREQLNTTHIHNHRPGSRYS 941
            |.|.|:|:.|      .....||.||
Zfish   669 SIPESQSKTQ------EEFEVGSEYS 688

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
haf	NP_001356954.1	LRR	<52..>252	CDD:227223	12/30 (40%)
		leucine-rich repeat	86..105	CDD:275380
		leucine-rich repeat	106..129	CDD:275380
		LRR_8	131..189	CDD:338972
		leucine-rich repeat	131..154	CDD:275380
		leucine-rich repeat	155..178	CDD:275380
		leucine-rich repeat	179..202	CDD:275380
		leucine-rich repeat	203..225	CDD:275380	2/2 (100%)
		leucine-rich repeat	226..253	CDD:275380	9/27 (33%)
		LRR_8	254..337	CDD:338972	21/82 (26%)
		leucine-rich repeat	254..302	CDD:275380	13/47 (28%)
		leucine-rich repeat	303..326	CDD:275380	7/22 (32%)
		leucine-rich repeat	327..350	CDD:275380	4/22 (18%)
		PCC	332..>413	CDD:188093	18/80 (23%)
		PRK10927	<1061..>1097	CDD:236797
islr2	NP_001013541.1	leucine-rich repeat	35..53	CDD:275380	2/2 (100%)
		LRR_RI	<47..>184	CDD:238064	38/139 (27%)
		LRR_8	53..113	CDD:290566	20/64 (31%)
		leucine-rich repeat	57..78	CDD:275380	8/24 (33%)
		leucine-rich repeat	79..102	CDD:275380	6/22 (27%)
		LRR_8	102..161	CDD:290566	15/59 (25%)
		leucine-rich repeat	103..126	CDD:275380	7/22 (32%)
		leucine-rich repeat	127..150	CDD:275380	7/22 (32%)
		leucine-rich repeat	151..174	CDD:275380	4/23 (17%)
		LRRCT	183..>221	CDD:214507	10/41 (24%)
		IG_like	252..345	CDD:214653	19/100 (19%)
		Ig	256..345	CDD:299845	18/96 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24366
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100